Reactome | p-S552-CTNNB1 [nucleoplasm]

p-S552-CTNNB1 [nucleoplasm]

Stable Identifier

R-HSA-3134926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S552-catenin beta-1, CTNB1_HUMAN, CTNNB1

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9UI47 CTNA3

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External Reference Information

External Reference

UniProt:P35222 CTNNB1

Gene Names

CTNNB1, CTNNB, OK/SW-cl.35, PRO2286

Chain

initiator methionine:1, chain:2-781

Reference Genes

BioGPS Gene:1499 CTNNB1

COSMIC (genes):CTNNB1 CTNNB1

CTD Gene:1499 CTNNB1

dbSNP Gene:1499 CTNNB1

ENSEMBL:ENSG00000168036 CTNNB1

HGNC:2514 CTNNB1

KEGG Gene (Homo sapiens):1499 CTNNB1

Monarch:1499 CTNNB1

NCBI Gene:1499 CTNNB1

OMIM:116806 CTNNB1

UCSC:P35222 CTNNB1

Reference Transcript

Other Identifiers

0001990132

108

11722167_s_at

11747387_a_at

11747388_x_at

11748951_a_at

11748952_x_at

11749021_s_at

11749022_x_at

11750680_x_at

1499

1554411_at

16939558

1950

1G3J

1JDH

1JPW

1LUJ

1P22

1QZ7

1T08

1TH1

201533_at

2618941

2618942

2618945

2618946

2618952

2618953

2618955

2618957

2618958

2618959

2618960

2618961

2618962

2618965

2618967

2618969

2618971

2618973

2618975

2618978

2618980

2618981

2618982

2618983

29159

29160

2G57

2GL7

2Z6H

3DIW

3FQN

3FQR

3SL9

3SLA

3TX7

40777_at

4DJS

6M90

6M91

6M92

6M93

6M94

8079021

A0A024R2Q3

A0A2R8Y543

A0A2R8Y5A3

A0A2R8Y5C3

A0A2R8Y5Z1

A0A2R8Y750

A0A2R8Y7Z0

A0A2R8Y804

A0A2R8Y815

A0A2R8YCH5

A_14_P106050

A_14_P131897

A_23_P29495

A_23_P29499

A_33_P3421695

AAG35511

AAH58926

AAL89457

AAR18817

AB062292

AC104307

AF130085

AK289932

AY081165

AY463360

B4DGU4

BAB93475

BAF82621

BC058926

C9IZ65

C9JV16

CAA61107

CAA79497

CAB000108

CAB001950

CCDS2694

CH471055

CTNNB1

CTNNB1-201

CTNNB1-202

CTNNB1-203

CTNNB1-204

CTNNB1-206

CTNNB1-207

CTNNB1-208

CTNNB1-209

CTNNB1-216

CTNNB1-217

CTNNB1-218

CTNNB1-222

CTNNB1-223

CTNNB1-225

CTNNB1-226

CTNNB1-228

CTNNB1-229

CTNNB1-235

CTNNB1-238

CTNNB1-241

CTNNB1-246

CTNNB1-250

CTNNB1-252

CTNNB1-255

E7EMJ5

E7EV28

E9PDF9

EAW64625

EAW64626

EAW64627

EAW64628

ENSG00000168036

ENSP00000344456

ENSP00000379486

ENSP00000379488

ENSP00000385604

ENSP00000387455

ENSP00000401599

ENSP00000409302

ENSP00000412219

ENSP00000493533

ENSP00000493610

ENSP00000494053

ENSP00000494411

ENSP00000494677

ENSP00000494845

ENSP00000494914

ENSP00000495076

ENSP00000495244

ENSP00000495360

ENSP00000495450

ENSP00000495719

ENSP00000495992

ENSP00000496021

ENSP00000496180

ENSP00000496385

ENST00000349496

ENST00000349496.10

ENST00000396183

ENST00000396183.7

ENST00000396185

ENST00000396185.8

ENST00000405570

ENST00000405570.6

ENST00000431914

ENST00000431914.6

ENST00000433400

ENST00000433400.6

ENST00000441708

ENST00000441708.2

ENST00000450969

ENST00000450969.6

ENST00000642248

ENST00000642248.1

ENST00000642315

ENST00000642315.1

ENST00000642426

ENST00000642426.1

ENST00000642992

ENST00000642992.1

ENST00000643031

ENST00000643031.1

ENST00000643297

ENST00000643297.1

ENST00000643541

ENST00000643541.1

ENST00000643977

ENST00000643977.1

ENST00000643992

ENST00000643992.1

ENST00000644867

ENST00000644867.1

ENST00000645210

ENST00000645210.1

ENST00000645320

ENST00000645320.1

ENST00000645982

ENST00000645982.1

ENST00000646369

ENST00000646369.1

ENST00000646725

ENST00000646725.1

ENST00000647390

ENST00000647390.1

EntrezGene:1499

EntrezGene:CTNNB1

g4503130_3p_at

GE60116

GE752547

GO:0000003

GO:0000122

GO:0000209

GO:0000228

GO:0000278

GO:0000578

GO:0000902

GO:0000904

GO:0000922

GO:0001085

GO:0001102

GO:0001501

GO:0001569

GO:0001570

GO:0001658

GO:0001701

GO:0001702

GO:0001706

GO:0001708

GO:0001709

GO:0001711

GO:0001764

GO:0001822

GO:0001837

GO:0001840

GO:0001894

GO:0001944

GO:0002052

GO:0002053

GO:0002089

GO:0002376

GO:0003266

GO:0003338

GO:0003340

GO:0003674

GO:0003682

GO:0003700

GO:0003713

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005719

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005912

GO:0005913

GO:0005916

GO:0005923

GO:0005925

GO:0005938

GO:0006259

GO:0006357

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007049

GO:0007059

GO:0007155

GO:0007160

GO:0007165

GO:0007223

GO:0007267

GO:0007268

GO:0007398

GO:0007399

GO:0007403

GO:0007507

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009056

GO:0009058

GO:0009790

GO:0009948

GO:0009950

GO:0009953

GO:0009954

GO:0009987

GO:0010468

GO:0010628

GO:0010629

GO:0010718

GO:0010909

GO:0014704

GO:0016020

GO:0016032

GO:0016055

GO:0016192

GO:0016323

GO:0016328

GO:0016331

GO:0016342

GO:0016525

GO:0016600

GO:0019827

GO:0019899

GO:0019900

GO:0019901

GO:0019903

GO:0021700

GO:0021819

GO:0022009

GO:0022405

GO:0022607

GO:0030018

GO:0030027

GO:0030054

GO:0030097

GO:0030154

GO:0030182

GO:0030217

GO:0030316

GO:0030324

GO:0030331

GO:0030521

GO:0030539

GO:0030856

GO:0030858

GO:0030877

GO:0030900

GO:0030901

GO:0030902

GO:0030997

GO:0031016

GO:0031069

GO:0031253

GO:0031528

GO:0031641

GO:0032212

GO:0032331

GO:0032355

GO:0032481

GO:0032991

GO:0032993

GO:0033077

GO:0033234

GO:0034330

GO:0034332

GO:0034333

GO:0034394

GO:0034613

GO:0034641

GO:0034750

GO:0035050

GO:0035112

GO:0035115

GO:0035116

GO:0035257

GO:0035315

GO:0035635

GO:0036023

GO:0040007

GO:0040011

GO:0042127

GO:0042129

GO:0042475

GO:0042493

GO:0042592

GO:0042733

GO:0042734

GO:0042981

GO:0042995

GO:0043065

GO:0043066

GO:0043123

GO:0043161

GO:0043226

GO:0043296

GO:0043410

GO:0043525

GO:0043588

GO:0044093

GO:0044325

GO:0044334

GO:0044336

GO:0044403

GO:0044798

GO:0045177

GO:0045202

GO:0045211

GO:0045294

GO:0045296

GO:0045453

GO:0045595

GO:0045596

GO:0045603

GO:0045667

GO:0045669

GO:0045670

GO:0045671

GO:0045743

GO:0045765

GO:0045892

GO:0045893

GO:0045944

GO:0045976

GO:0046332

GO:0048096

GO:0048145

GO:0048469

GO:0048471

GO:0048489

GO:0048513

GO:0048538

GO:0048599

GO:0048617

GO:0048643

GO:0048646

GO:0048660

GO:0048715

GO:0048856

GO:0048870

GO:0050681

GO:0050767

GO:0050768

GO:0050808

GO:0051091

GO:0051145

GO:0051149

GO:0051276

GO:0051571

GO:0051884

GO:0051973

GO:0060066

GO:0060070

GO:0060173

GO:0060439

GO:0060440

GO:0060441

GO:0060479

GO:0060484

GO:0060492

GO:0060742

GO:0060769

GO:0060789

GO:0060828

GO:0060916

GO:0061047

GO:0061154

GO:0061198

GO:0061324

GO:0061549

GO:0061550

GO:0065003

GO:0070062

GO:0070369

GO:0070411

GO:0070491

GO:0070602

GO:0071363

GO:0071681

GO:0071944

GO:0072033

GO:0072053

GO:0072054

GO:0072079

GO:0072182

GO:0090279

GO:0097091

GO:0097718

GO:0098609

GO:0098685

GO:0098831

GO:0099092

GO:1901215

GO:1903204

GO:1904501

GO:1904793

GO:1904796

GO:1904798

GO:1904837

GO:1904886

GO:1904888

GO:1904948

GO:1904954

GO:1990138

GO:1990403

GO:1990791

GO:1990907

GO:1990909

GO:2000008

GO:2000017

GO:2000144

GO:2000179

GO:2001234

HGNC:2514

HPA029159

HPA029160

Hs2.171271.2.S1_3p_s_at

ILMN_1651617

ILMN_1726641

ILMN_1746396

ILMN_1757350

IPR000225

IPR011989

IPR013284

IPR016024

MIM:114500

MIM:114550

MIM:116806

MIM:132600

MIM:155255

MIM:167000

MIM:615075

MIM:617572

NM_001098209

NM_001098210

NM_001904

NP_001091679

NP_001091680

NP_001895

PF00514

PH_hs_0024820

PR01869

SM00185

TC03000214.hg

UPI000012862F

X87838

X87838_at

XM_017005738

XM_024453356

XM_024453357

XM_024453358

XP_016861227

XP_024309124

XP_024309125

XP_024309126

Z19054

Participant Of

hasComponent

beta-catenin:IRF3:p300 [nucleoplasm]

input

Beta-catenin enhances association of IRF3 with CBP/p300

output

Beta-catenin migrates to the nucleus

Other forms of this molecule

CTNNB1 S45A [cytosol]

CTNNB1 S45F [cytosol]

CTNNB1 S45C [cytosol]

CTNNB1 S45Y [cytosol]

CTNNB1 S45N [cytosol]

CTNNB1 S45P [cytosol]

pT41,S45-CTNNB1 S37P [cytosol]

pT41,S45-CTNNB1 S37F [cytosol]

pT41,S45-CTNNB1 S37A [cytosol]

pT41,S45-CTNNB1 S37Y [cytosol]

pT41,S45-CTNNB1 S37C [cytosol]

pS37,T41,S45-CTNNB1 S33A [cytosol]

pS37,T41,S45-CTNNB1 S33T [cytosol]

pS37,T41,S45-CTNNB1 S33C [cytosol]

pS37,T41,S45-CTNNB1 S33F [cytosol]

pS37,T41,S45-CTNNB1 S33P [cytosol]

pS37,T41,S45-CTNNB1 S33Y [cytosol]

pS45-CTNNB1 T41N [cytosol]

pS45-CTNNB1 T41A [cytosol]

pS45-CTNNB1 T41I [cytosol]

Ub-K,p-Y-CTNNB1 [cytosol]

p-Y-CTNNB1 [cytosol]

CTNNB1(116-376) [cytosol]

CTNNB1(1-115) [cytosol]

p-S552-CTNNB1 [cytosol]

CTNNB1 [plasma membrane]

p-S45 CTNNB1 [cytosol]

p-T41,S45 CTNNB1 [cytosol]

p-S37,T41,S45, CTNNB1 [cytosol]

p-S33,S37,T41,S45 CTNNB1 [cytosol]

CTNNB1 [cytosol]

CTNNB1 [nucleoplasm]

Inferred To

phospho-p-S552-CTNNB1 [nucleoplasm] (Bos taurus)

phospho-p-S552-CTNNB1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S552-CTNNB1 [nucleoplasm] (Canis familiaris)

phospho-p-S552-CTNNB1 [nucleoplasm] (Danio rerio)

phospho-p-S552-CTNNB1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S552-CTNNB1 [nucleoplasm] (Gallus gallus)

phospho-p-S552-CTNNB1 [nucleoplasm] (Mus musculus)

phospho-p-S552-CTNNB1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S552-CTNNB1 [nucleoplasm] (Sus scrofa)

phospho-p-S552-CTNNB1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 552

Coordinate

552

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001091679.1, NP_001091680.1, XP_016861227.1, XP_005264943.1, NP_001895.1

OpenTargets

ENSG00000168036

GeneCards

P35222

ZINC - Substances

CTNB1_HUMAN

ZINC target

P35222

PRO

P35222

ZINC - Predictions - Purchasable

CTNB1_HUMAN

Orphanet

15819

HMDB Protein

HMDBP02169

PDB

6M92, 1TH1, 3SLA, 2GL7, 1T08, 1QZ7, 1P22, 1LUJ, 1JDH, 3FQN, 6M93, 2Z6H, 6M94, 3FQR, 6M90, 4DJS, 3DIW, 1JPW, 1G3J, 6M91, 2G57, 3TX7, 3SL9

Interactors (89)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) TCF7L2 K485fs25* [nucleoplasm] (R-HSA-5334040) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.97	27
UniProt:P25054 APC	86	APC C1410* [cytosol] (R-HSA-9666925) APC R213* [cytosol] (R-HSA-9666924) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930) APC G1312* [cytosol] (R-HSA-9666931) APC R283* [cytosol] (R-HSA-9666988) APC Q1367* [cytosol] (R-HSA-9666989) APC E1353* [cytosol] (R-HSA-9666990) APC R332* [cytosol] (R-HSA-9666991) APC K993* [cytosol] (R-HSA-9666984) APC R876* [cytosol] (R-HSA-9666985) APC R302* [cytosol] (R-HSA-9666986) APC E1309* [cytosol] (R-HSA-9666987) APC Y935* [cytosol] (R-HSA-9666980) APC E1286* [cytosol] (R-HSA-9666981) APC Q1378* [cytosol] (R-HSA-9666982) APC R554* [cytosol] (R-HSA-9666983) APC S1356* [cytosol] (R-HSA-9666976) APC R232* [cytosol] (R-HSA-9666977) APC E1379* [cytosol] (R-HSA-9666978) APC E984* [cytosol] (R-HSA-9666979) APC R1114* [cytosol] (R-HSA-9666996) APC S1282* [cytosol] (R-HSA-9666997) APC Q1328* [cytosol] (R-HSA-9666998) APC E1295* [cytosol] (R-HSA-9666992) APC E1151* [cytosol] (R-HSA-9666993) APC E1322* [cytosol] (R-HSA-9666994) APC E1345* [cytosol] (R-HSA-9666995) APC K1308* [cytosol] (R-HSA-9666956) APC S1344* [cytosol] (R-HSA-9666957) APC E1577* [cytosol] (R-HSA-9666958) APC Q1127* [cytosol] (R-HSA-9666959) APC E1464* [cytosol] (R-HSA-9666952) APC E1317* [cytosol] (R-HSA-9666953) APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC W1049 [cytosol] (R-HSA-9666954) APC Q1429* [cytosol] (R-HSA-9666955) APC L1564* [cytosol] (R-HSA-9666948) APC Q1294* [cytosol] (R-HSA-9666949) APC K1363* [cytosol] (R-HSA-9666950) APC E1408* [cytosol] (R-HSA-9666951) APC E1284* [cytosol] (R-HSA-9666944) APC E1374* [cytosol] (R-HSA-9666945) APC Q767* [cytosol] (R-HSA-9666946) APC E941* [cytosol] (R-HSA-9666947) APC Q1303* [cytosol] (R-HSA-9666972) APC S943* [cytosol] (R-HSA-9666973) APC E1306* [cytosol] (R-HSA-9666975) APC S895* [cytosol] (R-HSA-9666969) APC S1315* [cytosol] (R-HSA-9666970) APC G1412* [cytosol] (R-HSA-9666971) APC Y1376* [cytosol] (R-HSA-9666964) APC Q886* [cytosol] (R-HSA-9666965) APC S1392* [cytosol] (R-HSA-9666966) APC S1539* [cytosol] (R-HSA-9666967) APC E1451* [cytosol] (R-HSA-9666960) APC E1397* [cytosol] (R-HSA-9666961) APC Q1406* [cytosol] (R-HSA-9666962) APC E1544* [cytosol] (R-HSA-9666963) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755)	0.955	19
UniProt:P12830 CDH1	10	CDH1(751-882) [plasma membrane] (R-HSA-3827962) CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-750) [plasma membrane] (R-HSA-3828000) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940)	0.951	15
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.95	19
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.948	14
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.94	22
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512)	0.94	44
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.926	8
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.893	10
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.891	15
UniProt:P19022 CDH2	3	CDH2 [endoplasmic reticulum lumen] (R-HSA-8956761) p-CDH2 [endoplasmic reticulum lumen] (R-HSA-8956899) CDH2 [plasma membrane] (R-HSA-191429)	0.887	8
UniProt:P46937 YAP1	7	p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345)	0.881	14
UniProt:P33151 CDH5	2	VE-cadherin [plasma membrane] (R-HSA-418992) p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435)	0.857	7
UniProt:P36402 TCF7	1	TCF7 [nucleoplasm] (R-HSA-3299543)	0.779	4
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.758	4
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.723	4
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.714	10
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.713	3
UniProt:Q5JTC6 AMER1	5	AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.711	9
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.696	7
UniProt:O35625 Axin1	8	ub-AXIN1 [cytosol] (R-MMU-4641133) Phospho Axin1 [cytosol] (R-MMU-206175) phospho-Ub-RibC-AXIN1 [cytosol] (R-MMU-3640864) phospho-RibC-AXIN1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-p-T519,S524,S531-AXIN1 [cytosol] (R-MMU-206040) AXIN1 [cytosol] (R-MMU-195249)	0.688	4
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.681	13
UniProt:Q08050 FOXM1	3	p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019) p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133)	0.672	16
UniProt:P14923 JUP	5	JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260) JUP [extracellular region] (R-HSA-6806309) JUP [specific granule lumen] (R-HSA-6799534) JUP [cornified envelope] (R-HSA-8847739)	0.669	3
UniProt:P19838 NFKB1	8	p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.667	3
UniProt:Q01826 SATB1	5	SUMO1-K744-SATB1 [nucleoplasm] (R-HSA-4615954) SUMO2,3-K744-SATB1 [nucleoplasm] (R-HSA-4615978) SATB1 [nucleoplasm] (R-HSA-201593) SATB1(1-254) [nucleoplasm] (R-HSA-352269) SATB1(255-763) [nucleoplasm] (R-HSA-352264)	0.66	9
UniProt:P55197 AF10			0.656	5
UniProt:Q13761 RUNX3	7	p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.656	12
UniProt:O00482-1 NR5A2	1	NR5A2-1 [nucleoplasm] (R-HSA-3008758)	0.65	5
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.641	4
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) SUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.628	8
UniProt:Q9YGY0 AXIN1			0.609	2
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.609	2
UniProt:P23470 PTPRG			0.609	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.609	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674)	0.602	5
UniProt:Q9UI47-1 CTNNA3			0.602	4
UniProt:P49789 FHIT			0.602	4
UniProt:P18012 IPAC			0.602	4
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.602	4
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.602	4
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.591	3
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.589	2
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.589	2
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642)	0.589	3
UniProt:Q13308 PTK7			0.581	5
UniProt:Q9BZE0 GLIS2			0.581	6
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.576	5
IntAct:EBI-4399559 UBIQ			0.576	3
UniProt:O75564 JERKY			0.576	3
UniProt:Q92793 CREBBP	3	FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) CREBBP [nucleoplasm] (R-HSA-193545)	0.573	2
UniProt:P33724	5	CAV1 [endocytic vesicle membrane] (R-CFA-535009) CAV1 [Golgi membrane] (R-CFA-204504) CAV1 [lipid droplet] (R-CFA-163510) CAV1 [early endosome membrane] (R-CFA-5368451) CAV1 [plasma membrane] (R-CFA-534994)	0.571	5
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.57	5
UniProt:Q8TEK3 DOT1L	1	DOT1L [nucleoplasm] (R-HSA-3239030)	0.564	3
UniProt:Q9UI47 CTNA3			0.564	2
UniProt:Q9Y2T1 AXIN2	4	RibC-AXIN2 [cytosol] (R-HSA-3640842) AXIN2 [cytosol] (R-HSA-3640821) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.564	2
UniProt:P16284 PECAM1	4	PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [plasma membrane] (R-HSA-114686)	0.564	3
UniProt:Q99697 PITX2	1	PITX2 [nucleoplasm] (R-HSA-8864726)	0.564	2
UniProt:Q9DBG9	1	TAX1BP3 [cytosol] (R-MMU-5666217)	0.558	3
UniProt:P00519 ABL1	5	ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.544	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.544	2
UniProt:Q03431 PTH1R	1	PTH1R [plasma membrane] (R-HSA-420479)	0.543	4
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.537	3
IntAct:EBI-5237192 AXIN2			0.527	2
UniProt:P09803 Cdh1	6	CDH1(155-700) [plasma membrane] (R-MMU-2534244) Epithelial-cadherin precursor [plasma membrane] (R-MMU-199081) CDH1(701-882) [extracellular region] (R-MMU-2534158) CDH1(155-750) [plasma membrane] (R-MMU-202940) CDH1(751-882) [plasma membrane] (R-MMU-202929) CDH1(155-882) [plasma membrane] (R-MMU-198003)	0.527	3
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.525	3
UniProt:Q9EPK5 Wwtr1	4	phospho-p-S89-WWTR1 [cytosol] (R-MMU-2028665) Wwtr1 [nucleoplasm] (R-MMU-2064930) WWTR1 [nucleoplasm] (R-MMU-1629775) WWTR1 [cytosol] (R-MMU-1629773)	0.525	2
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.524	3
UniProt:A1Z199 A1Z199			0.524	2
UniProt:P14618-1 PKM	1	PKM-1 [cytosol] (R-HSA-71667)	0.524	3
UniProt:Q9JHQ5	1	LZTFL1 [cytosol] (R-MMU-5617789)	0.524	2
UniProt:P14618 PKM	3	PKM [extracellular region] (R-HSA-6806491) PKM [secretory granule lumen] (R-HSA-6801401) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.524	4
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.524	2
UniProt:P29474 NOS3	7	MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) NOS3 [cytosol] (R-HSA-202114) MyrG-NOS3 [cytosol] (R-HSA-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139)	0.524	4
UniProt:Q15599 NHRF2			0.508	2
UniProt:O00512 BCL9	1	BCL9 [nucleoplasm] (R-HSA-201714)	0.508	2
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.499	3
IntAct:EBI-6668710 TCF			0.499	3
UniProt:P18146 EGR1	1	EGR1 [nucleoplasm] (R-HSA-1031703)	0.499	7
UniProt:Q9H6I2 SOX17	1	SOX17 [nucleoplasm] (R-HSA-5625834)	0.499	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.499	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.499	2
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.499	3
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.463	2
UniProt:O95071 UBR5			0.463	6
UniProt:Q14526 HIC1	2	HIC1 [nucleoplasm] (R-HSA-4090364) SUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368)	0.463	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.463	3
UniProt:P11279 LAMP1	3	LAMP1 [plasma membrane] (R-HSA-6806268) LAMP1 [ficolin-1-rich granule membrane] (R-HSA-6800966) LAMP1 [azurophil granule membrane] (R-HSA-6799162)	0.462	2
UniProt:Q99593 TBX5	1	TBX5 [nucleoplasm] (R-HSA-2032786)	0.462	3