SUMO is conjugated to E1 (UBA2:SAE1)

Stable Identifier
R-HSA-3065676
Type
Pathway
Species
Homo sapiens
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The UBA2:SAE1 complex catalyzes the formation of a thioester linkage between the C-terminal glycine of the mature SUMO and a cysteine residue (cysteine-173) in UBA2 (SAE2) (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). During the process the C-terminal glycine residue of SUMO is reacted with ATP to yield pyrophosphate and a transient intermediate, SUMO adenylate. The SUMO adenylate then reacts with the thiol group of the cysteine residue of UBA2 (Olsen et al. 2010).

Literature References
PubMed ID Title Journal Year
19923268 SUMOylation and deSUMOylation at a glance

Wang, Y, Dasso, M

J. Cell. Sci. 2009
20674646 Post-translational modification by SUMO

Hannoun, Z, Greenhough, S, Jaffray, E, Hay, RT, Hay, DC

Toxicology 2010
20164921 Active site remodelling accompanies thioester bond formation in the SUMO E1

Olsen, SK, Capili, AD, Lu, X, Tan, DS, Lima, CD

Nature 2010
21102611 The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

Gareau, JR, Lima, CD

Nat. Rev. Mol. Cell Biol. 2010
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