Reactome | LEMD2 [nuclear envelope]

LEMD2 [nuclear envelope]

Stable Identifier

R-HSA-3067329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

LEM2, LEM domain-containing protein 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NC56 LEMD2

Gene Names

LEMD2

Chain

initiator methionine:1, chain:2-503

Reference Genes

BioGPS Gene:221496 LEMD2

COSMIC (genes):LEMD2 LEMD2

CTD Gene:221496 LEMD2

dbSNP Gene:221496 LEMD2

ENSEMBL:ENSG00000161904 LEMD2

HGNC:21244 LEMD2

KEGG Gene (Homo sapiens):221496 LEMD2

Monarch:221496 LEMD2

NCBI Gene:221496 LEMD2

OMIM:616312 LEMD2

UCSC:Q8NC56 LEMD2

Reference Transcript

Other Identifiers

0002640280

11741576_a_at

11741577_a_at

11743335_s_at

17018309

221496

224980_at

2950848

2950849

2950850

2950851

2950852

2950853

2950854

2950855

2950856

2950860

2950861

2950865

2950867

2950868

2950870

2950872

2950873

2950874

2950875

2950876

2950877

2950878

2950879

2950880

60869_at

65458_at

8125788

A_24_P305960

GE87062

GO:0000785

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005639

GO:0005694

GO:0005737

GO:0005783

GO:0006464

GO:0006998

GO:0007165

GO:0008150

GO:0009058

GO:0016020

GO:0016021

GO:0022008

GO:0030154

GO:0030514

GO:0031965

GO:0034641

GO:0035914

GO:0043226

GO:0043409

GO:0048646

GO:0048856

GO:0051898

GO:0060914

GO:0061024

GO:0071168

GO:1902531

Hs.164919.0.S1_3p_at

Hs.164919.0.S1_3p_x_at

ILMN_1680860

PH_hs_0033512

TC06001593.hg

Participant Of

output

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

input

CHMP7 binds LEMD2

hasComponent

hasCandidate

EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]

Inferred To

Lemd2 [nuclear envelope] (Mus musculus)

Lemd2 [nuclear envelope] (Rattus norvegicus)

MAN1 [nuclear envelope] (Drosophila melanogaster)

lem-2 [nuclear envelope] (Caenorhabditis elegans)

Ghost homologue of LEMD2 [nuclear envelope] (Danio rerio)

Ghost homologue of LEMD2 [nuclear envelope] (Saccharomyces cerevisiae)

Ghost homologue of LEMD2 [nuclear envelope] (Schizosaccharomyces pombe)

Ghost homologue of LEMD2 [nuclear envelope] (Xenopus tropicalis)

LEMD2 [nuclear envelope] (Bos taurus)

LEMD2 [nuclear envelope] (Canis familiaris)

LEMD2 [nuclear envelope] (Dictyostelium discoideum)

LEMD2 [nuclear envelope] (Gallus gallus)

LEMD2 [nuclear envelope] (Sus scrofa)

Cross References

RefSeq

NP_001335638.1, NP_001137416.1, NP_851853.1

OpenTargets

ENSG00000161904

HPA

ENSG00000161904-LEMD2

GeneCards

Q8NC56

Ensembl

ENST00000508327, ENSP00000421704, ENST00000614475, ENSP00000293760, ENST00000293760, ENSG00000161904, ENSP00000478539

PRO

Q8NC56

Orphanet

24014

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.491	2