Maturation of HIV Virion

Stable Identifier
R-HSA-3139027
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Maturation of HIV Virion
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The proteolytic events that cleave Gag and Gag-Pro-Pol are well characterized, but the event that triggers the protease is not well characterized. The PRGag, that is assembled in the immature virion weakly dimerizes, once PR is cleaved from the proprotein PR dimerizes and becomes an efficient protease. This assembly step may be part of the switch. Once the protease becomes active in the immature virion MA, CA, SP1, NC, SP2, P6, PR, RT, and IN are produced. This event, the production of these fragments would be the switch from immature to mature.
Literature References
PubMed ID Title Journal Year
22762019 HIV-1 Assembly, Budding, and Maturation

Sundquist, WI, Kräusslich, HG

Cold Spring Harb Perspect Med 2012
23266279 HIV Gag polyprotein: processing and early viral particle assembly

Lever, AM, Bell, NM

Trends Microbiol. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptidase activity of GAG-POL Polyprotein (P04585) [extracellular region]

Physical Entity
GAG-POL Polyprotein (P04585) [extracellular region] (Human immunodeficiency virus 1)
Activity
peptidase activity (GO:0008233)
This event is regulated
Negatively by
Regulator
Protease:Protease inhibitors [extracellular region] (Human immunodeficiency virus 1)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2013-03-07)
Reviewed
Dube, M  (2013-05-21)
Created
Gillespie, ME  (2013-02-13)
Cite Us!