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TP53 Tetramer [nucleoplasm]
Stable Identifier
R-HSA-3209194
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
BANP binds TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53:BANP [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AMPK phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
AURKA phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
CDK2 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
CDK5 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
NUAK1 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TAF1 phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds HIPK1 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:HIPK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds STK11 and NUAK1 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53RK phosphorylates TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the CCNG1 gene (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:CCNG1 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates CCNG1 gene expression (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:CCNG1 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression (Homo sapiens)
TP53 forms homotetramers (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
PTEN gene transcription is stimulated by TP53 (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:PTEN Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the GLS2 promoter (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:GLS2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the PTEN promoter (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:PTEN Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the RRM2B gene (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:RRM2B Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the SCO2 gene (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SCO2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the TIGAR gene (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:TIGAR Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates GLS2 transcription (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:GLS2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates SCO2 gene transcription (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SCO2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates TIGAR expression (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:TIGAR Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 stimulates transcription of RRM2B gene (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:RRM2B Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP63/TP53 bind the DDIT4 gene promoter (Homo sapiens)
TP63 Tetramer/ TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP63/T53:DDIT4 Gene [nucleoplasm] (Homo sapiens)
TP63 Tetramer/ TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)
TP63 Tetramer/ TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP63/T53:DDIT4 Gene [nucleoplasm] (Homo sapiens)
TP63 Tetramer/ TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates CDKN1A transcription (Homo sapiens)
RUNX3 binds TP53 (Homo sapiens)
RUNX3:TP53 tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
p53, SIN3A and MYB form a complex (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p53:MYB:SIN3A [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates TP53 tetramer (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:PTEN Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 binds the PTEN promoter (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:PTEN Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
TP53 binds promoters of MIR34 genes (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:MIR34 genes [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)
TP53 Tetramer:MIR34 genes [nucleoplasm] (Homo sapiens)
TP53 Tetramer [nucleoplasm] (Homo sapiens)
Participants
components
x 4
TP53 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
Myb:SIN3A:p53 [nucleoplasm] (Homo sapiens)
p53:MYB:SIN3A [nucleoplasm] (Homo sapiens)
TP53 Tetramer:MIR34 genes [nucleoplasm] (Homo sapiens)
RUNX3:TP53 tetramer [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SCO2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer:SESN1,2,3 Genes [nucleoplasm] (Homo sapiens)
TP53 Tetramer:PTEN Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer:TIGAR Gene [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:GLS2 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer:CCNG1 Gene [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
TP53 Tetramer:HIPK1 [nucleoplasm] (Homo sapiens)
TP53:BANP [nucleoplasm] (Homo sapiens)
TP53 Tetramer:RRM2B Gene [nucleoplasm] (Homo sapiens)
as an input of
p53 and Sin3a bind c-Myb (Homo sapiens)
p53, SIN3A and MYB form a complex (Homo sapiens)
TP53 binds promoters of MIR34 genes (Homo sapiens)
RUNX3 binds TP53 (Homo sapiens)
TP53 binds the SCO2 gene (Homo sapiens)
TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)
TP53 binds the RRM2B gene (Homo sapiens)
TP53RK phosphorylates TP53 (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATM phosphorylates TP53 at S15 (Homo sapiens)
AMPK phosphorylates TP53 (Homo sapiens)
TP53 binds the TIGAR gene (Homo sapiens)
TP53 binds the PTEN promoter (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
TP53 binds the GLS2 promoter (Homo sapiens)
TP53 binds the CCNG1 gene (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
TAF1 phosphorylates TP53 (Homo sapiens)
TP53 binds STK11 and NUAK1 (Homo sapiens)
CDK5 phosphorylates TP53 (Homo sapiens)
CDK2 phosphorylates TP53 (Homo sapiens)
TP53 binds HIPK1 (Homo sapiens)
AURKA phosphorylates TP53 (Homo sapiens)
BANP binds TP53 (Homo sapiens)
EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
p-PKR dimer phosphorylates TP53 tetramer (Homo sapiens)
as an output of
TP53 forms homotetramers (Homo sapiens)
USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
as a candidate of
TP63 Tetramer/ TP53 Tetramer [nucleoplasm] (Homo sapiens)
Inferred To
TP53 Tetramer [nucleoplasm]
(Bos taurus)
TP53 Tetramer [nucleoplasm]
(Canis familiaris)
TP53 Tetramer [nucleoplasm]
(Danio rerio)
TP53 Tetramer [nucleoplasm]
(Drosophila melanogaster)
TP53 Tetramer [nucleoplasm]
(Mus musculus)
TP53 Tetramer [nucleoplasm]
(Rattus norvegicus)
TP53 Tetramer [nucleoplasm]
(Sus scrofa)
TP53 Tetramer [nucleoplasm]
(Xenopus tropicalis)
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