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p-SUPT5H [nucleoplasm]
Stable Identifier
R-HSA-3009372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription elongation factor SPT5, SPT5H_HUMAN, SUPT5H
Locations in the PathwayBrowser for interactor UniProt:Q53EZ4 CEP55
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
Formation of DSIF complex (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
mRNA Capping (Homo sapiens)
Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
p-SUPT5H [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00267 SUPT5H
Gene Names
SUPT5H, SPT5, SPT5H
Chain
chain:1-1087
Reference Genes
BioGPS Gene:6829 SUPT5H
COSMIC (genes):SUPT5H SUPT5H
CTD Gene:6829 SUPT5H
dbSNP Gene:6829 SUPT5H
ENSEMBL:ENSG00000196235 SUPT5H
HGNC:11469 SUPT5H
KEGG Gene (Homo sapiens):6829 SUPT5H
Monarch:6829 SUPT5H
NCBI Gene:6829 SUPT5H
OMIM:602102 SUPT5H
UCSC:O00267 SUPT5H
Reference Transcript
RefSeq:NM_001130825.1 SUPT5H
RefSeq:NM_001111020.2 SUPT5H
RefSeq:NM_001319991.1 SUPT5H
RefSeq:NM_001130824.1 SUPT5H
RefSeq:NM_001319990.1 SUPT5H
RefSeq:NM_003169.3 SUPT5H
Other Identifiers
0003450286
11729212_a_at
16862029
16862033
201480_s_at
29273
2DO3
2E6Z
2E70
34370
35826_at
3833043
3833044
3833045
3833046
3833047
3833049
3833050
3833051
3833052
3833056
3833057
3833058
3833059
3833060
3833064
3833065
3833066
3833069
3833070
3833071
3833073
3833074
3833075
3833076
3833078
3833079
3833080
3833082
3833083
3833084
3833085
3833086
3833089
3833090
3833091
3833092
3H7H
4L1U
5OHO
5OHQ
5OIK
5U98
6829
6EQY
6ER0
6GMH
6GML
74385_s_at
8028674
A_23_P27840
A_33_P3364776
AAC51102
AAD02179
AAH24203
AB000516
AB209257
AF040253
BAA24075
BAD92494
BC024203
CAA73326
CAB034370
CCDS12536
CCDS46072
ENSG00000196235
ENSP00000352117
ENSP00000384505
ENSP00000404029
ENSP00000469090
ENSP00000470252
ENST00000359191
ENST00000359191.10
ENST00000402194
ENST00000402194.6
ENST00000432763
ENST00000432763.6
ENST00000598725
ENST00000598725.5
ENST00000599117
ENST00000599117.5
EntrezGene:6829
EntrezGene:SUPT5H
g4507312_3p_a_at
GE61168
GO:0000122
GO:0003674
GO:0003682
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0006366
GO:0006368
GO:0006370
GO:0006397
GO:0006914
GO:0008150
GO:0009056
GO:0009058
GO:0016239
GO:0019899
GO:0032044
GO:0032784
GO:0032785
GO:0032786
GO:0032991
GO:0034641
GO:0043226
GO:0044403
GO:0045944
GO:0046982
GO:0050434
GO:1900364
HGNC:11469
HPA029273
ILMN_1703866
IPR005100
IPR005824
IPR006645
IPR008991
IPR014722
IPR017071
IPR022581
IPR024945
IPR036735
IPR039385
IPR039659
IPR041973
IPR041975
IPR041976
IPR041977
IPR041978
IPR041980
M0QYL9
M0R105
M0R2M5
MIM:602102
NM_001111020
NM_001130824
NM_001130825
NM_001319990
NM_001319991
NM_003169
NP_001104490
NP_001124296
NP_001124297
NP_001306919
NP_001306920
NP_003160
PF00467
PF03439
PF11942
PH_hs_0020631
PH_hs_0033403
SM00738
SM00739
SM01104
SUPT5H
SUPT5H-201
SUPT5H-203
SUPT5H-204
SUPT5H-213
SUPT5H-215
TC19000547.hg
U56402
U56402_s_at
UPI000006D81A
UPI0000202334
XM_017027174
XP_016882663
Y12790
Participant Of
hasComponent
CE:Pol II CTD:Spt5 complex [nucleoplasm]
CE:Pol II CTD:Spt5 complex [nucleoplasm]
DSIF complex [nucleoplasm]
phospho-DSIF complex [nucleoplasm]
input
Formation of DSIF complex
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
output
Methylation of GMP-cap by RNA Methyltransferase
Inferred To
Ghost homologue of p-SUPT5H [nucleoplasm] (Gallus gallus)
phospho-p-SUPT5H [nucleoplasm] (Bos taurus)
phospho-p-SUPT5H [nucleoplasm] (Caenorhabditis elegans)
phospho-p-SUPT5H [nucleoplasm] (Canis familiaris)
phospho-p-SUPT5H [nucleoplasm] (Danio rerio)
phospho-p-SUPT5H [nucleoplasm] (Dictyostelium discoideum)
phospho-p-SUPT5H [nucleoplasm] (Drosophila melanogaster)
phospho-p-SUPT5H [nucleoplasm] (Mus musculus)
phospho-p-SUPT5H [nucleoplasm] (Plasmodium falciparum)
phospho-p-SUPT5H [nucleoplasm] (Rattus norvegicus)
phospho-p-SUPT5H [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-SUPT5H [nucleoplasm] (Schizosaccharomyces pombe)
phospho-p-SUPT5H [nucleoplasm] (Sus scrofa)
phospho-p-SUPT5H [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001124297.1
,
NP_001306920.1
,
NP_001124296.1
,
NP_001104490.1
,
NP_003160.2
,
NP_001306919.1
OpenTargets
ENSG00000196235
GeneCards
O00267
PRO
O00267
Orphanet
24958
PDB
6GMH
,
2E6Z
,
6EQY
,
2DO3
,
5U98
,
5OIK
,
2E70
,
4L1U
,
6ER0
,
3H7H
,
5OHQ
,
6GML
,
5OHO
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63272 SUPT4H1
1
SUPT4H1 [nucleoplasm]
(R-HSA-64905)
0.919
11
UniProt:P24928 POLR2A
7
p-S5,S7-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7-POLR2A [nucleoplasm]
(R-HSA-6814543)
Ub,p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-6781855)
POLR2A [nucleoplasm]
(R-HSA-63502)
p-S5-POLR2A [nucleoplasm]
(R-HSA-77100)
p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-113420)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
0.788
5
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.621
3
UniProt:A5PJW8
1
POLR2B [nucleoplasm]
(R-BTA-63504)
0.582
7
UniProt:P19387 POLR2C
1
POLR2C [nucleoplasm]
(R-HSA-63506)
0.527
2
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.527
2
UniProt:Q9NZN9 AIPL1
0.508
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:P62937 PPIA
5
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.508
2
UniProt:Q53EZ4 CEP55
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.488
2
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
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