SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

Stable Identifier
R-HSA-3108212
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOylates the RAD21 and STAG2 subunits of cohesin with SUMO1 (Potts et al. 2006 supplementary data, reviewed in Stephan et al 2011). RAD21 (SCC1) is SUMOylated at several lysines (Wu et al. 2012). SUMOylation of RAD21 occurs during DNA damage repair and is necessary for sister chromatid recombination (Wu et al. 2012).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SMC5-SMC6 Complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events