SUMOylation of DNA damage response and repair proteins

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R-HSA-3108214
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Pathway
Species
Homo sapiens
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Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thymine DNA glycosylase (TDG) causes TDG to lose affinity for its product, an abasic site opposite a G residue, and thus increases turnover of the enzyme. During repair of double-strand breaks SUMO1, SUMO2, SUMO3, and the SUMO E3 ligases PIAS1 and PIAS4 accumulate at double-strand breaks where BRCA1, HERC1, RNF168, MDC1, and TP53BP1 are SUMOylated. SUMOylation of BRCA1 may increase its ubiquitin ligase activity while SUMOylation of MDC1 and HERC2 appears to play a role in recruitment of proteins such as RNF4 and RNF8 to double strand breaks. Similarly SUMOylation of RPA1 (RPA70) recruits RAD51 in the homologous recombination pathway.

Literature References
PubMed ID Title Journal Year
23416108 Regulation of DNA damage responses by ubiquitin and SUMO

Jackson, SP, Durocher, D

Mol. Cell 2013
23122649 Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair

Psakhye, I, Jentsch, S

Cell 2012
23781231 It takes two to tango: Ubiquitin and SUMO in the DNA damage response

Bologna, S, Ferrari, S

Front Genet 2013
21896653 Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair

van Wijk, SJ, Müller, S, Dikic, I

Genes Dev. 2011
22018829 SUMO playing tag with ubiquitin

Praefcke, GJ, Hofmann, K, Dohmen, RJ

Trends Biochem. Sci. 2012
22357966 Ubiquitin and SUMO in DNA repair at a glance

Ulrich, HD

J. Cell. Sci. 2012
21664912 The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

Bekker-Jensen, S, Mailand, N

FEBS Lett. 2011
24926426 Sumoylation and the DNA damage response

Cremona, CA, Sarangi, P, Zhao, X

Biomolecules 2012
21486569 SUMOylation and de-SUMOylation in response to DNA damage

Dou, H, Huang, C, Van Nguyen, T, Lu, LS, Yeh, ET

FEBS Lett. 2011
23746258 Sumoylation: a regulatory protein modification in health and disease

Flotho, A, Melchior, F

Annu. Rev. Biochem. 2013
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