TP53INP1 and HIPK2 bind TP53

Stable Identifier
R-HSA-3215251
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TP53INP1 (p53INP1) forms a complex with TP53 and its regulating kinase HIPK2 (Tomasini et al. 2003, Okamura et al. 2001). HIPK2 undergoes autophosphorylation in response to DNA damage, but the mechanism and the identity of autophosphorylation sites have not yet been fully elucidated (Bitomsky et al. 2013, Saul et al. 2013, Siepi et al. 2013). Autophosphorylation enables HIPK2 binding to PIN1. PIN1 likely facilitates a conformational change that enables HIPK2 to phosphorylate its targets, including TP53 (Bitomsky et al. 2013).

Literature References
PubMed ID Title Journal Year
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity

Tomasini, R, Samir, AA, Carrier, A, Isnardon, D, Cecchinelli, B, Soddu, S, Malissen, B, Dagorn, JC, Iovanna, JL, Dusetti, NJ

J. Biol. Chem. 2003
23485397 HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

Siepi, F, Gatti, V, Camerini, S, Crescenzi, M, Soddu, S

Biochim. Biophys. Acta 2013
11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

Okamura, S, Arakawa, H, Tanaka, T, Nakanishi, H, Ng, CC, Taya, Y, Monden, M, Nakamura, Y

Mol. Cell 2001
23000554 HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

Saul, VV, de la Vega, L, Milanovic, M, Kr├╝ger, M, Braun, T, Fritz-Wolf, K, Becker, K, Schmitz, ML

J Mol Cell Biol 2013
24145406 Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

Bitomsky, N, Conrad, E, Moritz, C, Polonio-Vallon, T, Sombroek, D, Schultheiss, K, Glas, C, Greiner, V, Herbel, C, Mantovani, F, Del Sal, G, Peri, F, Hofmann, TG

Proc. Natl. Acad. Sci. U.S.A. 2013
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