Reactome | p-T38-ETS1 [nucleoplasm]

p-T38-ETS1 [nucleoplasm]

Stable Identifier

R-HSA-3132720

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:P05412 JUN

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External Reference Information

External Reference

UniProt:P14921 ETS1

Gene Names

ETS1, EWSR2

Chain

chain:1-441

Reference Genes

BioGPS Gene:2113 ETS1

COSMIC (genes):ETS1 ETS1

CTD Gene:2113 ETS1

dbSNP Gene:2113 ETS1

ENSEMBL:ENSG00000134954 ETS1

ENSEMBL:ENSG00000134954.14 ETS1

HGNC:3488 ETS1

KEGG Gene (Homo sapiens):2113 ETS1

Monarch:2113 ETS1

NCBI Gene:2113 ETS1

OMIM:164720 ETS1

UCSC:P14921 ETS1

Reference Transcript

Other Identifiers

11722300_a_at

11722301_a_at

11752387_a_at

1518_at

1555355_PM_a_at

1555355_a_at

16745997

1977_s_at

2113

214447_PM_at

214447_at

224833_PM_at

224833_at

3397578

3397580

3397582

3397584

3397586

3397588

3397590

3397591

3397592

3397593

3397594

3397595

3397596

3397597

3397598

3397599

3397600

3397606

3397607

3397608

3397609

3397610

3397611

3397622

3397623

3397633

3397640

3397645

57073_at

7952601

A_23_P127525

A_23_P329212

GE498575

GE55851

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001222

GO:0001228

GO:0002376

GO:0003676

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006954

GO:0006955

GO:0007155

GO:0008285

GO:0010595

GO:0010628

GO:0012501

GO:0030154

GO:0030374

GO:0030578

GO:0042802

GO:0042981

GO:0043226

GO:0043536

GO:0043565

GO:0045648

GO:0045765

GO:0045766

GO:0045786

GO:0045893

GO:0045944

GO:0046677

GO:0048856

GO:0048870

GO:0050729

GO:0061629

GO:0140110

GO:1902895

GO:1904996

GO:1990837

HMNXSV003002598

HMNXSV003005343

Hs.18063.0.S1_3p_at

Hs.248109.0.S1_3p_s_at

Hs2.18063.2.S1_3p_s_at

ILMN_1687538

ILMN_1900270

ILMN_2122103

J04101_at

PH_hs_0001623

TC11002439.hg

Participates

as an input of

Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)

as a component of

p-T38-ETS1:CDKN2A gene [nucleoplasm] (Homo sapiens)

as a member of

p-T38-ETS1/ p-T72-ETS2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ETS1 [nucleoplasm]

Inferred To

phospho-p-T38-ETS1 [nucleoplasm] (Canis familiaris)

phospho-p-T38-ETS1 [nucleoplasm] (Gallus gallus)

phospho-p-T38-ETS1 [nucleoplasm] (Sus scrofa)

phospho-Ets1 [nucleoplasm] (Mus musculus)

phospho-Ets1 [nucleoplasm] (Rattus norvegicus)

phospho-zgc:92106 [nucleoplasm] (Danio rerio)

phospho-ETS1 [nucleoplasm] (Bos taurus)

phospho-ets1 [nucleoplasm] (Xenopus tropicalis)

phospho-pnt [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 38

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001155894.1, XP_016872803.1, NP_005229.1, NP_001137292.1, NP_001317380.1

OpenTargets

ENSG00000134954

GeneCards

P14921

HPA

ENSG00000134954-ETS1

Ensembl

ENST00000319397, ENSP00000376436, ENST00000535549, ENST00000392668, ENSP00000441430, ENSP00000324578, ENSP00000433500, ENST00000531611, ENST00000526145, ENSG00000134954, ENSP00000435666

PRO

P14921

Pharos - Targets

P14921

Orphanet

22428

PDB

5ZMC, 3WTS, 3WTW, 4L18, 4L0Z, 3WU0, 3WTY, 2STT, 1GVJ, 2NNY, 3WTT, 4LG0, 3RI4, 3WTX, 3MFK, 3WTZ, 3WTU, 3WU1, 2STW, 3WTV, 4L0Y

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05519 SRSF11	1	SRSF11 [nucleoplasm] (R-HSA-72058)	0.573	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.536	2
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.536	2
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.528	3
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.525	2
UniProt:Q9BQA9 CYBC1			0.524	3
UniProt:Q4LE39 ARID4B	1	ARID4B [nucleoplasm] (R-HSA-2976647)	0.524	2
UniProt:O60841 EIF5B	1	EIF5B [cytosol] (R-HSA-72501)	0.524	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.524	3
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.508	4
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.499	2
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.499	2
UniProt:P31314 TLX1			0.463	3
UniProt:O43711 TLX3			0.463	3

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