Reactome | PPP2R5C [cytosol]

PPP2R5C [cytosol]

Stable Identifier

R-HSA-3008954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, 2A5G_HUMAN

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Platelet sensitization by LDL (Homo sapiens)
    - PECAM-1 binds PP2A (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - p-PECAM:PP2A [plasma membrane] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-Y307-PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        MAPKs phosphorylate PP2A (Homo sapiens)
        
        PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
        
        PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
        
        PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PP2A dephosphorylates RAF1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        PP2A dephosphorylates KSR1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates inactive RAFs (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Formins (Homo sapiens)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Degradation of beta-catenin by the destruction complex (Homo sapiens)
    - AXIN is phosphorylated in the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Assembly of the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Association of beta-catenin with the destruction complex (Homo sapiens)
      - CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Beta-catenin phosphorylation cascade (Homo sapiens)
      - Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
        
        CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
        
        p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
      - p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
    - Phosphorylation of APC component of the destruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
      - Beta-catenin is released from the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
      - PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13362 PPP2R5C

Gene Names

PPP2R5C, KIAA0044

Chain

chain:1-524

Reference Genes

BioGPS Gene:5527 PPP2R5C

COSMIC (genes):PPP2R5C PPP2R5C

CTD Gene:5527 PPP2R5C

dbSNP Gene:5527 PPP2R5C

ENSEMBL:ENSG00000078304 PPP2R5C

ENSEMBL:ENSG00000078304.20 PPP2R5C

HGNC:9311 PPP2R5C

KEGG Gene (Homo sapiens):5527 PPP2R5C

Monarch:5527 PPP2R5C

NCBI Gene:5527 PPP2R5C

OMIM:601645 PPP2R5C

UCSC:Q13362 PPP2R5C

Reference Transcript

Other Identifiers

11737076_a_at

11737077_x_at

11738876_a_at

11743534_a_at

11743535_s_at

11747241_a_at

1554365_PM_a_at

1554365_a_at

176_at

201877_PM_s_at

201877_s_at

213305_PM_s_at

213305_s_at

2623752

2623757

2623761

3552731

3552733

3552740

3552741

3552749

3552750

3552751

3552777

3552786

3552791

3552792

3552797

3552798

3552799

3552803

3552804

3552807

3552811

3552812

3552813

3552820

3552821

3552825

3552826

3552827

3552828

3552829

3552830

3552848

40784_at

40785_g_at

40786_at

5527

7976863

A_23_P205236

A_24_P369694

GE81184

GO:0000159

GO:0000278

GO:0000775

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005794

GO:0005829

GO:0006470

GO:0006977

GO:0007165

GO:0008285

GO:0012501

GO:0019888

GO:0023052

GO:0030163

GO:0036211

GO:0042771

GO:0043161

GO:0043226

GO:0072542

GO:0098772

HMNXSV003025758

HMNXSV003043150

Hs.171734.2.S1_3p_x_at

ILMN_1780913

ILMN_1795846

PH_hs_0023227

U37352_at

Z69030_s_at

g4506022_3p_a_at

Participates

as a member of

PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)

as a candidate of

PP2A regulatory subunit B56 [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2R5C [nucleoplasm]

p-S337-PPP2R5C [cytosol]

Inferred To

par1 [cytosol] (Schizosaccharomyces pombe)

Homologues of PPP2R5C [cytosol] (Drosophila melanogaster)

Homologues of PPP2R5C [cytosol] (Schizosaccharomyces pombe)

PPP2R5C [cytosol] (Bos taurus)

PPP2R5C [cytosol] (Canis familiaris)

PPP2R5C [cytosol] (Gallus gallus)

PPP2R5C [cytosol] (Sus scrofa)

Ppp2r5c [cytosol] (Mus musculus)

Ppp2r5c [cytosol] (Rattus norvegicus)

pptr-2 [cytosol] (Caenorhabditis elegans)

psrA [cytosol] (Dictyostelium discoideum)

wrd [cytosol] (Drosophila melanogaster)

ppp2r5c [cytosol] (Danio rerio)

ppp2r5c [cytosol] (Xenopus tropicalis)

Dmel\CG32568 [cytosol] (Drosophila melanogaster)

RTS1 [cytosol] (Saccharomyces cerevisiae)

par2 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_848702.1, NP_002710.2, XP_011535222.1, XP_005267884.1, NP_001155198.1, NP_001155197.1, NP_848701.1

OpenTargets

ENSG00000078304

GeneCards

Q13362

HPA

ENSG00000078304-PPP2R5C

Ensembl

ENSP00000412324, ENSP00000262239, ENSG00000078304, ENST00000422945, ENST00000334743, ENSP00000333905, ENST00000445439, ENST00000328724, ENST00000350249, ENSP00000329009, ENSP00000408389

PRO

Q13362

Pharos - Targets

Q13362

PDB

2IAE, 7OUH, 5SW9, 7SOY, 2NYL, 5K6S, 6VOY, 2JAK, 2NPP, 5SWF, 6TOQ, 7OUF, 3FGA, 2NYM, 6OYL, 7PEL, 6VRO, 5JJA, 7OUG

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.65	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.558	5
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.544	2

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