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XRCC6 [cytosol]
Stable Identifier
R-HSA-3134813
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATP-dependent DNA helicase II, 70 kDa subunit, KU70, Lupus Ku autoantigen protein p70, 70 kDa subunit of Ku antigen, Thyroid-lupus autoantigen, TLAA, CTC box binding factor 75 kDa subunit, CTCBF, CTC75
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DNA-PK binds microbial dsDNA (Homo sapiens)
DNA-PK:microbial dsDNA [cytosol] (Homo sapiens)
Ku70:Ku80 heterodimer [cytosol] (Homo sapiens)
XRCC6 [cytosol] (Homo sapiens)
Ku70:Ku80 heterodimer [cytosol] (Homo sapiens)
XRCC6 [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
DNA-PK:microbial dsDNA [cytosol] (Homo sapiens)
Ku70:Ku80 heterodimer [cytosol] (Homo sapiens)
XRCC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12956 XRCC6
Gene Names
XRCC6, G22P1
Chain
initiator methionine:1, chain:2-609
Reference Genes
BioGPS Gene:2547 XRCC6
COSMIC (genes):XRCC6 XRCC6
CTD Gene:2547 XRCC6
dbSNP Gene:2547 XRCC6
ENSEMBL:ENSG00000196419 XRCC6
HGNC:4055 XRCC6
KEGG Gene (Homo sapiens):2547 XRCC6
Monarch:2547 XRCC6
NCBI Gene:2547 XRCC6
OMIM:152690 XRCC6
UCSC:P12956 XRCC6
Reference Transcript
RefSeq:NM_001469.4 XRCC6
RefSeq:NM_001288977.1 XRCC6
RefSeq:NM_001288976.1 XRCC6
Other Identifiers
0001340164
11730714_s_at
11754932_x_at
16930678
1JEQ
1JEY
1JJR
200792_at
2547
32766_at
3300572
3946972
3946973
3946974
3946975
3946976
3946978
3946981
3946982
3946984
3946987
3946989
3946990
3946993
3946994
3946995
3946997
3946998
3946999
3RZX
4025651
4025653
4025656
4025659
4025661
4025663
4254
47549
5Y3R
62226
6ERF
6ERG
6ERH
8073457
A0A024R1N4
A_23_P120942
A_23_P120947
AAA36155
AAA51733
AAA61177
AAB22381
AAH08343
AAH10034
AAH12154
AAH18259
AAH72449
AAW34364
AK055786
AY870329
B1AHC9
BAG51575
BC008343
BC010034
BC012154
BC018259
BC072449
CAB004254
CAG47015
CCDS14021
CCDS74870
CH471095
CR542219
EAW60446
EAW60447
EAW60448
ENSG00000196419
ENSP00000352257
ENSP00000353192
ENSP00000384257
ENSP00000384941
ENST00000359308
ENST00000359308.8
ENST00000360079
ENST00000360079.7
ENST00000402580
ENST00000402580.7
ENST00000405878
ENST00000405878.5
EntrezGene:2547
EntrezGene:XRCC6
g4503840_3p_at
GE61354
GE81028
GO:0000166
GO:0000228
GO:0000723
GO:0000783
GO:0000784
GO:0002218
GO:0002376
GO:0003674
GO:0003677
GO:0003684
GO:0003690
GO:0003691
GO:0003723
GO:0003824
GO:0004003
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006259
GO:0006266
GO:0006281
GO:0006303
GO:0006310
GO:0006464
GO:0006810
GO:0006950
GO:0006974
GO:0007420
GO:0008022
GO:0008150
GO:0008152
GO:0008283
GO:0009058
GO:0016020
GO:0016192
GO:0016787
GO:0016829
GO:0016887
GO:0022607
GO:0030332
GO:0031410
GO:0032481
GO:0032508
GO:0032991
GO:0032993
GO:0034641
GO:0034774
GO:0042162
GO:0042592
GO:0043167
GO:0043226
GO:0043312
GO:0043564
GO:0044212
GO:0044403
GO:0044877
GO:0045087
GO:0045860
GO:0045892
GO:0045893
GO:0045944
GO:0048660
GO:0048856
GO:0051276
GO:0051290
GO:0051575
GO:0065003
GO:0070419
GO:0071475
GO:0071480
GO:0071481
GO:0075713
GO:0097680
GO:1904813
HGNC:4055
HPA047549
HPA062226
ILMN_1743097
ILMN_2166506
IPR003034
IPR005160
IPR005161
IPR006164
IPR006165
IPR016194
IPR027388
IPR036361
IPR036465
J04607
J04611
J04611_at
M32865
MIM:152690
NM_001288976
NM_001288977
NM_001469
NP_001275905
NP_001275906
NP_001460
PF02037
PF02735
PF03730
PF03731
PH_hs_0022800
S38729
SM00513
SM00559
TC22000339.hg
UPI0000000C8F
UPI00003717DE
XRCC6
XRCC6-201
XRCC6-202
XRCC6-203
XRCC6-205
Z83840
Participant Of
hasComponent
Ku70:Ku80 heterodimer [cytosol]
Other forms of this molecule
XRCC6 [secretory granule lumen]
XRCC6 [extracellular region]
XRCC6 [ficolin-1-rich granule lumen]
XRCC6 [nucleoplasm]
Cross References
RefSeq
NP_001275905.1
,
NP_001460.1
,
NP_001275906.1
OpenTargets
ENSG00000196419
GeneCards
P12956
PRO
P12956
PDB
1JEY
,
6ERF
,
1JEQ
,
6ERH
,
3RZX
,
1JJR
,
5Y3R
,
6ERG
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.87
7
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
SUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.864
9
UniProt:P09874 PARP1
4
SUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
SUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.757
7
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.667
7
UniProt:Q13426 XRCC4
2
XRCC4 [nucleoplasm]
(R-HSA-75911)
SUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
0.656
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.508
3
UniProt:Q96P48 ARAP1
2
ARAP1 [cytosol]
(R-HSA-3211582)
p-Y231-ARAP1 [cytosol]
(R-HSA-8848869)
0.508
2
UniProt:P22415 USF1
1
USF1 [nucleoplasm]
(R-HSA-9023562)
0.462
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.462
3
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