Reactome | RPTOR [cytosol]

RPTOR [cytosol]

Stable Identifier

R-HSA-3006727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Regulatory-associated protein of mTOR, RPTOR_HUMAN

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Active MTORC1 binds the ULK1 complex (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Active MTORC1 phosphorylates ULK1 (Homo sapiens)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Rheb in the MTORC1 complex hydrolyses GTP (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Cellular responses to external stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Amino acids regulate mTORC1 (Homo sapiens)
    - RRAGA,B hydrolyzes GTP (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1 binds RHEB:GTP (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MAF1 translocates to the nucleus (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
        
        mTORC1 phosphorylates MAF1 (Homo sapiens)
        
        MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
- MTOR signalling (Homo sapiens)
  - AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Formation of active mTORC1 complex (Homo sapiens)
    - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Homo sapiens)
    - mTORC1 [cytosol] (Homo sapiens)
      - RPTOR [cytosol] (Homo sapiens)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
      - mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - mTORC1 phosphorylates AKT1S1 (Homo sapiens)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
  - mTORC1-mediated signalling (Homo sapiens)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
      - Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Homo sapiens)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Homo sapiens)
        
        Active mTORC1 complex [lysosomal membrane] (Homo sapiens)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Homo sapiens)
        
        mTORC1 [cytosol] (Homo sapiens)
        
        RPTOR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N122 RPTOR

Gene Names

RPTOR, KIAA1303, RAPTOR

Chain

chain:1-1335

Reference Genes

BioGPS Gene:57521 RPTOR

COSMIC (genes):RPTOR RPTOR

CTD Gene:57521 RPTOR

dbSNP Gene:57521 RPTOR

ENSEMBL:ENSG00000141564 RPTOR

HGNC:30287 RPTOR

KEGG Gene (Homo sapiens):57521 RPTOR

Monarch:57521 RPTOR

NCBI Gene:57521 RPTOR

OMIM:607130 RPTOR

UCSC:Q8N122 RPTOR

Reference Transcript

Other Identifiers

0002850338

11722496_a_at

11722497_a_at

11722498_s_at

11745456_a_at

11752252_a_at

16838698

225715_at

3737489

3737490

3737491

3737500

3737502

3737519

3737528

3737534

3737539

3737551

3737552

3737553

3737560

3737563

3737565

3737568

3737578

3737581

3737582

3737583

3737584

3737585

3737586

3737593

3737601

3737602

3737604

3737608

3737614

3737615

3737617

3737621

3737623

3737624

3737625

3737626

3737627

3737628

56274_at

57521

8010512

A_14_P113638

A_14_P125470

A_23_P384499

GE53894

GO:0000278

GO:0001030

GO:0001031

GO:0001032

GO:0001156

GO:0001558

GO:0001938

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0006464

GO:0006914

GO:0006950

GO:0007049

GO:0007050

GO:0007165

GO:0008134

GO:0008150

GO:0008283

GO:0008361

GO:0009056

GO:0009058

GO:0009267

GO:0010494

GO:0010506

GO:0010800

GO:0016032

GO:0016241

GO:0019899

GO:0019901

GO:0030234

GO:0030291

GO:0030295

GO:0030307

GO:0030425

GO:0030674

GO:0031669

GO:0031929

GO:0031931

GO:0032008

GO:0032147

GO:0032991

GO:0033138

GO:0034641

GO:0038202

GO:0040007

GO:0042325

GO:0043025

GO:0043226

GO:0044403

GO:0044877

GO:0045945

GO:0071230

GO:0071233

GO:0071889

GO:0071901

GO:0071902

GO:1900034

GO:1900087

Hs.20677.0.S1_3p_at

ILMN_1793514

ILMN_1797816

PH_hs_0023108

TC17000921.hg

Participant Of

hasComponent

mTORC1 [cytosol]

Other forms of this molecule

p-S722,S792-RPTOR [cytosol]

RPTOR [nucleoplasm]

Inferred To

mip1 [cytosol] (Schizosaccharomyces pombe)

rptor [cytosol] (Danio rerio)

rptor [cytosol] (Xenopus tropicalis)

RPTOR [cytosol] (Bos taurus)

RPTOR [cytosol] (Canis familiaris)

RPTOR [cytosol] (Gallus gallus)

RPTOR [cytosol] (Sus scrofa)

raptor [cytosol] (Dictyostelium discoideum)

raptor [cytosol] (Drosophila melanogaster)

KOG1 [cytosol] (Saccharomyces cerevisiae)

Rptor [cytosol] (Mus musculus)

Rptor [cytosol] (Rattus norvegicus)

daf-15 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001156506.1, NP_065812.1

OpenTargets

ENSG00000141564

HPA

ENSG00000141564-RPTOR

GeneCards

Q8N122

Ensembl

ENSP00000460136, ENSP00000442479, ENST00000544334, ENSP00000307272, ENST00000306801, ENST00000570891, ENSG00000141564

PRO

Q8N122

Orphanet

24876

PDB

6BCU, 6SB2, 6U62, 6SB0, 5H64, 6BCX

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13541 EIF4EBP1	2	p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685) EIF4EBP1 [cytosol] (R-HSA-72580)	0.711	5
UniProt:Q96B36 AKT1S1	5	p-S183,T246-AKT1S1 [cytosol] (R-HSA-5672863) AKT1S1 [nucleoplasm] (R-HSA-5083637) p-T246-AKT1S1 [cytosol] (R-HSA-377124) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) AKT1S1 [cytosol] (R-HSA-200155)	0.564	4
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.527	2
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.527	2
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [lysosomal membrane] (R-HSA-5653582)	0.527	2
UniProt:P15056 BRAF	68	p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF [cytosol] (R-HSA-167224) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.527	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.499	3
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.499	6
UniProt:P67999	2	phospho-Rps6kb1 [cytosol] (R-RNO-165714) Rps6kb1 [cytosol] (R-RNO-165716)	0.499	2
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [recycling endosome] (R-HSA-8854761) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131)	0.499	3

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