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MRE11A [cytosol]
Stable Identifier
R-HSA-3204309
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Double-strand break repair protein MRE11A, MRE11 homolog 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
MRE11 binds cytosolic DNA (Homo sapiens)
MRE11:dsDNA [cytosol] (Homo sapiens)
MRE11A [cytosol] (Homo sapiens)
MRE11A [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
MRE11:dsDNA [cytosol] (Homo sapiens)
MRE11A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49959 MRE11
Gene Names
MRE11, HNGS1, MRE11A
Chain
initiator methionine:, chain:2-708
Reference Genes
BioGPS Gene:4361 MRE11
COSMIC (genes):MRE11 MRE11
CTD Gene:4361 MRE11
dbSNP Gene:4361 MRE11
ENSEMBL:ENSG00000020922 MRE11
ENSEMBL_homo_sapiens_GENE:ENSG00000020922.13 MRE11
HGNC:7230 MRE11
KEGG Gene (Homo sapiens):4361 MRE11
Monarch:4361 MRE11
NCBI Gene:4361 MRE11
OMIM:600814 MRE11
UCSC:P49959 MRE11
Reference Transcript
RefSeq:XM_017017772.1 MRE11
RefSeq:NM_005591.3 MRE11
RefSeq:XM_011542837.2 MRE11
RefSeq:NM_005590.3 MRE11
Other Identifiers
11725791_a_at
11725792_a_at
11730403_a_at
11750484_a_at
16743374
205395_PM_s_at
205395_s_at
242456_PM_at
242456_at
2702024
2702027
2702028
32869_at
32870_g_at
3387028
3387030
3387032
3387034
3387035
3387036
3387037
3387038
3387039
3387041
3387043
3387047
3387048
3387051
3387052
3387053
3387055
3387057
3387060
3387061
3387064
3387065
3387066
3387067
3387068
3387071
3387073
3387074
3387075
3387076
3387077
3387078
39233_at
4361
46774_i_at
46775_r_at
73948_at
7951046
89605_at
A_23_P150189
A_24_P312671
GE59113
GO:0000014
GO:0000019
GO:0000278
GO:0000723
GO:0000724
GO:0000729
GO:0000781
GO:0003677
GO:0003678
GO:0003690
GO:0003824
GO:0004518
GO:0004519
GO:0004520
GO:0004527
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005829
GO:0006260
GO:0006281
GO:0006302
GO:0006303
GO:0006310
GO:0006974
GO:0007004
GO:0007059
GO:0007062
GO:0007095
GO:0007129
GO:0007131
GO:0008283
GO:0008296
GO:0008408
GO:0008409
GO:0012501
GO:0016605
GO:0016787
GO:0022414
GO:0023052
GO:0030145
GO:0030870
GO:0031573
GO:0031860
GO:0031954
GO:0032200
GO:0032206
GO:0032508
GO:0033674
GO:0035825
GO:0035861
GO:0036211
GO:0042138
GO:0042802
GO:0043066
GO:0043226
GO:0044818
GO:0045296
GO:0051276
GO:0051321
GO:0070533
GO:0097552
GO:0098687
GO:0110025
GO:0140013
GO:0140097
GO:0140657
HMNXSV003006654
HMNXSV003032205
Hs.125848.0.A1_3p_at
ILMN_1658636
ILMN_1709483
ILMN_1760802
PH_hs_0001780
TC11002199.hg
U37359_at
g5031920_3p_s_at
Participates
as a component of
MRE11:dsDNA [cytosol] (Homo sapiens)
as an input of
MRE11 binds cytosolic DNA (Homo sapiens)
Other forms of this molecule
MRE11A [nucleoplasm]
Inferred To
MRE11 [cytosol]
(Bos taurus)
MRE11 [cytosol]
(Canis familiaris)
MRE11 [cytosol]
(Saccharomyces cerevisiae)
MRE11 [cytosol]
(Sus scrofa)
rad32 [cytosol]
(Schizosaccharomyces pombe)
mre-11 [cytosol]
(Caenorhabditis elegans)
MRE11A [cytosol]
(Gallus gallus)
MRE11A [cytosol]
(Plasmodium falciparum)
mre11 [cytosol]
(Dictyostelium discoideum)
mre11 [cytosol]
(Drosophila melanogaster)
mre11 [cytosol]
(Xenopus tropicalis)
Mre11 [cytosol]
(Mus musculus)
Mre11 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011541139.1
,
XP_016873261.1
,
NP_005582.1
,
NP_005581.2
OpenTargets
ENSG00000020922
GeneCards
P49959
HPA
ENSG00000020922-MRE11
ZINC target
P49959
Ensembl
ENSP00000325863
,
ENSP00000326094
,
ENSG00000020922
,
ENST00000323977
,
ENST00000407439
,
ENST00000323929
,
ENSP00000385614
PRO
P49959
Pharos - Targets
P49959
Orphanet
16465
HMDB Protein
HMDBP08845
PDB
8BAH
,
3T1I
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60934 NBN
3
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
NBN [cytosol]
(R-HSA-5684005)
NBN [nucleoplasm]
(R-HSA-75163)
0.822
5
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.809
7
UniProt:Q92878 RAD50
1
RAD50 [nucleoplasm]
(R-HSA-75160)
0.777
6
UniProt:Q14676 MDC1
6
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
MDC1 [nucleoplasm]
(R-HSA-75231)
0.671
9
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.669
3
UniProt:Q9BXW9 FANCD2
3
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
FANCD2 [nucleoplasm]
(R-HSA-419522)
0.646
6
UniProt:P49959 MRE11
2
MRE11A [nucleoplasm]
(R-HSA-59544)
MRE11A [cytosol]
(R-HSA-3204309)
0.618
3
UniProt:P03243-1
0.589
2
UniProt:O75943 RAD17
1
RAD17 [nucleoplasm]
(R-HSA-3008665)
0.499
2
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