E2F1, E2F2 or E2F3 in complex with SP1 stimulates p14ARF transcription (Parisi et al. 2002). Therefore, increased activity of E2F1, E2F2 or E2F3, which may result from the loss of function of the tumor suppressor protein RB1, an inhibitor of E2F1/2/3, leads to an increased level of p14ARF (Komori et al. 2005).
Komori, H, Enomoto, M, Nakamura, M, Iwanaga, R, Ohtani, K
Parisi, T, Pollice, A, Di Cristofano, A, Calabrò, V, La Mantia, G
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