Reactome | MRE11 binds cytosolic DNA

MRE11 binds cytosolic DNA

Stable Identifier

R-HSA-3204303

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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DNA damage sensor, meiotic recombination 11 homolog A (MRE11) has been shown to function as a cytosolic sensor of dsDNA. The observations that MRE11 mediates recognition of dsDNA rather than pathogens suggest that the biological significance of MRE11-mediated intracellular DNA recognition is to respond to damaged host cells, rather than defense against foreign pathogens (Kondo T et al. 2013). Cells with a mutation of MRE11 gene derived from a patient with ataxia-telangiectasia-like disorder, and cells in which Mre11 was knocked down, had defects in dsDNA-induced type I IFN production (Kondo T et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23388631	DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking Kondo, T, Kobayashi, J, Saitoh, T, Maruyama, K, Ishii, KJ, Barber, GN, Komatsu, K, Akira, S, Kawai, T	Proc. Natl. Acad. Sci. U.S.A.	2013