SUMO is proteolytically processed

Stable Identifier
R-HSA-3065679
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endoproteases that process the precursors to produce the mature peptides (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). SENP1 processes SUMO1 with greater efficiency than SUMO2 or SUMO3. SENP2 and SENP5 process SUMO2 with greater efficiency than SUMO1 or SUMO3 (Gong and Yeh 2006, Mikolajczyk et al. 2007). SENP1 shuttles between the cytosol and nuceoplasm and is predominantly nuclear (Bailey and O'hare 2004, Kim et al. 2005). SENP2 also shuttles (Itahana et al. 2006) and is mainly located on nucleoplasmic filaments of the nuclear pore complex (Hang and Dasso 2002, Zhang et al. 2002). SENP5 is located mostly in the nucleolus (Di Bacco et al. 2006, Gong and Yeh 2006).

Literature References
PubMed ID Title Journal Year
14563852 Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1

Bailey, D, O'Hare, P

J. Biol. Chem. 2004
17591783 Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs

Mikolajczyk, J, Drag, M, Békés, M, Cao, JT, Ronai, Z, Salvesen, GS

J. Biol. Chem. 2007
16608850 Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3

Gong, L, Yeh, ET

J. Biol. Chem. 2006
12192048 Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex

Zhang, H, Saitoh, H, Matunis, MJ

Mol. Cell. Biol. 2002
20674646 Post-translational modification by SUMO

Hannoun, Z, Greenhough, S, Jaffray, E, Hay, RT, Hay, DC

Toxicology 2010
16738315 The SUMO-specific protease SENP5 is required for cell division

Di Bacco, A, Ouyang, J, Lee, HY, Catic, A, Ploegh, H, Gill, G

Mol. Cell. Biol. 2006
16253240 Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1

Kim, YH, Sung, KS, Lee, SJ, Kim, YO, Choi, CY, Kim, Y

FEBS Lett. 2005
19923268 SUMOylation and deSUMOylation at a glance

Wang, Y, Dasso, M

J. Cell. Sci. 2009
16738331 Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2

Itahana, Y, Yeh, ET, Zhang, Y

Mol. Cell. Biol. 2006
20462400 Mechanisms, regulation and consequences of protein SUMOylation

Wilkinson, KA, Henley, JM

Biochem. J. 2010
11896061 Association of the human SUMO-1 protease SENP2 with the nuclear pore

Hang, J, Dasso, M

J. Biol. Chem. 2002
21102611 The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

Gareau, JR, Lima, CD

Nat. Rev. Mol. Cell Biol. 2010
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