Reactome: A Curated Pathway Database

SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

Stable Identifier
R-HSA-3108212
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOylates the RAD21 and STAG2 subunits of cohesin with SUMO1 (Potts et al. 2006 supplementary data, reviewed in Stephan et al 2011). RAD21 (SCC1) is SUMOylated at several lysines (Wu et al. 2012). SUMOylation of RAD21 occurs during DNA damage repair and is necessary for sister chromatid recombination (Wu et al. 2012).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of SMC5-SMC6 Complex [nucleoplasm] SMC5-SMC6 Complex [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events