Reactome | SUMO2,3-K428-CTBP1 [nucleoplasm]

SUMO2,3-K428-CTBP1 [nucleoplasm]

Stable Identifier

R-HSA-3108226

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2,3 N-glycyl-lys428 CTBP1, C-terminal-binding protein 1, CTBP1_HUMAN, CtBP

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Locations in the PathwayBrowser for interactor UniProt:O43474

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Literature References

PubMed ID	Title	Journal	Year
20098713	A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity Merrill, JC, Melhuish, TA, Kagey, MH, Yang, SH, Sharrocks, AD, Wotton, D	PLoS ONE	2010
20176810	The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif Yang, SH, Sharrocks, AD	Mol. Cell. Biol.	2010

External Reference Information

External Reference

UniProt:Q13363 CTBP1

Gene Names

CTBP1, CTBP

Chain

chain:1-440

Reference Genes

BioGPS Gene:1487 CTBP1

COSMIC (genes):CTBP1 CTBP1

CTD Gene:1487 CTBP1

dbSNP Gene:1487 CTBP1

ENSEMBL:ENSG00000159692 CTBP1

HGNC:2494 CTBP1

KEGG Gene (Homo sapiens):1487 CTBP1

Monarch:1487 CTBP1

NCBI Gene:1487 CTBP1

OMIM:602618 CTBP1

UCSC:Q13363 CTBP1

Reference Transcript

Other Identifiers

11719960_a_at

11719961_s_at

11738637_a_at

11745679_a_at

1487

203392_s_at

212863_x_at

213980_s_at

2757035

2757037

2757038

2757039

2757040

2757041

2757042

2757043

2757046

2757048

2757051

2757058

2757059

2757071

2757072

2757073

2757080

2757103

2757104

2757112

2757113

41308_at

41309_g_at

43382_s_at

55310_at

8098880

A_23_P41286

A_23_P41292

A_24_P208992

A_33_P3357979

GE61587

GO:0000122

GO:0001226

GO:0003674

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0006342

GO:0006464

GO:0006468

GO:0007049

GO:0008022

GO:0008134

GO:0008150

GO:0008283

GO:0008285

GO:0009058

GO:0016032

GO:0016491

GO:0016616

GO:0017053

GO:0019079

GO:0019904

GO:0030154

GO:0031065

GO:0032991

GO:0034641

GO:0035067

GO:0042802

GO:0043226

GO:0044403

GO:0045892

GO:0050872

GO:0051276

GO:0051287

GO:0051726

GO:0055114

GO:0070491

GO:0090241

HMNXSV003052557

Hs.239737.2.A1_3p_a_at

Hs.239737.2.A1_3p_x_at

ILMN_1719158

ILMN_1782327

ILMN_2278235

ILMN_2379734

TC04000963.hg

U37408_at

g4557496_3p_a_at

Participates

as an output of

PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

SUMO1-K428-CTBP1 [nucleoplasm]

CTBP1 [nucleoplasm]

Inferred To

SUMO2,3-K428-CTBP1 [nucleoplasm] (Danio rerio)

CtBP [nucleoplasm] (Drosophila melanogaster)

Ctbp1 [nucleoplasm] (Mus musculus)

Ctbp1 [nucleoplasm] (Rattus norvegicus)

CTBP1 [nucleoplasm] (Gallus gallus)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 428

Coordinate

428

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001319.1, NP_001012632.1, XP_016863253.1, XP_016863255.1, XP_016863256.1, XP_016863254.1

OpenTargets

ENSG00000159692

HPA

ENSG00000159692-CTBP1

GeneCards

Q13363

Ensembl

ENSP00000372411, ENST00000290921, ENST00000382952, ENSP00000290921, ENSG00000159692

PRO

Q13363

HMDB Protein

HMDBP02216

PDB

6CDF, 1MX3, 4U6Q, 4U6S, 6CDR, 4LCE

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399)	0.691	4
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) SUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) SUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226)	0.668	4
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.667	3
UniProt:Q8N3X6 LCORL			0.659	3
UniProt:Q8N895 ZN366			0.633	5
UniProt:O00257 CBX4	2	CBX4 [nucleoplasm] (R-HSA-389118) SUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626)	0.602	4
UniProt:P03255 E1A			0.593	3
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) SUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.592	2
UniProt:Q14526 HIC1	2	HIC1 [nucleoplasm] (R-HSA-4090364) SUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368)	0.573	2
UniProt:P37275 ZEB1	1	ZEB1 [nucleoplasm] (R-HSA-6789836)	0.564	2
UniProt:O15409 FOXP2			0.553	2
UniProt:Q96JN0-2 LCOR			0.547	2
UniProt:Q69140 EBNA6			0.544	2
UniProt:Q96JN0 LCOR			0.527	2
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015)	0.527	2
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.527	2
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.524	4
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.508	2
UniProt:Q96EK4 THA11			0.508	2
UniProt:Q9BXL5 HEMGN			0.508	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:A2APF7 A2APF7			0.499	2

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