Reactome | NGEF [cytosol]

NGEF [cytosol]

Stable Identifier

R-HSA-3006800

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ephexin-1, NGEF_HUMAN

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External Reference Information

External Reference

UniProt:Q8N5V2 NGEF

Gene Names

NGEF

Chain

chain:1-710

Reference Genes

BioGPS Gene:25791 NGEF

COSMIC (genes):NGEF NGEF

CTD Gene:25791 NGEF

dbSNP Gene:25791 NGEF

ENSEMBL:ENSG00000066248 NGEF

HGNC:7807 NGEF

KEGG:hsa:25791 NGEF

Monarch:25791 NGEF

NCBI Gene:25791 NGEF

OMIM:605991 NGEF

UCSC:Q8N5V2 NGEF

Reference Transcript

Other Identifiers

11720569_a_at

11741243_a_at

11752385_a_at

16909608

227240_PM_at

227240_at

243556_PM_at

243556_at

25791

2603988

2603989

2603990

2603991

2603992

2603993

2603994

2603995

2603996

2603997

2603998

2604000

2604001

2604003

2604004

2604008

2604011

2604012

2604013

2604014

2604020

2604024

2604025

2604030

2604031

2604033

2604034

2604037

45561_at

52384_s_at

62570_at

76705_at

8059783

A_23_P102364

A_33_P3240094

GE86970

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0007399

GO:0016020

GO:0030154

GO:0030426

GO:0042995

GO:0043087

GO:0048013

GO:0048856

GO:0051056

GO:0061002

GO:0098772

HMNXSV003026937

HMNXSV003031655

Hs.237517.0.A1_3p_at

Hs.271507.0.S1_3p_at

ILMN_1809613

PH_hs_0012859

RNA147288|p0392_imsncRNA810

TC02002880.hg

Participates

as a member of

as a candidate of

as an input of

NGEF binds EPHA (Homo sapiens)

as a component of

EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y179-NGEF [cytosol]

Inferred To

Exn [cytosol] (Drosophila melanogaster)

NGEF [cytosol] (Bos taurus)

NGEF [cytosol] (Canis familiaris)

NGEF [cytosol] (Gallus gallus)

NGEF [cytosol] (Sus scrofa)

ephx-1 [cytosol] (Caenorhabditis elegans)

ngef [cytosol] (Xenopus tropicalis)

Ephexin-1 [cytosol] (Mus musculus)

Ngef [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001107562.1, NP_062824.2, XP_011509225.1

OpenTargets

ENSG00000066248

ENSEMBL

ENST00000264051, ENST00000409079, ENSP00000387033, ENSP00000264051, ENST00000373552, ENSP00000362653

HPA

ENSG00000066248-NGEF

PRO

Q8N5V2

Pharos - Targets

Q8N5V2

HMDB Protein

HMDBP11508

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	3
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.527	2
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.527	2
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [secretory granule lumen] (R-HSA-6801082)	0.527	2
UniProt:P08631-2 HCK			0.488	2

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