SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Stable Identifier
R-HSA-3065678
Type
Pathway
Species
Homo sapiens
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SUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). UBC9 is the only known E2 enzyme for SUMO and on certain substrates such as RanGAP1 may act without the requirement of an E3 ligase.

Literature References
PubMed ID Title Journal Year
19923268 SUMOylation and deSUMOylation at a glance

Wang, Y, Dasso, M

J. Cell. Sci. 2009
20674646 Post-translational modification by SUMO

Hannoun, Z, Greenhough, S, Jaffray, E, Hay, RT, Hay, DC

Toxicology 2010
20462400 Mechanisms, regulation and consequences of protein SUMOylation

Wilkinson, KA, Henley, JM

Biochem. J. 2010
21102611 The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

Gareau, JR, Lima, CD

Nat. Rev. Mol. Cell Biol. 2010
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