Reactome | K48polyUb-DDX58 [cytosol]

K48polyUb-DDX58 [cytosol]

Stable Identifier

R-HSA-3080568

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48polyUb-RIG-I

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Literature References

PubMed ID	Title	Journal	Year
17460044	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 Arimoto, K, Fujita, T, Hishiki, T, Shimotohno, K, Takahashi, H, Konishi, H	Proc Natl Acad Sci U S A	2007

External Reference Information

External Reference

UniProt:O95786 RIGI

Gene Names

RIGI, DDX58

Chain

chain:1-925

Reference Genes

BioGPS Gene:23586 RIGI

COSMIC (genes):DDX58 RIGI

CTD Gene:23586 RIGI

dbSNP Gene:23586 RIGI

ENSEMBL:ENSG00000107201 DDX58

HGNC:19102 RIGI

KEGG:hsa:23586 RIGI

Monarch:23586 RIGI

NCBI Gene:23586 RIGI

OMIM:609631 RIGI

UCSC:O95786 RIGI

Reference Transcript

RefSeq:NM_014314.3 RIGI

Participates

as a member of

K48polyUb-DDX58,K48polyUb-IFIH1 [cytosol] (Homo sapiens)

Other forms of this molecule

DDX58 [cytosol]

K63polyUb-DDX58 [cytosol]

PolyUb-DDX58 [cytosol]

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

Guide to Pharmacology - Targets

2920

ENSEMBL

ENST00000379868, ENST00000379883, ENSP00000369213, ENSP00000369197, ENSG00000107201

OpenTargets

ENSG00000107201

GeneCards

RIGI

HPA

ENSG00000107201-RIGI

PRO

O95786

Pharos - Targets

O95786

Orphanet

RIGI

GlyGen

O95786

HMDB Protein

HMDBP11688

PDB

8SD0, 8G7T, 7TNX, 8G7V, 7TO1, 8G7U, 3LRN, 7JL1, 5F9F, 7BAI, 4ON9, 7JL3, 4AY2, 3OG8, 7TO0, 7MK1, 2RMJ, 2QFB, 2QFD, 2LWD, 4P4H, 5E3H, 8DVU, 7BAH, 3LRR, 3ZD6, 8SCZ, 7TNZ, 3NCU, 4BPB, 8DVS, 2LWE, 6GPG, 4NQK, 2YKG, 3ZD7, 7TNY, 8DVR, 6KYV, 5F98, 7TO2, 5F9H

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.956	19
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.845	9
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.786	15
UniProt:P0DTD1-PRO_0000449623 REP			0.72	6
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.688	5
UniProt:O95786 RIGI	4	DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) PolyUb-DDX58 [cytosol] (R-HSA-6782770)	0.656	3
ChEBI:84491 POLY(I			0.656	3
IntAct:EBI-26608251 NC			0.65	9
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.619	6
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.591	4
UniProt:A0A0B5AC19 NSS			0.59	5
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.589	4
UniProt:Q7Z2W4-2 ZC3HAV1			0.589	4
IntAct:EBI-26977473 3PRNA			0.558	2
UniProt:Q920D5 CASPC			0.557	4
UniProt:Q6UY71 Z			0.544	3
IntAct:EBI-26977583 3’UTR-SENSE			0.544	4
UniProt:Q6IVU5 Z			0.544	3
UniProt:Q6IUF9 Z			0.544	3
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.524	2
UniProt:P04487 RNB			0.524	4
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.524	3
UniProt:Q96S55 WRIP1			0.499	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	3
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2

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