Reactome | p-T305,S472-AKT3 [cytosol]

p-T305,S472-AKT3 [cytosol]

Stable Identifier

R-HSA-3009367

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RAC-gamma serine/threonine-protein kinase ecNumber2.7.11.1/ecNumber, AKT3_HUMAN, AKT3

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        PDPK1 phosphorylates AKT at T308 (Homo sapiens)
        
        p-T,p-S-AKT [cytosol] (Homo sapiens)
        
        p-T305,S472-AKT3 [cytosol] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        AKT phosphorylates BAD (Homo sapiens)
        
        p-T,p-S-AKT [cytosol] (Homo sapiens)
        
        p-T305,S472-AKT3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y243 AKT3

Gene Names

AKT3, PKBG

Chain

initiator methionine:, chain:2-479

Reference Genes

BioGPS Gene:10000 AKT3

COSMIC (genes):AKT3 AKT3

CTD Gene:10000 AKT3

dbSNP Gene:10000 AKT3

ENSEMBL:ENSG00000117020 AKT3

ENSEMBL_homo_sapiens_GENE:ENSG00000117020.19 AKT3

ENSEMBL_homo_sapiens_GENE:ENSG00000275199.4 AKT3

HGNC:393 AKT3

KEGG Gene (Homo sapiens):10000 AKT3

Monarch:10000 AKT3

NCBI Gene:10000 AKT3

OMIM:611223 AKT3

UCSC:Q9Y243 AKT3

Reference Transcript

Other Identifiers

10000

11739189_at

11739190_a_at

11739191_at

11758336_s_at

11759289_at

11759290_at

16701238

212607_PM_at

212607_at

212609_PM_s_at

212609_s_at

219393_PM_s_at

219393_s_at

222880_PM_at

222880_at

224229_PM_s_at

224229_s_at

2464006

2464007

2464008

2464009

2464010

2464011

2464012

2464013

2464014

2464020

2464026

2464033

2464035

2464036

2464052

2464053

2464059

2464063

2464068

2464077

2464112

2464113

2464114

2464116

2464118

2464120

40781_at

7925531

87279_at

A_23_P160354

A_24_P110983

A_24_P45481

GE537571

GE56492

GE88420

GO:0000002

GO:0000166

GO:0001938

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0006468

GO:0007005

GO:0007165

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0032008

GO:0035556

GO:0036211

GO:0043226

GO:0043536

GO:0045766

GO:0045793

GO:0048854

GO:0048856

GO:0048870

GO:0048873

GO:0090050

GO:0106310

GO:0140096

GO:1905564

GO:1905653

GO:2000773

HMNXSV003005098

HMNXSV003016224

HMNXSV003022774

Hs.300642.0.S1_3p_at

Hs.300642.0.S1_3p_s_at

Hs.300642.0.S2_3p_at

ILMN_1733598

ILMN_1757130

ILMN_2325610

ILMN_2325612

PH_hs_0023601

TC01004040.hg

TC01006240.hg

U79271_at

g4574743_3p_at

g4885548_3p_a_at

g5912042_3p_a_at

Participates

as a candidate of

p-T,p-S-AKT [cytosol] (Homo sapiens)

Other forms of this molecule

p-T305-AKT3 [cytosol]

AKT3 [cytosol]

AKT3 [plasma membrane]

p-S472-AKT3 [plasma membrane]

p-T305,S472-AKT3 [nucleoplasm]

Inferred To

Homologues of p-T305,S472-AKT3 [cytosol] (Dictyostelium discoideum)

Homologues of p-T305,S472-AKT3 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-T305,S472-AKT3 [cytosol] (Schizosaccharomyces pombe)

Phospho-Akt3 [cytosol] (Rattus norvegicus)

phospho-p-T305,S472-AKT3 [cytosol] (Caenorhabditis elegans)

phospho-p-T305,S472-AKT3 [cytosol] (Danio rerio)

phospho-p-T305,S472-AKT3 [cytosol] (Dictyostelium discoideum)

phospho-p-T305,S472-AKT3 [cytosol] (Drosophila melanogaster)

phospho-p-T305,S472-AKT3 [cytosol] (Mus musculus)

phospho-p-T305,S472-AKT3 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T305,S472-AKT3 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 305

Coordinate

305

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 472

Coordinate

472

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005456.1, NP_001193658.1, NP_859029.1, XP_005273051.1, XP_005273052.1

ZINC - World Drugs

AKT3_HUMAN

Guide to Pharmacology - Targets

2286

OpenTargets

ENSG00000117020

ZINC - FDA approved

AKT3_HUMAN

ZINC - Substances

AKT3_HUMAN

ZINC - Biogenic

AKT3_HUMAN

ZINC target

Q9Y243

PRO

Q9Y243

PDB

2X18

ZINC - Investigational

AKT3_HUMAN

GeneCards

Q9Y243

HPA

ENSG00000117020-AKT3

Ensembl

ENSP00000500582, ENSP00000263826, ENST00000673466, ENSG00000275199, ENSP00000479922, ENST00000336199, ENSP00000336943, ENST00000613395, ENSP00000483054, ENST00000621586, ENST00000619536, ENST00000680118, ENSP00000479081, ENSP00000355498, ENSG00000117020, ENST00000263826, ENSP00000505276, ENST00000366540

Pharos - Targets

Q9Y243

Orphanet

21098

ZINC - Predictions - Purchasable

AKT3_HUMAN

HMDB Protein

HMDBP01363

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.688	5
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.571	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	4
UniProt:P53804 TTC3			0.524	2