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K63polyUb-PIK3R1 [cytosol]
Stable Identifier
R-HSA-3080572
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-PI3K p85 alpha, K63polyUb-Phosphatidylinositol 3-kinase regulatory alpha subunit, K63polyUb-PI3-kinase p85-alpha subunit, K63polyUb-PtdIns-3-kinase p85-alpha
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
K63polyUb-PI3K alpha [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R1 [cytosol] (Homo sapiens)
K63polyUb-PI3K beta [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R1 [cytosol] (Homo sapiens)
K63polyUb-PI3K delta [cytosol] (Homo sapiens)
K63polyUb-PI3K-regulatory subunits [cytosol] (Homo sapiens)
K63polyUb-PIK3R1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11087752
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells
Fang, D
,
Wang, HY
,
Fang, N
,
Altman, Y
,
Elly, C
,
Liu, YC
J Biol Chem
2001
11526404
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
Fang, D
,
Liu, YC
Nat Immunol
2001
External Reference Information
External Reference
UniProt:P27986 PIK3R1
Gene Names
PIK3R1, GRB1
Chain
initiator methionine:1, chain:2-724
Reference Genes
BioGPS Gene:5295 PIK3R1
COSMIC (genes):PIK3R1 PIK3R1
CTD Gene:5295 PIK3R1
dbSNP Gene:5295 PIK3R1
ENSEMBL:ENSG00000145675 PIK3R1
HGNC:8979 PIK3R1
KEGG Gene (Homo sapiens):5295 PIK3R1
Monarch:5295 PIK3R1
NCBI Gene:5295 PIK3R1
OMIM:171833 PIK3R1
UCSC:P27986 PIK3R1
Reference Transcript
RefSeq:NM_181504.3 PIK3R1
RefSeq:NM_001242466.1 PIK3R1
RefSeq:NM_181524.1 PIK3R1
RefSeq:NM_181523.2 PIK3R1
RefSeq:XM_005248542.3 PIK3R1
RefSeq:XM_017009585.1 PIK3R1
Other Identifiers
0000770592
0001190184
0004610204
0005050156
11733017_a_at
11733018_s_at
11733019_a_at
11739539_a_at
11739540_a_at
11739541_a_at
11748670_a_at
11754631_x_at
1216
1269_at
16985518
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
212239_at
212240_s_at
212249_at
2813091
2813092
2813101
2813102
2813103
2813125
2813127
2813132
2813134
2813135
2813137
2813140
2813142
2813143
2813145
2813146
2813148
2813150
2813152
2813153
2813154
2813155
2813156
2813157
2813158
2813159
2IUG
2IUH
2IUI
2RD0
2V1Y
35373_at
3HHM
3HIZ
3I5R
3I5S
4268
44015_at
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5295
55623_at
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
73148_at
73150_g_at
77475_at
8105778
A0A2X0SFG1
A_14_P105607
A_23_P144980
A_24_P29401
AAB04140
AAH30815
AAH94795
AAO15359
AC016564
AC104120
AF279367
AK094785
AK223613
BAD97333
BAG52931
BC030815
BC094795
CAB004268
CCDS3993
CCDS3994
CCDS3995
CCDS56374
CH471137
E5RGI8
E5RHI0
E5RJY0
E5RK66
EAW51312
EAW51313
ENSG00000145675
ENSP00000323512
ENSP00000338554
ENSP00000428056
ENSP00000429277
ENSP00000430098
ENST00000320694
ENST00000320694.12
ENST00000336483
ENST00000336483.9
ENST00000521381
ENST00000521381.5
ENST00000521657
ENST00000521657.5
ENST00000523872
ENST00000523872.1
EntrezGene:5295
EntrezGene:PIK3R1
GE58013
GE85962
GE88834
GO:0000902
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0003674
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005886
GO:0005911
GO:0005942
GO:0005943
GO:0006464
GO:0006468
GO:0006606
GO:0006629
GO:0006661
GO:0006810
GO:0006913
GO:0006950
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0007173
GO:0007186
GO:0007411
GO:0008134
GO:0008150
GO:0008219
GO:0008286
GO:0008625
GO:0008630
GO:0009058
GO:0014065
GO:0014068
GO:0015031
GO:0016020
GO:0016032
GO:0016192
GO:0019221
GO:0019899
GO:0019903
GO:0022607
GO:0030154
GO:0030168
GO:0030183
GO:0030234
GO:0030335
GO:0030674
GO:0031295
GO:0032760
GO:0032869
GO:0032991
GO:0033120
GO:0034641
GO:0034644
GO:0034976
GO:0035014
GO:0036312
GO:0038095
GO:0038096
GO:0038128
GO:0040011
GO:0042307
GO:0042592
GO:0043066
GO:0043125
GO:0043226
GO:0043548
GO:0043551
GO:0043559
GO:0043560
GO:0044403
GO:0045671
GO:0045944
GO:0046326
GO:0046626
GO:0046854
GO:0046935
GO:0046982
GO:0048009
GO:0048010
GO:0048015
GO:0048856
GO:0048870
GO:0050821
GO:0050852
GO:0050900
GO:0051492
GO:0051897
GO:0055085
GO:0060396
GO:1900103
GO:1903076
GO:1903078
GO:1990578
H0YB27
H0YBC2
HGNC:8979
HPA001216
Hs.6241.0.S1_3p_a_at
Hs.6241.0.S2_3p_at
Hs.6241.0.S3_3p_at
ILMN_1689057
ILMN_1691433
ILMN_1760303
ILMN_2289433
ILMN_2398235
IPR000198
IPR000980
IPR001452
IPR008936
IPR032498
IPR035020
IPR035022
IPR035591
IPR036028
IPR036860
LS482401
M61906
M61906_at
MIM:171833
MIM:269880
MIM:615214
MIM:616005
NM_001242466
NM_181504
NM_181523
NM_181524
NP_001229395
NP_852556
NP_852664
NP_852665
PF00017
PF00620
PF16454
PH_hs_0021977
PIK3R1
PIK3R1-201
PIK3R1-202
PIK3R1-211
PIK3R1-213
PIK3R1-216
PR00401
PR00678
SM00252
SM00324
SM00326
SPT35778
TC05000291.hg
U49349
UPI00000743EC
UPI000013D9FF
UPI000014094F
UPI0000E5AC63
XM_005248542
XM_011543493
XM_017009585
XM_017009586
XP_005248599
XP_011541795
XP_016865074
XP_016865075
Participant Of
hasMember
K63polyUb-PI3K-regulatory subunits [cytosol]
Other forms of this molecule
PIK3R1 G376R [plasma membrane]
PIK3R1 K379E [plasma membrane]
PIK3R1 Y463_L466del [plasma membrane]
PIK3R1 H450_E451del [plasma membrane]
PIK3R1 R574_T576del [plasma membrane]
PIK3R1 D560Y [plasma membrane]
PIK3R1 N564D [plasma membrane]
PIK3R1 K459del [plasma membrane]
PIK3R1 N564K [plasma membrane]
PIK3R1 D560H [plasma membrane]
PIK3R1 R574I [plasma membrane]
PIK3R1 R574T [plasma membrane]
PIK3R1 [cytosol]
PIK3R1 [plasma membrane]
Inferred To
K63polyUb-PIK3R1 [cytosol] (Bos taurus)
K63polyUb-PIK3R1 [cytosol] (Caenorhabditis elegans)
K63polyUb-PIK3R1 [cytosol] (Canis familiaris)
K63polyUb-PIK3R1 [cytosol] (Danio rerio)
K63polyUb-PIK3R1 [cytosol] (Drosophila melanogaster)
K63polyUb-PIK3R1 [cytosol] (Gallus gallus)
K63polyUb-PIK3R1 [cytosol] (Mus musculus)
K63polyUb-PIK3R1 [cytosol] (Rattus norvegicus)
K63polyUb-PIK3R1 [cytosol] (Sus scrofa)
K63polyUb-PIK3R1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_016865074.1
,
NP_852556.2
,
XP_005248599.1
,
NP_852665.1
,
NP_001229395.1
,
NP_852664.1
ZINC - World Drugs
P85A_HUMAN
OpenTargets
ENSG00000145675
ZINC - Substances
P85A_HUMAN
ZINC - Biogenic
P85A_HUMAN
ZINC target
P27986
PRO
P27986
PDB
1AZG
,
2IUG
,
5SXE
,
5UL1
,
5SXD
,
4A55
,
5UKJ
,
2IUH
,
1PBW
,
5SXI
,
2IUI
,
5SXF
,
4WAF
,
5SWO
,
3HIZ
,
5AUL
,
5UBT
,
5XGJ
,
5UK8
,
5SXA
,
4YKN
,
5XGI
,
5SWR
,
4JPS
,
5SXJ
,
5SXK
,
1A0N
,
5VLR
,
4L2Y
,
5SWP
,
4L23
,
5SX8
,
5SWT
,
5SW8
,
1PHT
,
3I5S
,
5SX9
,
5ITD
,
5M6U
,
4OVU
,
5SWG
,
5XGH
,
1H9O
,
6NCT
,
1PIC
,
4L1B
,
2V1Y
,
4ZOP
,
5GJI
,
5FI4
,
4OVV
,
1PKS
,
3I5R
,
5SXB
,
5SXC
,
3HHM
,
2RD0
,
1PKT
ZINC - Metabolites
P85A_HUMAN
GeneCards
P27986
ZINC - Predictions - Purchasable
P85A_HUMAN
Orphanet
22044
HMDB Protein
HMDBP03978
Interactors (70)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42336 PIK3CA
25
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
PIK3CA R38H [cytosol]
(R-HSA-1500718)
PIK3CA R38S [cytosol]
(R-HSA-2395947)
PIK3CA R38G [cytosol]
(R-HSA-2395950)
PIK3CA R38C [cytosol]
(R-HSA-1500691)
PIK3CA [cytosol]
(R-HSA-74787)
0.957
22
UniProt:P09619 PDGFRB
3
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.948
19
UniProt:P22681 CBL
6
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
CBL [cytosol]
(R-HSA-112199)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.94
16
UniProt:P35568 IRS1
5
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
IRS1 [cytosol]
(R-HSA-74769)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
0.921
13
UniProt:P21860 ERBB3
0.921
41
UniProt:P10747 CD28
3
CD28 [plasma membrane]
(R-HSA-167632)
CD28 [cytosol]
(R-HSA-167628)
p-Y191-CD28 [plasma membrane]
(R-HSA-388756)
0.903
10
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.863
6
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.829
6
UniProt:P12931 SRC
6
p-Y416-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.822
7
UniProt:Q13480 GAB1
4
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
GAB1 [cytosol]
(R-HSA-179795)
0.796
33
UniProt:P60953 CDC42
3
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
0.794
10
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.779
6
UniProt:P10721 KIT
4
p-S741,S746-KIT [plasma membrane]
(R-HSA-1433492)
p-8Y-KIT [plasma membrane]
(R-HSA-1472116)
KIT [plasma membrane]
(R-HSA-197662)
p-7Y-KIT [plasma membrane]
(R-HSA-205207)
0.77
19
UniProt:P08069 IGF1R
3
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.752
4
UniProt:O00329 PIK3CD
2
PIK3CD [plasma membrane]
(R-HSA-392274)
PIK3CD [cytosol]
(R-HSA-1806204)
0.744
6
UniProt:P62999 RAC1
0.717
5
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.688
3
UniProt:P04626 ERBB2
12
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.688
11
UniProt:P06213 INSR
6
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.688
3
UniProt:Q9Y4H2 IRS2
4
IRS2 [cytosol]
(R-HSA-57528)
IRS2 [plasma membrane]
(R-HSA-2428927)
p-Y-IRS2 [cytosol]
(R-HSA-74774)
p-Y-IRS2 [plasma membrane]
(R-HSA-198334)
0.688
3
UniProt:P03496 NS
2
NS1 [cytosol]
(R-FLU-169118)
NS1 [nucleoplasm]
(R-FLU-169113)
0.659
6
UniProt:P16410 CTLA4
2
CTLA4 [plasma membrane]
(R-HSA-179764)
p-Y165,Y182-CTLA4 [plasma membrane]
(R-HSA-388754)
0.643
3
UniProt:P30874 SSTR2
1
SSTR2 [plasma membrane]
(R-HSA-374757)
0.639
5
UniProt:Q9Y6W8 ICOS
0.623
5
UniProt:P45983 MAPK8
3
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.623
6
UniProt:P11362 FGFR1
8
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
0.623
5
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.611
3
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.609
2
UniProt:Q99152 VP3
0.591
3
UniProt:P16885 PLCG2
10
p-PLCG2 [plasma membrane]
(R-HSA-114602)
PLCG2 [cytosol]
(R-HSA-984806)
PLCG2 [plasma membrane]
(R-HSA-114601)
p-Y753,Y759,Y1217-PLCG2 [plasma membrane]
(R-HSA-984816)
PLCG2 [plasma membrane]
(R-HSA-2023875)
p-4Y-PLCG2 [plasma membrane]
(R-HSA-2685601)
p-Y753,Y759-PLCG2 [plasma membrane]
(R-HSA-5607640)
p-Y753,Y759-PLCG2 [cytosol]
(R-HSA-5607631)
PLCG2 [cytosol]
(R-HSA-1604645)
p-Y-PLCG2 [cytosol]
(R-HSA-9029105)
0.589
2
UniProt:P49023 PXN
4
PXN [plasma membrane]
(R-HSA-180493)
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.589
2
UniProt:P46109 CRKL
2
p-CRKL [cytosol]
(R-HSA-9024730)
CRKL [cytosol]
(R-HSA-354384)
0.589
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.589
2
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.589
3
UniProt:P62994 Grb2
3
GRB2-1 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-55929)
GRB2-1 [cytosol]
(R-RNO-74686)
0.589
2
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-6Y-SYK [cytosol]
(R-HSA-983586)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
0.581
5
UniProt:P41970 ELK3
0.573
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.564
7
UniProt:O43493 TGOLN2
8
TGOLN2 [plasma membrane]
(R-HSA-8864458)
TGOLN2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869127)
TGOLN2 [Golgi membrane]
(R-HSA-434342)
TGOLN2 [cytoplasmic vesicle membrane]
(R-HSA-429818)
TGOLN2 [trans-Golgi network membrane]
(R-HSA-6811008)
TGOLN2 [transport vesicle]
(R-HSA-6811011)
p-TGOLN2 [endoplasmic reticulum lumen]
(R-HSA-8956886)
TGOLN2 [endoplasmic reticulum lumen]
(R-HSA-8956702)
0.564
2
UniProt:P35570 Irs1
7
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-1168867)
phospho-p-6Y-IRS1 [plasma membrane]
(R-RNO-2445090)
IRS1 [plasma membrane]
(R-RNO-2425392)
IRS1 [cytosol]
(R-RNO-74769)
phospho-p-Y-IRS1 [cytosol]
(R-RNO-74772)
phospho-p-Y-IRS1 [plasma membrane]
(R-RNO-198366)
0.564
2
UniProt:Q9UQC2 GAB2
4
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
GAB2 [cytosol]
(R-HSA-508239)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
0.564
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.564
2
UniProt:Q13111 CAF1A
0.564
2
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.564
2
UniProt:P19793 RXRA
4
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
SUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.556
8
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.553
7
UniProt:Q13746 Q13746
0.544
3
UniProt:Q86VI4-3 LAPTM4B
0.524
2
UniProt:O15455 TLR3
6
TLR3 P554S [endosome membrane]
(R-HSA-5602428)
TLR3 E746* [endosome membrane]
(R-HSA-5602730)
TLR3 [endoplasmic reticulum membrane]
(R-HSA-1679057)
TLR3 [endolysosome membrane]
(R-HSA-167941)
TLR3 [Golgi membrane]
(R-HSA-1678955)
TLR3 [endosome membrane]
(R-HSA-2000341)
0.524
2
UniProt:Q8BM65-4 NYAP2
0.524
3
UniProt:Q8IY22 CMIP
0.524
2
UniProt:P48025 Syk
6
Syk [cytosol]
(R-MMU-442293)
phospho-p-Y-SYK [plasma membrane]
(R-MMU-429432)
p-Y348,Y352,Y525,Y526-Syk [cytosol]
(R-MMU-5621123)
phospho-p-Y348-SYK [cytosol]
(R-MMU-437953)
SYK [cytosol]
(R-MMU-58268)
phospho-p-6Y-SYK [cytosol]
(R-MMU-983586)
0.524
2
UniProt:Q6PFX7 NYAP1
0.524
4
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.488
2
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.463
3
UniProt:P21145 MAL
0.463
3
UniProt:O00329-2 PIK3CD
0.463
2
UniProt:P30875
1
SSTR2 [plasma membrane]
(R-MMU-374757)
0.462
2
UniProt:Q16584 MAP3K11
1
MAP3K11 [cytosol]
(R-HSA-449607)
0.462
3
UniProt:P29350 PTPN6
5
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
0.462
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
2
UniProt:P06127 CD5
0.462
2
UniProt:P45984 MAPK9
3
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
0.462
3
UniProt:P25963 NFKBIA
10
NFKBIA [cytosol]
(R-HSA-168151)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
SUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
0.462
2
UniProt:O43561 LAT
3
LAT [plasma membrane]
(R-HSA-202322)
p-Y200,Y220-LAT [plasma membrane]
(R-HSA-434829)
p-5Y-LAT [plasma membrane]
(R-HSA-202364)
0.462
4
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.462
5
UniProt:P04629 NTRK1
4
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
UniProt:P30530 AXL
2
p-Y772,Y814-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.462
2
UniProt:P32927 CSF2RB
6
CSF2RB [plasma membrane]
(R-HSA-879960)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.462
4
UniProt:O14733 MAP2K7
4
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.462
3
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