LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

Stable Identifier
R-HSA-3134973
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Pathway
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Homo sapiens
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Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) can bind exogenous double-stranded RNA and double-stranded DNA (Wilson SA et al. 1998; Yang P et al. 2010). LRRFIP1 was shown to mediate Listeria monocytogenes- and vesicular stomatitis virus (VSV)-induced IFN-beta production in mouse primary macrophages by regulating beta-catenin activity. Beta-catenin possibly functions as a transcriptional cofactor of IRF3 to initiate Ifnb1 transcription (Yang P et al. 2010).

Literature References
PubMed ID Title Journal Year
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Yang, P, An, H, Liu, X, Wen, M, Zheng, Y, Rui, Y, Cao, X

Nat. Immunol. 2010
9671805 TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I

Wilson, SA, Brown, EC, Kingsman, AJ, Kingsman, SM

Nucleic Acids Res. 1998
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