E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA

Stable Identifier
Reaction [omitted]
Homo sapiens
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E2F1, E2F2 or E2F3 in complex with SP1 stimulates p14ARF transcription (Parisi et al. 2002). Therefore, increased activity of E2F1, E2F2 or E2F3, which may result from the loss of function of the tumor suppressor protein RB1, an inhibitor of E2F1/2/3, leads to an increased level of p14ARF (Komori et al. 2005).

Literature References
PubMed ID Title Journal Year
16211008 Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

Komori, H, Enomoto, M, Nakamura, M, Iwanaga, R, Ohtani, K

EMBO J. 2005
11883935 Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors

Parisi, T, Pollice, A, Di Cristofano, A, CalabrĂ², V, La Mantia, G

Biochem. Biophys. Res. Commun. 2002
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