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PPP2R5C [cytosol]
Stable Identifier
R-HSA-3008954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, 2A5G_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by AXIN mutants (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by GSK3beta mutants (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM-1 binds PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-PECAM:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by CTLA4 (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A binds CTLA4 dimer (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 homodimer binds B7-1 homodimer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
CD28 homodimer binds B7-2 monomer (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
MAPKs phosphorylate PP2A (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Association of beta-catenin with the destruction complex (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
Phosphorylation of APC component of the destruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
PPP2R5C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13362 PPP2R5C
Gene Names
PPP2R5C, KIAA0044
Chain
chain:1-524
Reference Genes
COSMIC (genes):PPP2R5C PPP2R5C
dbSNP Gene:5527 PPP2R5C
ENSEMBL:ENSG00000078304 PPP2R5C
Participates
as a member of
PPP2R5B,PPP2R5C [cytosol] (Homo sapiens)
as a candidate of
PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
Other forms of this molecule
PPP2R5C [nucleoplasm]
p-S337-PPP2R5C [cytosol]
Inferred To
par1 [cytosol]
(Schizosaccharomyces pombe)
ppp2r5cb [cytosol]
(Danio rerio)
Homologues of PPP2R5C [cytosol]
(Drosophila melanogaster)
Homologues of PPP2R5C [cytosol]
(Schizosaccharomyces pombe)
PPP2R5C [cytosol]
(Bos taurus)
PPP2R5C [cytosol]
(Canis familiaris)
PPP2R5C [cytosol]
(Gallus gallus)
PPP2R5C [cytosol]
(Sus scrofa)
Ppp2r5c [cytosol]
(Mus musculus)
Ppp2r5c [cytosol]
(Rattus norvegicus)
pptr-2 [cytosol]
(Caenorhabditis elegans)
psrA [cytosol]
(Dictyostelium discoideum)
wrd [cytosol]
(Drosophila melanogaster)
ppp2r5c [cytosol]
(Xenopus tropicalis)
Dmel\CG32568 [cytosol]
(Drosophila melanogaster)
RTS1 [cytosol]
(Saccharomyces cerevisiae)
par2 [cytosol]
(Schizosaccharomyces pombe)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.934
11
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.65
4
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.558
5
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.544
2
UniProt:P51959 CCNG1
1
CCNG1 [nucleoplasm]
(R-HSA-6792489)
0.527
2
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