Reactome | PIM1 [nucleoplasm]

PIM1 [nucleoplasm]

Stable Identifier

R-HSA-3215094

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/threonine-protein kinase pim-1

Locations in the PathwayBrowser for interactor UniProt:Q96MH2 HEXI2

Expand all

External Reference Information

External Reference

UniProt:P11309 PIM1

Gene Names

PIM1

Chain

chain:1-313

Reference Genes

BioGPS Gene:5292 PIM1

COSMIC (genes):PIM1 PIM1

CTD Gene:5292 PIM1

dbSNP Gene:5292 PIM1

ENSEMBL:ENSG00000137193 PIM1

HGNC:8986 PIM1

KEGG:hsa:5292 PIM1

Monarch:5292 PIM1

NCBI Gene:5292 PIM1

OMIM:164960 PIM1

UCSC:P11309 PIM1

Reference Transcript

Participates

as a member of

STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)

as an output of

STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)

Cross References

Guide to Pharmacology - Targets

2158

OpenTargets

ENSG00000137193

ENSEMBL

ENSG00000137193, ENSP00000362608, ENST00000373509

ZINC - FDA approved

PIM1_HUMAN

ZINC - Substances

PIM1_HUMAN

ZINC - Biogenic

PIM1_HUMAN

ZINC target

P11309

PRO

P11309

GlyGen

P11309

PDB

3QF9, 3MA3, 1XR1, 5N50, 4K0Y, 2O64, 3A99, 3JPV, 4ALU, 5IIS, 3JY0, 6AYD, 6KZI, 6NO8, 5DIA, 3DCV, 3VBV, 8R1P, 6VRV, 5DHJ, 6VRU, 4RC4, 3VBX, 6PDO, 5MZL, 5N4X, 2XIX, 3R01, 5KGD, 4ENX, 5N5L, 6L15, 3CY3, 4BZO, 3T9I, 7OOX, 6L14, 1YXT, 6L11, 3CXW, 6YKD, 4AS0, 4GW8, 4TY1, 4MTA, 5KCX, 2XIY, 3C4E, 3BGZ, 7OOV, 8R1T, 4A7C, 3VBT, 1XQZ, 5N4Z, 4ALV, 5VUC, 4XHK, 5IPJ, 4DTK, 5TOE, 5TEX, 5VUA, 3WE8, 4JX3, 4RPV, 2BZI, 5C1Q, 5KGI, 1YWV, 6PDN, 4N6Y, 3R02, 4K1B, 5KGK, 7XSV, 5N4N, 2O3P, 7QFM, 1XWS, 2BIL, 6L13, 1YXV, 1YXS, 4RBL, 3BWF, 6MT0, 1YHS, 3BGQ, 5EOL, 4MBL, 4LL5, 5N4R, 5NDT, 5DWR, 4I41, 6PDI, 5KGE, 4K18, 3R04, 5N4Y, 3JXW, 5VUB, 2O63, 5TEL, 2J2I, 2XJ1, 3UMW, 5KGG, 3VBY, 4WRS, 2BZH, 5O12, 2OI4, 3VC4, 6PDP, 5N5M, 4N70, 5N4U, 7OOW, 4WSY, 5V82, 5TUR, 2BIK, 3CY2, 4LMU, 8AFR, 1YI4, 4WT6, 4RC2, 4IAA, 3JYA, 2BZK, 6PCW, 2XJ0, 7ZUN, 8R10, 3F2A, 8R1N, 5N4O, 4ALW, 4N6Z, 4MBI, 7VSY, 2O65, 6QXK, 7QB2, 3UMX, 2XIZ, 5N52, 6NO9, 2XJ2, 6BSK, 5O13, 3VBQ, 3VBW, 8R18, 5O11, 7Z6U, 4ENY, 4JX7, 5N51, 5N4V, 3UIX, 6L16, 4BZN, 2OBJ, 5V80, 1YXU, 1YI3, 4LM5, 6L12, 5DGZ, 1YXX, 4RC3, 6L17, 5KZI, 3R00, 2BZJ, 2C3I, 3BGP, 4XH6

ZINC - Investigational

PIM1_HUMAN

ZINC - Metabolites

PIM1_HUMAN

HPA

ENSG00000137193-PIM1

GeneCards

PIM1

Pharos - Targets

P11309

ZINC - Predictions - Purchasable

PIM1_HUMAN

HMDB Protein

HMDBP01271

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.633	7
UniProt:P07954 FH	1	FH [mitochondrial matrix] (R-HSA-70980)	0.556	3
UniProt:Q5T203 Q5T203			0.556	3
UniProt:Q9Y2K1 ZBTB1			0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P0C1Z6-2 TFPT			0.556	3
UniProt:Q96MH2 HEXI2			0.556	3
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:P51116 FXR2			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.527	3
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2

Cite Us!