Reactome | p-Y-SHC3 [cytosol]

p-Y-SHC3 [cytosol]

Stable Identifier

R-HSA-3009043

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-SHC3, SHC-transforming protein 3, SHC3_HUMAN, SHC3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92529 SHC3

Gene Names

SHC3, NSHC, SHCC

Chain

chain:1-594

Reference Genes

BioGPS Gene:53358 SHC3

COSMIC (genes):SHC3 SHC3

CTD Gene:53358 SHC3

dbSNP Gene:53358 SHC3

ENSEMBL:ENSG00000148082 SHC3

ENSEMBL_homo_sapiens_GENE:ENSG00000148082.10 SHC3

HGNC:18181 SHC3

KEGG Gene (Homo sapiens):53358 SHC3

Monarch:53358 SHC3

NCBI Gene:53358 SHC3

OMIM:605263 SHC3

UCSC:Q92529 SHC3

Reference Transcript

RefSeq:NM_016848.5 SHC3

Other Identifiers

11754600_a_at

1511_at

17095566

206330_PM_s_at

206330_s_at

229824_PM_at

229824_at

243881_PM_at

243881_at

3213840

3213842

3213844

3213846

3213848

3213849

3213850

3213859

3213860

3213861

3213864

3213865

3213866

3213873

3213878

3213883

3213884

3213888

3213896

3213897

3213898

53358

62122_at

8162216

85095_at

A_23_P61406

A_24_P484322

A_32_P176036

A_33_P3216090

D84361_at

GE57349

GE806856

GO:0001784

GO:0005515

GO:0005575

GO:0005829

GO:0005886

GO:0007169

GO:0007173

GO:0007417

GO:0023052

GO:0030971

GO:0035556

GO:0048856

HMNXSV003007332

Hs.254119.0.S1_3p_at

Hs.4257.0.A1_3p_at

ILMN_1770905

PH_hs_0009106

TC09001311.hg

TC09002636.hg

TC09002637.hg

g8394263_3p_s_at

Participates

as a member of

p-Y-SHC [cytosol] (Homo sapiens)

Other forms of this molecule

SHC3 [cytosol]

Inferred To

phospho-p-Y-SHC3 [cytosol] (Gallus gallus)

phospho-Shc3 [cytosol] (Mus musculus)

phospho-Shc3 [cytosol] (Rattus norvegicus)

phospho-Shc [cytosol] (Drosophila melanogaster)

phospho-shc3 [cytosol] (Xenopus tropicalis)

phospho-SHC3 [cytosol] (Bos taurus)

phospho-SHC3 [cytosol] (Canis familiaris)

phospho-SHC3 [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_058544.3

OpenTargets

ENSG00000148082

HPA

ENSG00000148082-SHC3

GeneCards

Q92529

Ensembl

ENSP00000364995, ENSG00000148082, ENST00000375835

PRO

Q92529

Pharos - Targets

Q92529

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.675	5
UniProt:Q86U10 ASPG	1	ASPG [cytosol] (R-HSA-6797634)	0.556	3
UniProt:Q96LC9 BMF	3	p-BMF [mitochondrial outer membrane] (R-HSA-3145026) BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3

Cite Us!