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PVRL1 [plasma membrane]
Stable Identifier
R-HSA-3008842
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Poliovirus receptor-related protein 1, PVRL1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00560
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Nectin/Necl trans heterodimerization (Homo sapiens)
Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)
PVRL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15223 NECTIN1
Gene Names
NECTIN1, HVEC, PRR1, PVRL1
Chain
signal peptide:1-30, chain:31-517
Reference Genes
BioGPS Gene:5818 NECTIN1
COSMIC (genes):NECTIN1 NECTIN1
CTD Gene:5818 NECTIN1
dbSNP Gene:5818 NECTIN1
ENSEMBL:ENSG00000110400 NECTIN1
ENSEMBL_homo_sapiens_GENE:ENSG00000110400.11 NECTIN1
HGNC:9706 NECTIN1
KEGG Gene (Homo sapiens):5818 NECTIN1
Monarch:5818 NECTIN1
NCBI Gene:5818 NECTIN1
OMIM:600644 NECTIN1
UCSC:Q15223 NECTIN1
Reference Transcript
RefSeq:NM_002855.4 NECTIN1
RefSeq:NM_203286.1 NECTIN1
RefSeq:NM_203285.1 NECTIN1
Other Identifiers
11718813_a_at
11718814_x_at
11718815_at
11738866_a_at
208455_PM_at
208455_at
211846_PM_s_at
211846_s_at
225211_PM_at
225211_at
3394506
3394507
3394508
3394509
3394510
3394511
3394512
3394513
3394515
3394516
3394518
3394520
3394522
3394523
3394541
3394542
3394543
34999_at
43412_s_at
5818
62287_at
65876_at
7952274
A_23_P76034
A_24_P50890
GO:0001618
GO:0002089
GO:0002376
GO:0002934
GO:0005515
GO:0005576
GO:0005886
GO:0005912
GO:0006826
GO:0006955
GO:0007155
GO:0007156
GO:0007157
GO:0007411
GO:0015026
GO:0016020
GO:0030154
GO:0030246
GO:0030424
GO:0030425
GO:0032584
GO:0034330
GO:0038023
GO:0042734
GO:0042802
GO:0042803
GO:0042995
GO:0043296
GO:0044291
GO:0044877
GO:0045202
GO:0046718
GO:0046790
GO:0048593
GO:0048787
GO:0048856
GO:0050807
GO:0050839
GO:0051963
GO:0060041
GO:0060089
GO:0070166
GO:0098609
GO:0098686
GO:1902414
HMNXSV003047074
Hs.4213.0.A1_3p_at
Hs.4213.0.A1_3p_x_at
ILMN_1695549
ILMN_1720076
ILMN_1744815
PH_hs_0000464
TC11002372.hg
g11602905_3p_at
Participates
as a member of
Nectin [plasma membrane] (Homo sapiens)
as a component of
Necl-1:Nectin-1 trans heterodimer [cell junction] (Homo sapiens)
Nectin-1 cis homodimer [plasma membrane] (Homo sapiens)
as an input of
Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)
Inferred To
NECTIN1 [plasma membrane]
(Bos taurus)
NECTIN1 [plasma membrane]
(Canis familiaris)
NECTIN1 [plasma membrane]
(Sus scrofa)
Nectin1 [plasma membrane]
(Mus musculus)
Nectin1 [plasma membrane]
(Rattus norvegicus)
igcm-3 [plasma membrane]
(Caenorhabditis elegans)
PVRL1 [plasma membrane]
(Gallus gallus)
pvrl1b [plasma membrane]
(Danio rerio)
Fas3 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_976031.1
,
NP_002846.3
,
NP_976030.1
OpenTargets
ENSG00000110400
HPA
ENSG00000110400-NECTIN1
GeneCards
Q15223
Ensembl
ENST00000340882
,
ENSP00000345289
,
ENST00000264025
,
ENSP00000264025
,
ENSG00000110400
PRO
Q15223
Pharos - Targets
Q15223
Orphanet
15174
PDB
3SKU
,
3U82
,
4MYW
,
3ALP
,
4FMF
,
3U83
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15223 NECTIN1
1
PVRL1 [plasma membrane]
(R-HSA-3008842)
0.783
5
UniProt:Q96NY8 NECTIN4
1
PVRL4 [plasma membrane]
(R-HSA-198159)
0.756
6
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.65
8
UniProt:Q9NQS3 NECTIN3
1
PVRL3 [plasma membrane]
(R-HSA-449762)
0.589
3
UniProt:Q9NQS3-1 NECTIN3
0.558
3
UniProt:Q92520 FAM3C
2
FAM3C [extracellular region]
(R-HSA-8848922)
FAM3C [platelet dense granule lumen]
(R-HSA-8848884)
0.556
3
IntAct:EBI-1771356 VGLD
0.524
2
UniProt:Q62083
2
PICK1 [endocytic vesicle membrane]
(R-MMU-417017)
PICK1 [plasma membrane]
(R-MMU-416989)
0.463
2
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