Reactome | RBPJ [nucleoplasm]

RBPJ [nucleoplasm]

Stable Identifier

R-HSA-3008668

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Recombining binding protein suppressor of hairless, SUH_HUMAN, CBF1

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Regulation of beta-cell development (Homo sapiens)
  - Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
    - NOTCH1 stimulates HES1 transcription (Homo sapiens)
      - NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        NICD1:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
        
        RBPJ [nucleoplasm] (Homo sapiens)
      - NOTCH1 Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
        
        NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        NICD1:RBPJ:SNW1 [nucleoplasm] (Homo sapiens)
        
        RBPJ [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q06330 RBPJ

Gene Names

RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH

Chain

chain:1-500

Reference Genes

BioGPS Gene:3516 RBPJ

COSMIC (genes):RBPJ RBPJ

CTD Gene:3516 RBPJ

dbSNP Gene:3516 RBPJ

ENSEMBL:ENSG00000168214 RBPJ

HGNC:5724 RBPJ

KEGG Gene (Homo sapiens):3516 RBPJ

Monarch:3516 RBPJ

NCBI Gene:3516 RBPJ

OMIM:147183 RBPJ

UCSC:Q06330 RBPJ

Reference Transcript

Other Identifiers

0001170253

0006520025

0006520148

11739392_a_at

11739393_s_at

11757737_s_at

11762366_s_at

16965642

207785_3p_s_at

207785_s_at

211974_3p_x_at

211974_x_at

2722201

2722202

2722204

2722205

2722206

2722207

2722208

2722209

2722210

2722228

2722235

2722237

2722239

2722240

2722241

2722242

2722244

2722245

2722246

2722247

2722248

2722251

2722254

2722255

2722256

2722258

2722260

2722261

2722262

2722263

2722264

2722265

2722266

2F8X

3206395

3516

3NBN

3V79

40818_at

60647

65465_at

8094460

A_23_P29994

A_24_P54797

AAA16253

AAA16254

AAA16356

AAA60258

AAH20780

AAH64976

AC093637

AC097109

AC097714

AC111003

AK302230

BAG63584

BC020780

BC053531

BC064976

CCDS33969

CCDS3436

CCDS3437

CCDS43219

CCDS87214

D6R927

D6R946

D6R9K5

D6R9X3

D6RA45

D6RAT2

D6RB37

D6RBQ8

D6RCM1

D6RE93

D6REC2

D6REP3

D6RF98

D6RIV8

D6RIZ8

ENSG00000168214

ENSP00000305815

ENSP00000339699

ENSP00000340124

ENSP00000345206

ENSP00000347659

ENSP00000354528

ENSP00000423907

ENST00000342295

ENST00000342295.5

ENST00000342320

ENST00000342320.8

ENST00000345843

ENST00000345843.7

ENST00000348160

ENST00000348160.8

ENST00000355476

ENST00000355476.7

ENST00000361572

ENST00000361572.10

ENST00000507561

ENST00000507561.5

EntrezGene:3516

EntrezGene:RBPJ

g7706215_3p_s_at

GE61651

GE62818

GO:0000003

GO:0000122

GO:0000228

GO:0000790

GO:0000978

GO:0000981

GO:0001103

GO:0001228

GO:0001525

GO:0001756

GO:0001837

GO:0001974

GO:0002193

GO:0002376

GO:0002437

GO:0003139

GO:0003151

GO:0003157

GO:0003160

GO:0003176

GO:0003177

GO:0003198

GO:0003214

GO:0003222

GO:0003256

GO:0003674

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0006355

GO:0006357

GO:0006367

GO:0006810

GO:0006950

GO:0006959

GO:0007165

GO:0007219

GO:0007221

GO:0007267

GO:0007507

GO:0008134

GO:0008150

GO:0008283

GO:0008284

GO:0008285

GO:0009058

GO:0009790

GO:0009912

GO:0009957

GO:0010468

GO:0010628

GO:0015031

GO:0017053

GO:0021700

GO:0021983

GO:0030097

GO:0030154

GO:0030182

GO:0030183

GO:0030216

GO:0030279

GO:0030513

GO:0032991

GO:0034641

GO:0035019

GO:0035912

GO:0036302

GO:0040007

GO:0042127

GO:0042592

GO:0042742

GO:0043011

GO:0043226

GO:0043565

GO:0045165

GO:0045596

GO:0045747

GO:0045892

GO:0045944

GO:0047485

GO:0048505

GO:0048646

GO:0048733

GO:0048820

GO:0048844

GO:0048856

GO:0060045

GO:0060412

GO:0060486

GO:0060716

GO:0060844

GO:0061314

GO:0061419

GO:0070491

GO:0072554

GO:0072602

GO:0097101

GO:0120163

GO:1901186

GO:1901189

GO:1901297

GO:2000138

H0Y8R3

HGNC:5724

HPA060647

Hs.278573.0.S1_3p_a_at

Hs.278573.0.S1_3p_s_at

Hs.278573.0.S1_3p_x_at

Hs.278573.1.S1_3p_a_at

ILMN_1680866

ILMN_1708537

ILMN_1726913

ILMN_2316844

IPR008967

IPR013783

IPR014756

IPR015350

IPR015351

IPR036358

IPR037095

IPR038007

IPR040159

L07872

L07874

L07875

L07876

MIM:147183

MIM:614814

NM_001363577

NM_005349

NM_015874

NM_203283

NM_203284

NP_001350506

NP_005340

NP_056958

NP_976028

NP_976029

PF09270

PF09271

PH_hs_0029801

PH_hs_0032754

RBPJ

RBPJ-201

RBPJ-202

RBPJ-203

RBPJ-204

RBPJ-205

RBPJ-206

RBPJ-214

SM01267

SM01268

TC04001945.hg

TC04001946.hg

UPI00001A945C

UPI00001BBFD8

UPI000020BDF1

UPI000020BDF7

UPI0000251DA2

XM_005248161

XM_011513840

XM_017008170

XM_017008171

XM_017008173

XM_017008174

XM_017008175

XM_024454032

XP_005248218

XP_011512142

XP_016863659

XP_016863660

XP_016863662

XP_016863663

XP_016863664

XP_024309800

Participant Of

hasComponent

input

Inferred To

RBPJ [nucleoplasm] (Bos taurus)

RBPJ [nucleoplasm] (Caenorhabditis elegans)

RBPJ [nucleoplasm] (Canis familiaris)

RBPJ [nucleoplasm] (Danio rerio)

RBPJ [nucleoplasm] (Drosophila melanogaster)

RBPJ [nucleoplasm] (Gallus gallus)

RBPJ [nucleoplasm] (Mus musculus)

RBPJ [nucleoplasm] (Rattus norvegicus)

RBPJ [nucleoplasm] (Schizosaccharomyces pombe)

RBPJ [nucleoplasm] (Sus scrofa)

RBPJ [nucleoplasm] (Xenopus tropicalis)

Homologues of RBPJ [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_056958.3, XP_016863662.1, XP_016863664.1, XP_011512142.1, XP_016863663.1, XP_016863661.1, NP_976029.1, NP_005340.2, XP_005248218.1, NP_976028.1

OpenTargets

ENSG00000168214

GeneCards

Q06330

PRO

Q06330

Orphanet

21412

PDB

6PY8, 2F8X, 3V79, 3NBN

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [nucleoplasm] (R-HSA-157939) NICD1 [cytosol] (R-HSA-157634)	0.881	12
UniProt:Q92585 MAML1	1	MAML1 [nucleoplasm] (R-HSA-212416)	0.837	6
UniProt:Q96K30 RITA1			0.729	10
UniProt:P12977 EBNA3			0.646	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.645	5
UniProt:P0C7T5 ATX1L			0.641	7
UniProt:P54253 ATX1			0.641	7
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.641	4
UniProt:Q9Y618 NCOR2	2	SUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.621	3
UniProt:Q01705 Notch1	24	Glc,GlcNAc-Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023154) p-NICD1 [nucleoplasm] (R-MMU-2064842) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-MMU-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-MMU-1911511) Fringe-modified NECD1 [plasma membrane] (R-MMU-2053928) nicd1 [nucleoplasm] (R-MMU-189582) Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-1984030) Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-1985704) Glc,Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023160) Glc,Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-2023167) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-MMU-1472872) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-MMU-1983679) NOTCH1(1665-2555) [Golgi membrane] (R-MMU-157092) NTM [plasma membrane] (R-MMU-206117) NTM' [extracellular region] (R-MMU-206219) Notch1 Extracellular Domain (NECD1) [extracellular region] (R-MMU-2032285) NdeltaE [plasma membrane] (R-MMU-2063913) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-MMU-1911512) NOTCH1(1665-2555) [plasma membrane] (R-MMU-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-MMU-1983670) NICD1 [nucleoplasm] (R-MMU-157939) NEXT1 [plasma membrane] (R-MMU-205889) N1' [plasma membrane] (R-MMU-206107) NICD1 [cytosol] (R-MMU-205738)	0.611	3
UniProt:Q96T58 MINT			0.59	2
UniProt:P0CJ62 RITA1			0.544	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NICD2 [nucleoplasm] (R-HSA-157942) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676)	0.527	2
UniProt:P12978 EBNA2			0.524	2
UniProt:P03204 EBNA6			0.524	3
UniProt:P03203 EBNA4			0.524	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.508	2
UniProt:Q6P3S6 FBX42			0.499	3
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.499	2
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.499	2