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USP7 [nucleoplasm]
Stable Identifier
R-HSA-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
DAXX binds Ub-MDM2 and USP7 (Homo sapiens)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates MDM2 (Homo sapiens)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN localization (Homo sapiens)
USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)
USP7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q93009 USP7
Gene Names
USP7, HAUSP
Chain
chain:1-1102
Reference Genes
BioGPS Gene:7874 USP7
COSMIC (genes):USP7 USP7
CTD Gene:7874 USP7
dbSNP Gene:7874 USP7
ENSEMBL:ENSG00000187555 USP7
HGNC:12630 USP7
KEGG Gene (Homo sapiens):7874 USP7
Monarch:7874 USP7
NCBI Gene:7874 USP7
OMIM:602519 USP7
UCSC:Q93009 USP7
Reference Transcript
RefSeq:NM_001286457.1 USP7
RefSeq:NM_001321858.1 USP7
RefSeq:NM_003470.2 USP7
Other Identifiers
0006180292
11725060_s_at
11725061_a_at
11725062_at
11748350_a_at
11752485_a_at
16823756
201498_at
201499_s_at
222032_s_at
2823081
2823087
2823100
2823102
3679565
3679566
3679567
3679568
3679569
3679570
3679572
3679573
3679574
3679575
3679578
3679580
3679582
3679584
3679586
3679589
3679590
3679591
3679594
3679596
3679597
3679598
3679599
3679600
3679601
3679603
3679606
3679607
3679608
3679609
3679610
3679611
3679612
3679614
3679615
3679620
3679622
3679626
3679627
37672_at
7874
7999326
88975_at
A_23_P49481
A_24_P245108
GE60431
GE86510
GO:0002039
GO:0003674
GO:0004197
GO:0004843
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005975
GO:0006111
GO:0006259
GO:0006281
GO:0006283
GO:0006464
GO:0006508
GO:0006511
GO:0006950
GO:0006974
GO:0007275
GO:0008022
GO:0008134
GO:0008150
GO:0008233
GO:0008234
GO:0009056
GO:0009058
GO:0010216
GO:0016032
GO:0016567
GO:0016579
GO:0016604
GO:0016605
GO:0016787
GO:0019899
GO:0031625
GO:0031647
GO:0032088
GO:0032435
GO:0032991
GO:0034641
GO:0035520
GO:0035616
GO:0036459
GO:0042592
GO:0042752
GO:0043226
GO:0044281
GO:0044403
GO:0048511
GO:0048856
GO:0050821
GO:0051090
GO:0051276
GO:0070536
GO:0071108
GO:0101005
GO:1901537
GO:1904353
GO:1990380
Hs.129663.0.A1_3p_at
Hs.78683.0.S2_3p_at
ILMN_1729319
PH_hs_0024406
PH_hs_0038530
TC16000852.hg
Z72499_at
g4507856_3p_a_at
Participant Of
hasComponent
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm]
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm]
UVSSA:USP7 [nucleoplasm]
output
USP7 deubiquitinates MDM2
input
DAXX binds Ub-MDM2 and USP7
Other forms of this molecule
USP7 [cytosol]
Inferred To
Usp7 [nucleoplasm] (Drosophila melanogaster)
Usp7 [nucleoplasm] (Mus musculus)
Usp7 [nucleoplasm] (Rattus norvegicus)
Homologues of USP7 [nucleoplasm] (Schizosaccharomyces pombe)
ubp5 [nucleoplasm] (Schizosaccharomyces pombe)
UBP15 [nucleoplasm] (Saccharomyces cerevisiae)
Ghost homologue of USP7 [nucleoplasm] (Dictyostelium discoideum)
USP7 [nucleoplasm] (Bos taurus)
USP7 [nucleoplasm] (Canis familiaris)
USP7 [nucleoplasm] (Gallus gallus)
USP7 [nucleoplasm] (Sus scrofa)
math-33 [nucleoplasm] (Caenorhabditis elegans)
pitpnb.2 [nucleoplasm] (Xenopus tropicalis)
usp7 [nucleoplasm] (Danio rerio)
ubp21 [nucleoplasm] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_003461.2
,
NP_001308787.1
,
NP_001273386.1
OpenTargets
ENSG00000187555
GeneCards
Q93009
HPA
ENSG00000187555-USP7
ZINC - Substances
UBP7_HUMAN
ZINC target
Q93009
Ensembl
ENSG00000187555
,
ENST00000344836
,
ENST00000381886
,
ENSP00000343535
,
ENSP00000371310
PRO
Q93009
Orphanet
25027
ZINC - Predictions - Purchasable
UBP7_HUMAN
HMDB Protein
HMDBP10124
PDB
4KG9
,
4M5X
,
5KYB
,
6P5L
,
1YY6
,
2F1Z
,
5KYC
,
5C6D
,
3MQS
,
5KYD
,
1NBF
,
2YLM
,
2F1Y
,
6F5H
,
5C56
,
5FWI
,
5UQV
,
4M5W
,
5UQX
,
2XXN
,
2KVR
,
2FOJ
,
6VN3
,
6VN4
,
4WPH
,
4WPI
,
4Z96
,
4Z97
,
6VN5
,
5NGE
,
4JJQ
,
6VN6
,
1YZE
,
5NGF
,
5VS6
,
2F1X
,
5N9R
,
5WHC
,
5JTJ
,
4PYZ
,
5N9T
,
3MQR
,
5KYE
,
2FOP
,
5KYF
,
5J7T
,
2FOO
,
5GG4
,
2F1W
,
5VSB
,
5VSK
,
1NB8
,
6VN2
,
4YOC
,
5JTV
,
4YSI
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.968
22
UniProt:Q00987 MDM2
11
SUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.959
27
UniProt:P03211 EBNA1
0.811
7
UniProt:Q9UER7 DAXX
13
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
SUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.799
14
UniProt:P08393 ICP0
0.734
4
IntAct:EBI-4399559 UBIQ
0.73
3
UniProt:O15151 MDM4
5
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
(R-HSA-6804938)
PolyUb-MDM4 [nucleoplasm]
(R-HSA-6782502)
p-S346,S367,S403-MDM4 [nucleoplasm]
(R-HSA-349441)
p-S403-MDM4 [nucleoplasm]
(R-HSA-349461)
MDM4 [nucleoplasm]
(R-HSA-349430)
0.711
15
UniProt:F5H9D8 F5H9D8
0.702
13
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.688
5
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.669
3
UniProt:Q9UQR0 SCML2
0.669
3
UniProt:P26358 DNMT1
2
DNMT1 [nucleoplasm]
(R-HSA-212181)
SUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
0.669
3
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.656
5
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
SUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
0.646
7
UniProt:O35618
5
phospho-Mdm4 [nucleoplasm]
(R-MMU-6804938)
Mdm4 [nucleoplasm]
(R-MMU-6782502)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349441)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349461)
Mdm4 [nucleoplasm]
(R-MMU-349430)
0.641
4
UniProt:Q9HC52 CBX8
1
CBX8 [nucleoplasm]
(R-HSA-389117)
0.623
7
UniProt:P60484-1 PTEN
0.602
5
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.591
5
UniProt:Q86VY4 TSYL5
0.591
4
UniProt:P84022 SMAD3
21
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.573
2
UniProt:P06400 RB1
394
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
RB1 E209* [cytosol]
(R-HSA-9661776)
RB1 S618* [cytosol]
(R-HSA-9662240)
RB1 S463* [cytosol]
(R-HSA-9662241)
RB1 K720* [cytosol]
(R-HSA-9662269)
RB1 K429* [cytosol]
(R-HSA-9662270)
RB1 K652* [cytosol]
(R-HSA-9662271)
RB1 K715* [cytosol]
(R-HSA-9662264)
RB1 K615* [cytosol]
(R-HSA-9662266)
RB1 K412* [cytosol]
(R-HSA-9662261)
RB1 S567* [cytosol]
(R-HSA-9662218)
RB1 S807* [cytosol]
(R-HSA-9662212)
RB1 R467* [cytosol]
(R-HSA-9662213)
RB1 S834* [cytosol]
(R-HSA-9662210)
RB1 S576* [cytosol]
(R-HSA-9662237)
RB1 S758* [cytosol]
(R-HSA-9662232)
RB1 R7Pfs*24 [cytosol]
(R-HSA-9686292)
RB1 S443* [cytosol]
(R-HSA-9662230)
RB1 S648* [cytosol]
(R-HSA-9662224)
RB1 S391* [cytosol]
(R-HSA-9662225)
RB1 S829* [cytosol]
(R-HSA-9662226)
RB1 D32Tfs*33 [cytosol]
(R-HSA-9688044)
RB1 Y651Ifs*7 [cytosol]
(R-HSA-9688045)
RB1 K143Mfs*19 [cytosol]
(R-HSA-9688046)
RB1 V754Sfs*4 [cytosol]
(R-HSA-9688047)
RB1 L44Rfs*4 [cytosol]
(R-HSA-9688040)
RB1 E97Gfs*13 [cytosol]
(R-HSA-9688041)
RB1 I679* [cytosol]
(R-HSA-9688042)
RB1 W195* [cytosol]
(R-HSA-9689579)
RB1 G100Efs*11 [cytosol]
(R-HSA-9688043)
RB1 S648Tfs*4 [cytosol]
(R-HSA-9688036)
RB1 H281Qfs*6 [cytosol]
(R-HSA-9688037)
RB1 Q384* [cytosol]
(R-HSA-9661925)
RB1 S182Yfs*2 [cytosol]
(R-HSA-9688038)
RB1 L343Sfs*3 [cytosol]
(R-HSA-9688039)
RB1 L337Wfs*12 [cytosol]
(R-HSA-9688032)
RB1 S318* [cytosol]
(R-HSA-9688033)
RB1 N627Mfs*16 [cytosol]
(R-HSA-9688034)
RB1 N290Kfs*20 [cytosol]
(R-HSA-9688035)
RB1 F299Lfs*4 [cytosol]
(R-HSA-9688060)
RB1 Q637* [cytosol]
(R-HSA-9662460)
RB1 L76* [cytosol]
(R-HSA-9688061)
RB1 Q762* [cytosol]
(R-HSA-9662461)
RB1 Y655Lfs*4 [cytosol]
(R-HSA-9688062)
RB1 N480Kfs*13 [cytosol]
(R-HSA-9688063)
RB1 Q444* [cytosol]
(R-HSA-9662463)
RB1 T77Lfs*34 [cytosol]
(R-HSA-9688056)
RB1 E747Gfs*3 [cytosol]
(R-HSA-9688057)
RB1 M825* [cytosol]
(R-HSA-9688058)
RB1 L649Ffs*11 [cytosol]
(R-HSA-9688059)
RB1 N472Ifs*6 [cytosol]
(R-HSA-9688052)
RB1 Y813Kfs*12 [cytosol]
(R-HSA-9688053)
RB1 I324Mfs*17 [cytosol]
(R-HSA-9688054)
RB1 M460Ifs*3 [cytosol]
(R-HSA-9688055)
RB1 Y655Ifs*3 [cytosol]
(R-HSA-9688048)
RB1 L769Cfs*41 [cytosol]
(R-HSA-9688049)
RB1 P28Lfs*37 [cytosol]
(R-HSA-9688050)
RB1 E677Dfs*19 [cytosol]
(R-HSA-9688051)
RB1 P370Lfs*10 [cytosol]
(R-HSA-9688012)
RB1 N593Tfs*11 [cytosol]
(R-HSA-9688013)
RB1 K329* [cytosol]
(R-HSA-9661901)
RB1 S249Ffs*22 [cytosol]
(R-HSA-9688014)
RB1 K240* [cytosol]
(R-HSA-9661902)
RB1 L199Ffs*4 [cytosol]
(R-HSA-9688015)
RB1 P253Gfs*5 [cytosol]
(R-HSA-9688008)
RB1 K289* [cytosol]
(R-HSA-9661896)
RB1 S360Pfs*2 [cytosol]
(R-HSA-9688009)
RB1 E323Kfs*9 [cytosol]
(R-HSA-9688010)
RB1 L326* [cytosol]
(R-HSA-9688011)
RB1 P808Kfs*12 [cytosol]
(R-HSA-9688004)
RB1 D584Nfs*2 [cytosol]
(R-HSA-9688005)
RB1 N406Kfs*4 [cytosol]
(R-HSA-9688006)
RB1 K417Wfs*23 [cytosol]
(R-HSA-9688007)
RB1 L797Ffs*18 [cytosol]
(R-HSA-9688000)
RB1 Q266Hfs*2 [cytosol]
(R-HSA-9688001)
RB1 R255* [cytosol]
(R-HSA-9661889)
RB1 K4* [cytosol]
(R-HSA-9661377)
RB1 P641Afs*12 [cytosol]
(R-HSA-9688002)
RB1 V450Sfs*13 [cytosol]
(R-HSA-9688003)
RB1 K524Rfs*28 [cytosol]
(R-HSA-9688028)
RB1 E280* [cytosol]
(R-HSA-9661916)
RB1 M825Ifs*13 [cytosol]
(R-HSA-9688029)
RB1 M761Nfs*21 [cytosol]
(R-HSA-9688030)
RB1 A11Rfs*20 [cytosol]
(R-HSA-9688031)
RB1 E275* [cytosol]
(R-HSA-9661919)
RB1 A635Gfs*6 [cytosol]
(R-HSA-9688024)
RB1 Q266* [cytosol]
(R-HSA-9661912)
RB1 I66Yfs*11 [cytosol]
(R-HSA-9688025)
RB1 Q257* [cytosol]
(R-HSA-9661913)
RB1 P39Rfs*26 [cytosol]
(R-HSA-9688026)
RB1 T664Nfs*4 [cytosol]
(R-HSA-9688027)
RB1 Y771Lfs*24 [cytosol]
(R-HSA-9688020)
RB1 R320Dfs*12 [cytosol]
(R-HSA-9688021)
RB1 E282* [cytosol]
(R-HSA-9661909)
RB1 L277Pfs*9 [cytosol]
(R-HSA-9688022)
RB1 I124* [cytosol]
(R-HSA-9688023)
RB1 N803Tfs*7 [cytosol]
(R-HSA-9688016)
RB1 M386Ifs*11 [cytosol]
(R-HSA-9688017)
RB1 E72Vfs*34 [cytosol]
(R-HSA-9688018)
RB1 R150Kfs*7 [cytosol]
(R-HSA-9688019)
RB1 L743* [cytosol]
(R-HSA-9687980)
RB1 R7Efs*58 [cytosol]
(R-HSA-9687981)
RB1 T140Nfs*6 [cytosol]
(R-HSA-9687982)
RB1 D479Efs*16 [cytosol]
(R-HSA-9687983)
RB1 L199* [cytosol]
(R-HSA-9661871)
RB1 G801* [cytosol]
(R-HSA-9662377)
RB1 S215* [cytosol]
(R-HSA-9661866)
RB1 G435* [cytosol]
(R-HSA-9662368)
RB1 G581* [cytosol]
(R-HSA-9662369)
RB1 L134* [cytosol]
(R-HSA-9687996)
RB1 Y529Lfs*26 [cytosol]
(R-HSA-9687997)
RB1 S816Qfs*10 [cytosol]
(R-HSA-9687998)
RB1 E693Nfs*3 [cytosol]
(R-HSA-9687999)
RB1 D346Rfs*4 [cytosol]
(R-HSA-9687992)
RB1 Q35* [cytosol]
(R-HSA-9661368)
RB1 I806Lfs*10 [cytosol]
(R-HSA-9687993)
RB1 E54* [cytosol]
(R-HSA-9661369)
RB1 L199Yfs*2 [cytosol]
(R-HSA-9687994)
RB1 E48* [cytosol]
(R-HSA-9661370)
RB1 N854* [cytosol]
(R-HSA-9687995)
RB1 W75* [cytosol]
(R-HSA-9661371)
RB1 L389Ffs*3 [cytosol]
(R-HSA-9687988)
RB1 S230* [cytosol]
(R-HSA-9661876)
RB1 H483Sfs*10 [cytosol]
(R-HSA-9687989)
RB1 S842* [cytosol]
(R-HSA-9687990)
RB1 W78* [cytosol]
(R-HSA-9661366)
RB1 G449Efs*8 [cytosol]
(R-HSA-9687991)
RB1 K63* [cytosol]
(R-HSA-9661367)
RB1 K537Nfs*14 [cytosol]
(R-HSA-9687984)
RB1 L206* [cytosol]
(R-HSA-9661872)
RB1 K63Rfs*38 [cytosol]
(R-HSA-9687985)
RB1 P732Lfs*12 [cytosol]
(R-HSA-9687986)
RB1 L158* [cytosol]
(R-HSA-9661874)
RB1 A562Hfs*49 [cytosol]
(R-HSA-9687987)
RB1 E72* [cytosol]
(R-HSA-9661363)
RB1 G540Afs*3 [cytosol]
(R-HSA-9688172)
RB1 N328Ifs*4 [cytosol]
(R-HSA-9688173)
RB1 E843* [cytosol]
(R-HSA-9662573)
RB1 L385* [cytosol]
(R-HSA-9688174)
RB1 E464* [cytosol]
(R-HSA-9662574)
RB1 N123Tfs*2 [cytosol]
(R-HSA-9688175)
RB1 E112Dfs*6 [cytosol]
(R-HSA-9688168)
RB1 E748* [cytosol]
(R-HSA-9662568)
RB1 M148Ifs*8 [cytosol]
(R-HSA-9688169)
RB1 R661* [cytosol]
(R-HSA-9688170)
RB1 Y453* [cytosol]
(R-HSA-9688164)
RB1 K95* [cytosol]
(R-HSA-9661540)
RB1 M484Vfs*8 [cytosol]
(R-HSA-9688165)
RB1 E533* [cytosol]
(R-HSA-9662565)
RB1 G86* [cytosol]
(R-HSA-9661541)
RB1 V654Sfs*14 [cytosol]
(R-HSA-9688166)
RB1 E747* [cytosol]
(R-HSA-9662566)
RB1 E79* [cytosol]
(R-HSA-9661542)
RB1 C553Wfs*53 [cytosol]
(R-HSA-9688167)
RB1 E677* [cytosol]
(R-HSA-9662567)
RB1 K96* [cytosol]
(R-HSA-9661543)
RB1 C102Yfs*7 [cytosol]
(R-HSA-9688160)
RB1 E737* [cytosol]
(R-HSA-9662560)
RB1 E97* [cytosol]
(R-HSA-9661536)
RB1 R579Qfs*29 [cytosol]
(R-HSA-9688161)
RB1 A525Pfs*7 [cytosol]
(R-HSA-9688162)
RB1 L542Kfs*11 [cytosol]
(R-HSA-9688163)
RB1 F482Sfs*10 [cytosol]
(R-HSA-9688188)
RB1 L797* [cytosol]
(R-HSA-9688189)
RB1 P250Afs*16 [cytosol]
(R-HSA-9688190)
RB1 S194Ffs*7 [cytosol]
(R-HSA-9688191)
RB1 N623Qfs*15 [cytosol]
(R-HSA-9688184)
RB1 T9Rfs*56 [cytosol]
(R-HSA-9688185)
RB1 Y813Qfs*10 [cytosol]
(R-HSA-9688187)
RB1 I768Cfs*23 [cytosol]
(R-HSA-9688180)
RB1 L477Mfs*17 [cytosol]
(R-HSA-9688181)
RB1 E675* [cytosol]
(R-HSA-9662581)
RB1 V654Cfs*4 [cytosol]
(R-HSA-9688182)
RB1 F650Lfs*5 [cytosol]
(R-HSA-9688183)
RB1 P39Sfs*10 [cytosol]
(R-HSA-9688176)
RB1 H281Sfs*2 [cytosol]
(R-HSA-9688177)
RB1 E551* [cytosol]
(R-HSA-9662577)
RB1 C61Vfs*4 [cytosol]
(R-HSA-9688178)
RB1 D145Ifs*8 [cytosol]
(R-HSA-9688179)
RB1 M148Hfs*9 [cytosol]
(R-HSA-9688140)
RB1 E837* [cytosol]
(R-HSA-9662540)
RB1 L158Mfs*19 [cytosol]
(R-HSA-9688141)
RB1 L832Ffs*5 [cytosol]
(R-HSA-9688142)
RB1 E440* [cytosol]
(R-HSA-9662542)
RB1 D224Afs*40 [cytosol]
(R-HSA-9688136)
RB1 P822Qfs*4 [cytosol]
(R-HSA-9688137)
RB1 M148Vfs*8 [cytosol]
(R-HSA-9688138)
RB1 L670Cfs*7 [cytosol]
(R-HSA-9688139)
RB1 E465* [cytosol]
(R-HSA-9662532)
RB1 S414Kfs*14 [cytosol]
(R-HSA-9688133)
RB1 K548Nfs*3 [cytosol]
(R-HSA-9688134)
RB1 L135Tfs*5 [cytosol]
(R-HSA-9688135)
RB1 Q207Tfs*5 [cytosol]
(R-HSA-9688128)
RB1 Q384Tfs*11 [cytosol]
(R-HSA-9688129)
RB1 L797Ffs*14 [cytosol]
(R-HSA-9688130)
RB1 P232Rfs*4 [cytosol]
(R-HSA-9688131)
RB1 T497Hfs*22 [cytosol]
(R-HSA-9688156)
RB1 E817* [cytosol]
(R-HSA-9662556)
RB1 N367* [cytosol]
(R-HSA-9688157)
RB1 L809Rfs*17 [cytosol]
(R-HSA-9688158)
RB1 E693* [cytosol]
(R-HSA-9662558)
RB1 K80* [cytosol]
(R-HSA-9661534)
RB1 W99Lfs*11 [cytosol]
(R-HSA-9688159)
RB1 A15Pfs*3 [cytosol]
(R-HSA-9688152)
RB1 Y239Lfs*25 [cytosol]
(R-HSA-9688153)
RB1 D571Lfs*41 [cytosol]
(R-HSA-9688154)
RB1 N186Ifs*6 [cytosol]
(R-HSA-9688155)
RB1 E837Dfs*12 [cytosol]
(R-HSA-9688148)
RB1 E672* [cytosol]
(R-HSA-9662548)
RB1 H483Yfs*9 [cytosol]
(R-HSA-9688149)
RB1 R775Gfs*35 [cytosol]
(R-HSA-9688150)
RB1 E580* [cytosol]
(R-HSA-9662550)
RB1 G617Rfs*36 [cytosol]
(R-HSA-9688151)
RB1 E492* [cytosol]
(R-HSA-9662551)
RB1 A333Ffs*13 [cytosol]
(R-HSA-9688144)
RB1 L564Sfs*47 [cytosol]
(R-HSA-9688145)
RB1 D156Vfs*19 [cytosol]
(R-HSA-9688147)
RB1 C438Vfs*19 [cytosol]
(R-HSA-9688108)
RB1 C278* [cytosol]
(R-HSA-9688109)
RB1 E209Vfs*3 [cytosol]
(R-HSA-9688110)
RB1 T116Lfs*8 [cytosol]
(R-HSA-9688111)
RB1 R698Afs*22 [cytosol]
(R-HSA-9688104)
RB1 V419* [cytosol]
(R-HSA-9688105)
RB1 I415Nfs*13 [cytosol]
(R-HSA-9688106)
RB1 Y173Ffs*11 [cytosol]
(R-HSA-9688107)
RB1 N133Tfs*3 [cytosol]
(R-HSA-9688100)
RB1 M695Rfs*10 [cytosol]
(R-HSA-9688101)
RB1 R418Sfs*9 [cytosol]
(R-HSA-9688102)
RB1 Q689* [cytosol]
(R-HSA-9662502)
RB1 A74Efs*4 [cytosol]
(R-HSA-9688103)
RB1 W99Yfs*5 [cytosol]
(R-HSA-9688096)
RB1 G442Dfs*15 [cytosol]
(R-HSA-9688097)
RB1 N258Efs*11 [cytosol]
(R-HSA-9688098)
RB1 S182Ifs*3 [cytosol]
(R-HSA-9688099)
RB1 Q436* [cytosol]
(R-HSA-9662499)
RB1 Q395Pfs*11 [cytosol]
(R-HSA-9688124)
RB1 Y606Lfs*47 [cytosol]
(R-HSA-9688125)
RB1 E539* [cytosol]
(R-HSA-9662525)
RB1 L317* [cytosol]
(R-HSA-9688126)
RB1 F104Lfs*7 [cytosol]
(R-HSA-9688127)
RB1 E691* [cytosol]
(R-HSA-9662527)
RB1 D340Yfs*5 [cytosol]
(R-HSA-9688120)
RB1 K740Tfs*10 [cytosol]
(R-HSA-9688121)
RB1 H483Ifs*12 [cytosol]
(R-HSA-9688122)
RB1 R611Lfs*43 [cytosol]
(R-HSA-9688123)
RB1 V291Ifs*9 [cytosol]
(R-HSA-9688116)
RB1 N133* [cytosol]
(R-HSA-9688117)
RB1 R334* [cytosol]
(R-HSA-9688118)
RB1 D697Qfs*23 [cytosol]
(R-HSA-9688119)
RB1 L647Ffs*5 [cytosol]
(R-HSA-9688112)
RB1 I723Nfs*28 [cytosol]
(R-HSA-9688113)
RB1 L486Ifs*6 [cytosol]
(R-HSA-9688114)
RB1 S565* [cytosol]
(R-HSA-9688115)
RB1 Y529Tfs*3 [cytosol]
(R-HSA-9688076)
RB1 Q631* [cytosol]
(R-HSA-9662476)
RB1 S318Nfs*13 [cytosol]
(R-HSA-9688077)
RB1 D856Efs*17 [cytosol]
(R-HSA-9688078)
RB1 P595Lfs*16 [cytosol]
(R-HSA-9688079)
RB1 P777Lfs*33 [cytosol]
(R-HSA-9688072)
RB1 G310Dfs*22 [cytosol]
(R-HSA-9688073)
RB1 P250Sfs*20 [cytosol]
(R-HSA-9688074)
RB1 Q850* [cytosol]
(R-HSA-9662474)
RB1 I124Rfs*6 [cytosol]
(R-HSA-9688075)
RB1 Q702* [cytosol]
(R-HSA-9662475)
RB1 E748Dfs*6 [cytosol]
(R-HSA-9688068)
RB1 Q736* [cytosol]
(R-HSA-9662468)
RB1 R798Qfs*4 [cytosol]
(R-HSA-9688069)
RB1 S588Ffs*6 [cytosol]
(R-HSA-9688070)
RB1 K574* [cytosol]
(R-HSA-9688071)
RB1 D156Mfs*19 [cytosol]
(R-HSA-9688064)
RB1 Y771Cfs*23 [cytosol]
(R-HSA-9688065)
RB1 I66Dfs*44 [cytosol]
(R-HSA-9688066)
RB1 Q685* [cytosol]
(R-HSA-9662466)
RB1 E125Kfs*11 [cytosol]
(R-HSA-9688067)
RB1 Y655Lfs*13 [cytosol]
(R-HSA-9688092)
RB1 R828Kfs*10 [cytosol]
(R-HSA-9688093)
RB1 Y659Ifs*4 [cytosol]
(R-HSA-9688094)
RB1 Q846* [cytosol]
(R-HSA-9662494)
RB1 E97Nfs*14 [cytosol]
(R-HSA-9688095)
RB1 Q770* [cytosol]
(R-HSA-9662495)
RB1 C666* [cytosol]
(R-HSA-9688088)
RB1 Q471* [cytosol]
(R-HSA-9662488)
RB1 R71Efs*39 [cytosol]
(R-HSA-9688089)
RB1 Q504* [cytosol]
(R-HSA-9662489)
RB1 R798Tfs*17 [cytosol]
(R-HSA-9688090)
RB1 Q639* [cytosol]
(R-HSA-9662490)
RB1 N328* [cytosol]
(R-HSA-9688091)
RB1 S576Rfs*34 [cytosol]
(R-HSA-9688084)
RB1 T726Nfs*25 [cytosol]
(R-HSA-9688085)
RB1 Q597* [cytosol]
(R-HSA-9662485)
RB1 I532Nfs*57 [cytosol]
(R-HSA-9688086)
RB1 K577Rfs*34 [cytosol]
(R-HSA-9688087)
RB1 R73Sfs*36 [cytosol]
(R-HSA-9688080)
RB1 E413Kfs*4 [cytosol]
(R-HSA-9688081)
RB1 K844Sfs*5 [cytosol]
(R-HSA-9688082)
RB1 A17Pfs*3 [cytosol]
(R-HSA-9688083)
RB1 Q395* [cytosol]
(R-HSA-9660655)
RB1 L523* [cytosol]
(R-HSA-9662176)
RB1 R251* [cytosol]
(R-HSA-9660640)
RB1 L389* [cytosol]
(R-HSA-9662178)
RB1 Q217* [cytosol]
(R-HSA-9660668)
RB1 Q344* [cytosol]
(R-HSA-9660669)
RB1 S634* [cytosol]
(R-HSA-9662207)
RB1 S565* [cytosol]
(R-HSA-9662200)
RB1 S397* [cytosol]
(R-HSA-9662202)
RB1 S838* [cytosol]
(R-HSA-9662203)
RB1 R556* [cytosol]
(R-HSA-9660661)
RB1 R787* [cytosol]
(R-HSA-9660656)
RB1 G304* [cytosol]
(R-HSA-9662152)
RB1 W516* [cytosol]
(R-HSA-9662660)
RB1 W681* [cytosol]
(R-HSA-9662661)
RB1 E322* [cytosol]
(R-HSA-9662149)
RB1 W563* [cytosol]
(R-HSA-9662656)
RB1 L550* [cytosol]
(R-HSA-9662173)
RB1 R552* [cytosol]
(R-HSA-9660637)
RB1 L512* [cytosol]
(R-HSA-9662168)
RB1 R455* [cytosol]
(R-HSA-9660632)
RB1 R763* [cytosol]
(R-HSA-9662681)
RB1 L779* [cytosol]
(R-HSA-9662169)
RB1 R445* [cytosol]
(R-HSA-9660633)
RB1 R544* [cytosol]
(R-HSA-9662677)
RB1 R320* [cytosol]
(R-HSA-9660630)
RB1 L832* [cytosol]
(R-HSA-9662167)
RB1 Y498* [cytosol]
(R-HSA-9662634)
RB1 Y446* [cytosol]
(R-HSA-9662628)
RB1 Y655* [cytosol]
(R-HSA-9662629)
RB1 E323* [cytosol]
(R-HSA-9662142)
RB1 E364* [cytosol]
(R-HSA-9662143)
RB1 C489* [cytosol]
(R-HSA-9662649)
RB1 G310* [cytosol]
(R-HSA-9662137)
RB1 L335* [cytosol]
(R-HSA-9662139)
RB1 E313* [cytosol]
(R-HSA-9662133)
RB1 E315* [cytosol]
(R-HSA-9662131)
RB1 D479Vfs*14 [cytosol]
(R-HSA-9688204)
RB1 C489Lfs*5 [cytosol]
(R-HSA-9688205)
RB1 Y454* [cytosol]
(R-HSA-9662605)
RB1 E137Rfs*3 [cytosol]
(R-HSA-9688206)
RB1 L676Ffs*16 [cytosol]
(R-HSA-9688207)
RB1 Y728* [cytosol]
(R-HSA-9662607)
RB1 I799Ffs*11 [cytosol]
(R-HSA-9688200)
RB1 D346Vfs*17 [cytosol]
(R-HSA-9688201)
RB1 F514Pfs*8 [cytosol]
(R-HSA-9688202)
RB1 N593Sfs*5 [cytosol]
(R-HSA-9688203)
RB1 T58Yfs*52 [cytosol]
(R-HSA-9688196)
RB1 N522Ifs*2 [cytosol]
(R-HSA-9688197)
RB1 C553Vfs*58 [cytosol]
(R-HSA-9688198)
RB1 P609Cfs*43 [cytosol]
(R-HSA-9688199)
RB1 N269* [cytosol]
(R-HSA-9688192)
RB1 E287Rfs*2 [cytosol]
(R-HSA-9688193)
RB1 E492Lfs*4 [cytosol]
(R-HSA-9688194)
RB1 Q383Nfs*3 [cytosol]
(R-HSA-9688195)
RB1 Y606* [cytosol]
(R-HSA-9662617)
RB1 Y756* [cytosol]
(R-HSA-9662619)
RB1 Y790* [cytosol]
(R-HSA-9662612)
RB1 T502Nfs*17 [cytosol]
(R-HSA-9688208)
RB1 Y709* [cytosol]
(R-HSA-9662608)
RB1 Y749* [cytosol]
(R-HSA-9662611)
RB1 T738_R775del [nucleoplasm]
(R-HSA-9661042)
RB1 [cytosol]
(R-HSA-9660621)
hyperphosphorylated RB1 [nucleoplasm]
(R-HSA-188389)
p-S249-RB1 [nucleoplasm]
(R-HSA-9687343)
p-S230-RB1 [nucleoplasm]
(R-HSA-9687336)
p-T356-RB1 [nucleoplasm]
(R-HSA-9687339)
p-T826-RB1 [nucleoplasm]
(R-HSA-9687334)
p-S252-RB1 [nucleoplasm]
(R-HSA-9687335)
p-S807-RB1 [nucleoplasm]
(R-HSA-9687356)
p-T821-RB1 [nucleoplasm]
(R-HSA-9687357)
p-S795-RB1 [nucleoplasm]
(R-HSA-69226)
p-S612-RB1 [nucleoplasm]
(R-HSA-9687352)
p-S780-RB1 [nucleoplasm]
(R-HSA-9687353)
p-S811-RB1 [nucleoplasm]
(R-HSA-9687354)
RB1 [nucleoplasm]
(R-HSA-68642)
p-S788-RB1 [nucleoplasm]
(R-HSA-9687347)
p-S608-RB1 [nucleoplasm]
(R-HSA-9687351)
p-T373-RB1 [nucleoplasm]
(R-HSA-9687355)
0.571
8
UniProt:Q7Z6Z7 HUWE1
4
HUWE1 [secretory granule lumen]
(R-HSA-6801481)
HUWE1 [cytosol]
(R-HSA-975983)
HUWE1 [extracellular region]
(R-HSA-6806466)
HUWE1 [ficolin-1-rich granule lumen]
(R-HSA-6801467)
0.564
2
UniProt:Q6PIJ6 FBX38
0.564
2
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.564
2
UniProt:Q96EI5 TCAL4
0.564
3
UniProt:Q8WUA2 PPIL4
1
PPIL4 [nucleoplasm]
(R-HSA-8952113)
0.564
2
UniProt:P49915 GMPS
1
GMPS [cytosol]
(R-HSA-56085)
0.564
2
UniProt:Q49AR9 Q49AR9
0.556
3
UniProt:P36508 ZNF76
0.556
3
UniProt:Q6W2J9 BCOR
0.547
3
UniProt:Q53GL0 PKHO1
0.547
2
UniProt:Q86SQ0 PHLB2
0.547
2
UniProt:P42166 TMPO
0.547
2
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.547
2
UniProt:Q99836 MYD88
9
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
MYD88 [cytosol]
(R-HSA-193946)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
0.543
3
UniProt:P21145 MAL
0.543
3
UniProt:Q9BSM1 PCGF1
0.527
2
UniProt:Q5U5Q3 MEX3C
1
MEX3C [cytosol]
(R-HSA-8851640)
0.524
3
UniProt:Q99426 TBCB
1
TBCB [cytosol]
(R-HSA-379546)
0.508
2
UniProt:Q77UV9 Q77UV9
0.499
2
UniProt:P46531 NOTCH1
60
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
p-NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2159809)
p-NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902204)
NOTCH1 L1574P Extracellular Fragment [extracellular region]
(R-HSA-1485582)
NOTCH1 L1600P Extracellular Fragment [extracellular region]
(R-HSA-2681764)
NEXT1 P2474Afs*4 [plasma membrane]
(R-HSA-2902194)
NEXT1 Q2395* [plasma membrane]
(R-HSA-2902192)
NEXT1 Q2440* [plasma membrane]
(R-HSA-2902196)
NEXT1 P2514Rfs*4 [plasma membrane]
(R-HSA-2768989)
NICD1 Q2395* [cytosol]
(R-HSA-2902195)
NICD1 P2514Rfs*4 [cytosol]
(R-HSA-2768996)
NICD1 P2474Afs*4 [cytosol]
(R-HSA-2902193)
NICD1 Q2440* [cytosol]
(R-HSA-2902191)
NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2769013)
NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902208)
NICD1 Q2395* [nucleoplasm]
(R-HSA-2902201)
NICD1 Q2440* [nucleoplasm]
(R-HSA-2902200)
NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2768982)
NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]
(R-HSA-1485596)
NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]
(R-HSA-1485602)
NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2894873)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region]
(R-HSA-2220929)
p-NICD1 [nucleoplasm]
(R-HSA-1604444)
Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911426)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911415)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911503)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane]
(R-HSA-1911511)
Pre-NOTCH1 [endoplasmic reticulum membrane]
(R-HSA-157024)
17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467396)
19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467425)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane]
(R-HSA-1472872)
NOTCH1(1665-2555) [Golgi membrane]
(R-HSA-157092)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane]
(R-HSA-1983679)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane]
(R-HSA-1911512)
NOTCH1(1665-2555) [plasma membrane]
(R-HSA-157239)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]
(R-HSA-1983670)
NOTCH1(1665-1720) [extracellular region]
(R-HSA-157654)
NOTCH1(1721-1753) [plasma membrane]
(R-HSA-157656)
NEXT1 [plasma membrane]
(R-HSA-157200)
NICD1 [cytosol]
(R-HSA-157634)
NICD1 [nucleoplasm]
(R-HSA-157939)
0.462
2
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.462
3
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