Phosphorylated ERF translocates to the cytosol

Stable Identifier
R-HSA-3209159
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of ERF at threonine T526 by activated ERKs triggers ERF export from the nucleus to the cytosol (Le Gallic et al. 2004), which is expected to relieve ERF-mediated inhibition of ETS2 transcription.

Literature References
PubMed ID Title Journal Year
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Le Gallic, L, Virgilio, L, Cohen, P, Biteau, B, Mavrothalassitis, G

Mol. Cell. Biol. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!