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DYRK2 [nucleoplasm]
Stable Identifier
R-HSA-3215037
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
ATM phosphorylates DYRK2 (Homo sapiens)
DYRK2 [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates DYRK2 (Homo sapiens)
DYRK2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92630 DYRK2
Gene Names
DYRK2
Chain
chain:1-601
Reference Genes
BioGPS Gene:8445 DYRK2
COSMIC (genes):DYRK2 DYRK2
CTD Gene:8445 DYRK2
dbSNP Gene:8445 DYRK2
ENSEMBL:ENSG00000127334 DYRK2
ENSEMBL_homo_sapiens_GENE:ENSG00000127334.11 DYRK2
HGNC:3093 DYRK2
KEGG Gene (Homo sapiens):8445 DYRK2
Monarch:8445 DYRK2
NCBI Gene:8445 DYRK2
OMIM:603496 DYRK2
UCSC:Q92630 DYRK2
Reference Transcript
RefSeq:NM_003583.3 DYRK2
RefSeq:NM_006482.2 DYRK2
RefSeq:XM_017020032.1 DYRK2
Other Identifiers
11724611_a_at
11724612_a_at
11724613_a_at
11758911_at
16753751
202968_PM_s_at
202968_s_at
202969_PM_at
202969_at
202970_PM_at
202970_at
202971_PM_s_at
202971_s_at
3420867
3420868
3420869
3420870
3420871
3420872
3420877
3420878
3420879
3420880
3420881
3420882
3420883
3420884
3420886
3420888
3420890
3420892
3420893
40604_at
49632_at
61070_at
73984_r_at
760_at
761_g_at
7956930
8445
85141_at
A_14_P105793
A_14_P139514
A_23_P204048
A_24_P249824
A_24_P56270
A_24_P942786
GE60308
GE763829
GE86715
GO:0000151
GO:0000166
GO:0000287
GO:0003824
GO:0004672
GO:0004674
GO:0004712
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005975
GO:0006091
GO:0006468
GO:0006915
GO:0006974
GO:0007224
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030145
GO:0036211
GO:0042771
GO:0043226
GO:0045725
GO:0070885
GO:0106310
GO:0140096
GO:1901796
GO:1990904
HMNXSV003054175
Hs.173135.1.S1_3p_s_at
Hs.173135.1.S3_3p_at
Hs.173135.1.S4_3p_at
ILMN_1684184
ILMN_1794588
ILMN_2374244
ILMN_2374249
PH_hs_0010380
TC12000597.hg
Y09216_at
g5922003_3p_a_at
Participates
as an input of
MDM2 ubiquitinates DYRK2 (Homo sapiens)
ATM phosphorylates DYRK2 (Homo sapiens)
Other forms of this molecule
PolyUb-DYRK2 [nucleoplasm]
p-T106,S442-DYRK2 [nucleoplasm]
Inferred To
DYRK2 [nucleoplasm]
(Bos taurus)
DYRK2 [nucleoplasm]
(Caenorhabditis elegans)
DYRK2 [nucleoplasm]
(Canis familiaris)
DYRK2 [nucleoplasm]
(Dictyostelium discoideum)
DYRK2 [nucleoplasm]
(Drosophila melanogaster)
DYRK2 [nucleoplasm]
(Gallus gallus)
DYRK2 [nucleoplasm]
(Mus musculus)
DYRK2 [nucleoplasm]
(Rattus norvegicus)
DYRK2 [nucleoplasm]
(Schizosaccharomyces pombe)
DYRK2 [nucleoplasm]
(Sus scrofa)
Homologues of DYRK2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_016875521.1
,
NP_003574.1
,
NP_006473.2
ZINC - World Drugs
DYRK2_HUMAN
Guide to Pharmacology - Targets
2011
OpenTargets
ENSG00000127334
ZINC - FDA approved
DYRK2_HUMAN
ZINC - Substances
DYRK2_HUMAN
ZINC - Biogenic
DYRK2_HUMAN
ZINC target
Q92630
PRO
Q92630
PDB
3KVW
,
7DHN
,
6K0J
,
7DHO
,
7DJO
,
7DHH
,
7DHV
,
5LXC
,
7DL6
,
6HDP
,
7DH9
,
6HDR
,
7DHK
,
8HLT
,
4AZF
,
7AKF
,
7DG4
,
7DH3
,
7DHC
,
3K2L
,
7AKH
,
5LXD
,
5ZTN
ZINC - Investigational
DYRK2_HUMAN
ZINC - Metabolites
DYRK2_HUMAN
IntEnz
2.7.12.1
GeneCards
Q92630
HPA
ENSG00000127334-DYRK2
Ensembl
ENST00000393555
,
ENSP00000342105
,
ENSP00000377186
,
ENST00000344096
,
ENSG00000127334
Pharos - Targets
Q92630
ZINC - Predictions - Purchasable
DYRK2_HUMAN
HMDB Protein
HMDBP01320
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NR20 DYRK4
0.567
3
UniProt:O43379 WDR62
0.556
3
UniProt:Q96C00 ZBTB9
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q9BQD3 KXDL1
0.556
3
UniProt:Q13422 IKZF1
0.556
3
UniProt:P23497 SP100
3
polySUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
monoSUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.556
3
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