Reactome | ING2 [nucleoplasm]

ING2 [nucleoplasm]

Stable Identifier

R-HSA-3215167

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, ING1Lp, p32, p33ING2, ING1L

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription cofactors (Homo sapiens)
        
        SUMOylation of ING2 with SUMO1 (Homo sapiens)
        
        ING2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H160 ING2

Gene Names

ING2, ING1L

Chain

chain:1-280

Reference Genes

BioGPS Gene:3622 ING2

COSMIC (genes):ING2 ING2

CTD Gene:3622 ING2

dbSNP Gene:3622 ING2

ENSEMBL:ENSG00000168556 ING2

ENSEMBL_homo_sapiens_GENE:ENSG00000168556.7 ING2

HGNC:6063 ING2

KEGG Gene (Homo sapiens):3622 ING2

Monarch:3622 ING2

NCBI Gene:3622 ING2

OMIM:604215 ING2

UCSC:Q9H160 ING2

Reference Transcript

Other Identifiers

11727091_a_at

11758969_at

16972764

16972770

205981_PM_s_at

205981_s_at

2753954

2753960

2753961

2753962

2753963

2753964

2753965

3622

39555_at

8098508

A_14_P202213

A_21_P0003866

A_23_P83736

GE483109

GE81044

GO:0000122

GO:0000228

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005886

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0007018

GO:0007141

GO:0007165

GO:0007283

GO:0007286

GO:0008289

GO:0012501

GO:0016602

GO:0022414

GO:0023052

GO:0030154

GO:0030317

GO:0030336

GO:0030511

GO:0030512

GO:0035033

GO:0035064

GO:0035091

GO:0042393

GO:0043226

GO:0044877

GO:0045814

GO:0045893

GO:0046872

GO:0048133

GO:0048856

GO:0048870

GO:0060090

GO:0070822

GO:0072520

GO:0098772

GO:0140013

GO:0140566

GO:1902166

GO:1902455

GO:1902459

GO:2000772

GO:2001234

HMNXSV003046945

ILMN_1671265

ILMN_2085722

PH_hs_0027204

TC04000890.hg

TC04002351.hg

g4504694_3p_at

p22618

Participates

as an input of

as a component of

Other forms of this molecule

monoSUMO1-K195-ING2 [nucleoplasm]

Inferred To

ING2 [nucleoplasm] (Bos taurus)

ING2 [nucleoplasm] (Canis familiaris)

ING2 [nucleoplasm] (Danio rerio)

ING2 [nucleoplasm] (Drosophila melanogaster)

ING2 [nucleoplasm] (Gallus gallus)

ING2 [nucleoplasm] (Mus musculus)

ING2 [nucleoplasm] (Rattus norvegicus)

ING2 [nucleoplasm] (Saccharomyces cerevisiae)

ING2 [nucleoplasm] (Schizosaccharomyces pombe)

ING2 [nucleoplasm] (Sus scrofa)

ING2 [nucleoplasm] (Xenopus tropicalis)

Homologues of ING2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of ING2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001278888.1, NP_001555.1

OpenTargets

ENSG00000168556

GeneCards

Q9H160

HPA

ENSG00000168556-ING2

Ensembl

ENSG00000168556, ENST00000302327, ENSP00000307183

PRO

Q9H160

Pharos - Targets

Q9H160

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	6
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.669	4
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.643	4
UniProt:Q9HCE7-2 SMURF1			0.544	3
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.544	3
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:Q9HAJ7 SAP30L	1	SAP30L [nucleoplasm] (R-HSA-351698)	0.527	3
UniProt:Q5PSV4 BRM1L			0.527	3
UniProt:Q01167 FOXK2	1	FOXK2 [nucleoplasm] (R-HSA-5689655)	0.527	3
UniProt:Q9H3R5 CENPH	2	CENPH [nucleoplasm] (R-HSA-606314) CENPH [cytosol] (R-HSA-375294)	0.527	3
UniProt:Q9NP50 SHCAF			0.527	3
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.527	3
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.527	3
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.527	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	4
UniProt:Q9P281 BAHC1			0.527	3
UniProt:Q6ZNC4 ZNF704	1	ZNF704 [nucleoplasm] (R-HSA-2454141)	0.527	2
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.527	3

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