Reactome | USP7 [nucleoplasm]

USP7 [nucleoplasm]

Stable Identifier

R-HSA-3215278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q93009 USP7

Gene Names

USP7, HAUSP

Chain

chain:1-1102

Reference Genes

BioGPS Gene:7874 USP7

COSMIC (genes):USP7 USP7

CTD Gene:7874 USP7

dbSNP Gene:7874 USP7

ENSEMBL:ENSG00000187555 USP7

HGNC:12630 USP7

KEGG Gene (Homo sapiens):7874 USP7

Monarch:7874 USP7

NCBI Gene:7874 USP7

OMIM:602519 USP7

UCSC:Q93009 USP7

Reference Transcript

Other Identifiers

0006180292

11725060_s_at

11725061_a_at

11725062_at

11748350_a_at

11752485_a_at

16823756

201498_at

201499_s_at

222032_s_at

2823081

2823087

2823100

2823102

3679565

3679566

3679567

3679568

3679569

3679570

3679572

3679573

3679574

3679575

3679578

3679580

3679582

3679584

3679586

3679589

3679590

3679591

3679594

3679596

3679597

3679598

3679599

3679600

3679601

3679603

3679606

3679607

3679608

3679609

3679610

3679611

3679612

3679614

3679615

3679620

3679622

3679626

3679627

37672_at

7999326

88975_at

A_23_P49481

A_24_P245108

GE60431

GE86510

GO:0002039

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005975

GO:0006111

GO:0006259

GO:0006281

GO:0006283

GO:0006464

GO:0006508

GO:0006511

GO:0006950

GO:0006974

GO:0007275

GO:0008022

GO:0008134

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0009058

GO:0010216

GO:0016032

GO:0016567

GO:0016579

GO:0016604

GO:0016605

GO:0016787

GO:0019899

GO:0031625

GO:0031647

GO:0032088

GO:0032435

GO:0032991

GO:0034641

GO:0035520

GO:0035616

GO:0036459

GO:0042592

GO:0042752

GO:0043226

GO:0044281

GO:0044403

GO:0048511

GO:0048856

GO:0050821

GO:0051090

GO:0051276

GO:0070536

GO:0071108

GO:0101005

GO:1901537

GO:1904353

GO:1990380

Hs.129663.0.A1_3p_at

Hs.78683.0.S2_3p_at

ILMN_1729319

PH_hs_0024406

PH_hs_0038530

TC16000852.hg

Z72499_at

g4507856_3p_a_at

Participant Of

hasComponent

input

DAXX binds Ub-MDM2 and USP7

output

USP7 deubiquitinates MDM2

Other forms of this molecule

USP7 [cytosol]

Inferred To

Usp7 [nucleoplasm] (Drosophila melanogaster)

Usp7 [nucleoplasm] (Mus musculus)

Usp7 [nucleoplasm] (Rattus norvegicus)

ubp5 [nucleoplasm] (Schizosaccharomyces pombe)

UBP15 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of USP7 [nucleoplasm] (Plasmodium falciparum)

USP7 [nucleoplasm] (Bos taurus)

USP7 [nucleoplasm] (Canis familiaris)

USP7 [nucleoplasm] (Dictyostelium discoideum)

USP7 [nucleoplasm] (Gallus gallus)

USP7 [nucleoplasm] (Sus scrofa)

math-33 [nucleoplasm] (Caenorhabditis elegans)

usp7 [nucleoplasm] (Danio rerio)

usp7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001273386.1, NP_003461.2, NP_001308787.1

OpenTargets

ENSG00000187555

ZINC - Substances

UBP7_HUMAN

ZINC target

Q93009

PRO

Q93009

PDB

3MQR, 5NGE, 4Z97, 4M5W, 5VS6, 5J7T, 2FOJ, 5N9T, 5C6D, 5JTV, 2FOP, 5NGF, 5UQV, 5WHC, 5KYB, 5FWI, 5VSB, 2F1W, 2F1Y, 5C56, 5KYF, 4PYZ, 5KYD, 5UQX, 5VSK, 1NBF, 2XXN, 5JTJ, 4M5X, 3MQS, 4JJQ, 4KG9, 2YLM, 2FOO, 1NB8, 5N9R, 5KYC, 4YOC, 4WPH, 5GG4, 1YZE, 2F1X, 4WPI, 5KYE, 4YSI, 4Z96, 6F5H, 2F1Z, 2KVR, 1YY6

IntEnz

3.4.19.12

GeneCards

Q93009

HPA

ENSG00000187555-USP7

Ensembl

ENST00000381886, ENSP00000343535, ENST00000344836, ENSG00000187555, ENSP00000371310

Orphanet

25027

ZINC - Predictions - Purchasable

UBP7_HUMAN

HMDB Protein

HMDBP10124

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.968	22
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.959	27
UniProt:P03211 EBNA1			0.811	7
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.742	13
UniProt:P08393 ICP0			0.734	4
IntAct:EBI-4399559 UBIQ			0.73	3
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.711	15
UniProt:F5H9D8 F5H9D8			0.702	13
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.688	5
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.669	3
UniProt:Q9UQR0 SCML2			0.669	3
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) SUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.669	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.656	5
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) SUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729) p-S-BMI1 [nucleoplasm] (R-HSA-3229116)	0.646	7
UniProt:O35618	5	phospho-Mdm4 [nucleoplasm] (R-MMU-6804938) Mdm4 [nucleoplasm] (R-MMU-6782502) phospho-Mdm4 [nucleoplasm] (R-MMU-349441) phospho-Mdm4 [nucleoplasm] (R-MMU-349461) Mdm4 [nucleoplasm] (R-MMU-349430)	0.641	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.623	7
UniProt:P60484-1 PTEN			0.602	5
UniProt:Q86VY4 TSYL5			0.591	4
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.591	5
UniProt:P84022 SMAD3	21	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.573	2
UniProt:P06400 RB1	3	p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642) p-RB1 [nucleoplasm] (R-HSA-188389)	0.571	8
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [cytosol] (R-HSA-975983)	0.564	2
UniProt:Q6PIJ6 FBX38			0.564	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.564	2
UniProt:Q96EI5 TCAL4			0.564	3
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.564	2
UniProt:P49915 GMPS	1	GMPS [cytosol] (R-HSA-56085)	0.564	2
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:P36508 ZNF76			0.556	3
UniProt:Q6W2J9 BCOR			0.547	3
UniProt:Q53GL0 PKHO1			0.547	2
UniProt:Q86SQ0 PHLB2			0.547	2
UniProt:P42166 TMPO			0.547	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.547	2
UniProt:P21145 MAL			0.543	3
UniProt:Q99836 MYD88	9	MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [cytosol] (R-HSA-193946) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123)	0.543	3
UniProt:Q9BSM1 PCGF1			0.527	2
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.524	3
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.508	2
UniProt:Q77UV9 Q77UV9			0.499	2
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	2
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.462	3