Reactome | RAD17 [nucleoplasm]

RAD17 [nucleoplasm]

Stable Identifier

R-HSA-3008665

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cell cycle checkpoint protein RAD17, RAD17_HUMAN

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        ATR activation at DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        ATR phosphorylates RPA2 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
      - Impaired BRCA2 binding to RAD51 (Homo sapiens)
        
        BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD17:RFC [nucleoplasm] (Homo sapiens)
        
        RAD17 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75943 RAD17

Gene Names

RAD17, R24L

Chain

chain:1-681

Reference Genes

BioGPS Gene:5884 RAD17

COSMIC (genes):RAD17 RAD17

CTD Gene:5884 RAD17

dbSNP Gene:5884 RAD17

ENSEMBL:ENSG00000152942 RAD17

ENSEMBL:ENSG00000152942.19 RAD17

ENSEMBL:ENSG00000276618.4 RAD17

HGNC:9807 RAD17

KEGG Gene (Homo sapiens):5884 RAD17

Monarch:5884 RAD17

NCBI Gene:5884 RAD17

OMIM:603139 RAD17

UCSC:O75943 RAD17

Reference Transcript

Other Identifiers

0003520670

0004280204

0004850132

11720838_a_at

11739778_a_at

11757984_s_at

16985658

207405_PM_s_at

207405_s_at

210826_PM_x_at

210826_x_at

211228_PM_s_at

211228_s_at

2813525

2813526

2813527

2813528

2813529

2813530

2813531

2813532

2813533

2813534

2813535

2813536

2813537

2813538

2813539

2813540

2813541

2813542

2813544

2813545

2813546

2813547

2813548

2813549

2813550

2813551

2813552

2813553

2813554

2813555

2813556

2813560

2813561

2813562

2813563

2813568

3039857

3039859

3039877

32118_at

5884

8105878

8177478

A_23_P159053

A_24_P97836

GE54701

GO:0000076

GO:0000077

GO:0000166

GO:0000278

GO:0000781

GO:0003674

GO:0003682

GO:0003689

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006260

GO:0006281

GO:0006974

GO:0007049

GO:0008150

GO:0008156

GO:0023052

GO:0031389

GO:0031573

GO:0032991

GO:0033314

GO:0042325

GO:0043167

GO:0043226

GO:0140657

HMNXSV003008075

ILMN_1651298

ILMN_1687782

ILMN_1689241

ILMN_1741858

ILMN_1770282

ILMN_2321634

PH_hs_0001493

TC05000302.hg

g3641288_3p_a_at

g4506382_3p_a_at

Participates

as a component of

RAD17:RFC [nucleoplasm] (Homo sapiens)

Inferred To

Rad17 [nucleoplasm] (Drosophila melanogaster)

Rad17 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of RAD17 [nucleoplasm] (Plasmodium falciparum)

rad17 [nucleoplasm] (Xenopus tropicalis)

hpr-17 [nucleoplasm] (Caenorhabditis elegans)

RAD17 [nucleoplasm] (Bos taurus)

RAD17 [nucleoplasm] (Canis familiaris)

RAD17 [nucleoplasm] (Danio rerio)

RAD17 [nucleoplasm] (Dictyostelium discoideum)

RAD17 [nucleoplasm] (Gallus gallus)

RAD17 [nucleoplasm] (Mus musculus)

RAD17 [nucleoplasm] (Saccharomyces cerevisiae)

RAD17 [nucleoplasm] (Schizosaccharomyces pombe)

RAD17 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_579918.1, XP_016865170.1, NP_579919.1, NP_579920.1, NP_579916.1, XP_016865168.1, NP_579921.1, NP_001265551.1, NP_579922.1, NP_579917.1, NP_002864.1, XP_016865169.1

OpenTargets

ENSG00000152942

HPA

ENSG00000152942-RAD17

GeneCards

O75943

Ensembl

ENSP00000303134, ENST00000611523, ENST00000361732, ENSG00000152942, ENSP00000370151, ENST00000282891, ENST00000509734, ENST00000610770, ENSP00000427743, ENST00000354868, ENSP00000478167, ENST00000521422, ENST00000305138, ENSP00000477996, ENSP00000282891, ENST00000616683, ENSP00000479160, ENST00000616488, ENSP00000350725, ENST00000612044, ENSP00000426191, ENSP00000355226, ENSP00000346271, ENSP00000482775, ENST00000358030, ENSP00000482371, ENSG00000276618, ENSP00000484854, ENST00000380774, ENST00000345306, ENST00000620889, ENSP00000477962, ENSP00000311227, ENST00000354312, ENSP00000346938, ENST00000616759

PRO

O75943

Pharos - Targets

O75943

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60934 NBN	3	NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.632	5
UniProt:P49959 MRE11	2	MRE11A [cytosol] (R-HSA-3204309) MRE11A [nucleoplasm] (R-HSA-59544)	0.499	2
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.499	2

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