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Go!
RYK [plasma membrane]
Stable Identifier
R-HSA-3006746
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein kinase RYK ecNumber2.7.10.1/ecNumber, RYK_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
RYK binds WNT5A and VANGL2 (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:RYK:VANGL2 [plasma membrane] (Homo sapiens)
RYK [plasma membrane] (Homo sapiens)
RYK [plasma membrane] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)
RYK [plasma membrane] (Homo sapiens)
RYK:WNTs [plasma membrane] (Homo sapiens)
RYK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34925 RYK
Gene Names
RYK, JTK5A
Chain
signal peptide:1-25, chain:26-607
Reference Genes
BioGPS Gene:6259 RYK
COSMIC (genes):RYK RYK
CTD Gene:6259 RYK
dbSNP Gene:6259 RYK
ENSEMBL:ENSG00000163785 RYK
ENSEMBL_homo_sapiens_GENE:ENSG00000163785.14 RYK
HGNC:10481 RYK
KEGG Gene (Homo sapiens):6259 RYK
Monarch:6259 RYK
NCBI Gene:6259 RYK
OMIM:600524 RYK
Reference Transcript
RefSeq:NM_002958.3 RYK
RefSeq:NM_001005861.2 RYK
Other Identifiers
11740589_s_at
16959412
202853_PM_s_at
202853_s_at
214172_PM_x_at
214172_x_at
216976_PM_s_at
216976_s_at
2696254
2696255
2696256
2696257
2696258
2696261
2696262
2696264
2696267
2696269
2696271
2696272
2696279
2696280
2696281
2696282
2696287
2696292
2696293
2696295
2696296
3706890
3706892
3706895
3706896
3706898
37756_at
539_at
6259
8090840
A_24_P229377
A_33_P3379371
GE58784
GO:0000166
GO:0003824
GO:0004672
GO:0004888
GO:0005109
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005886
GO:0006468
GO:0007165
GO:0007169
GO:0007409
GO:0007411
GO:0007416
GO:0015026
GO:0016020
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0017147
GO:0022008
GO:0022038
GO:0023052
GO:0030154
GO:0030182
GO:0031175
GO:0034330
GO:0035567
GO:0036211
GO:0036518
GO:0042813
GO:0043226
GO:0043235
GO:0043410
GO:0048705
GO:0048843
GO:0048846
GO:0048856
GO:0050919
GO:0060070
GO:0060071
GO:0060089
GO:0071679
GO:0140096
GO:1904935
GO:1904948
HMNXSV003003782
Hs.79350.2.S1_3p_a_at
ILMN_1658526
ILMN_1769671
ILMN_2363439
PH_hs_0040130
S59184_at
TC03003415.hg
g11863158_3p_a_at
g11863158_3p_x_at
Participates
as a component of
RYK:WNTs [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-Wnt5a:RYK:VANGL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:RYK:VANGL2 [plasma membrane] (Homo sapiens)
as an input of
Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)
Wnt5a binds RYK and VANGL2 (Homo sapiens)
RYK binds WNT5A and VANGL2 (Homo sapiens)
Inferred To
RYK [plasma membrane]
(Bos taurus)
RYK [plasma membrane]
(Canis familiaris)
RYK [plasma membrane]
(Drosophila melanogaster)
RYK [plasma membrane]
(Gallus gallus)
RYK [plasma membrane]
(Mus musculus)
RYK [plasma membrane]
(Sus scrofa)
Ryk [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001005861.1
,
NP_002949.2
Guide to Pharmacology - Targets
1849
OpenTargets
ENSG00000163785
HPA
ENSG00000163785-RYK
GeneCards
P34925
Ensembl
ENST00000620660
,
ENSG00000163785
,
ENSP00000485095
,
ENST00000623711
,
ENSP00000478721
PRO
P34925
Pharos - Targets
P34925
HMDB Protein
HMDBP01453
PDB
6TUA
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