Reactome | USP7 [nucleoplasm]

USP7 [nucleoplasm]

Stable Identifier

R-HSA-3215278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q93009 USP7

Gene Names

USP7, HAUSP

Chain

chain:1-1102

Reference Genes

BioGPS Gene:7874 USP7

COSMIC (genes):USP7 USP7

CTD Gene:7874 USP7

dbSNP Gene:7874 USP7

ENSEMBL:ENSG00000187555 USP7

HGNC:12630 USP7

KEGG Gene (Homo sapiens):7874 USP7

Monarch:7874 USP7

NCBI Gene:7874 USP7

OMIM:602519 USP7

UCSC:Q93009 USP7

Reference Transcript

Other Identifiers

0006180292

11725060_s_at

11725061_a_at

11725062_at

11748350_a_at

11752485_a_at

16823756

201498_PM_at

201498_at

201499_PM_s_at

201499_s_at

222032_PM_s_at

222032_s_at

2823081

2823087

2823100

2823102

3679565

3679566

3679567

3679568

3679569

3679570

3679572

3679573

3679574

3679575

3679578

3679580

3679582

3679584

3679586

3679589

3679590

3679591

3679594

3679596

3679597

3679598

3679599

3679600

3679601

3679603

3679606

3679607

3679608

3679609

3679610

3679611

3679612

3679614

3679615

3679620

3679622

3679626

3679627

37672_at

7874

7999326

88975_at

A_23_P49481

A_24_P245108

GE60431

GE86510

GO:0002039

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005975

GO:0006111

GO:0006259

GO:0006281

GO:0006283

GO:0006464

GO:0006508

GO:0006511

GO:0006810

GO:0006950

GO:0006974

GO:0007165

GO:0008022

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0009058

GO:0010216

GO:0016192

GO:0016567

GO:0016579

GO:0016604

GO:0016605

GO:0016787

GO:0019899

GO:0031625

GO:0031647

GO:0032088

GO:0032435

GO:0032991

GO:0034641

GO:0035520

GO:0035616

GO:0042752

GO:0043226

GO:0044281

GO:0048511

GO:0050821

GO:0051090

GO:0051276

GO:0070536

GO:0071108

GO:0101005

GO:1901537

GO:1901796

GO:1904353

GO:1905279

GO:1990380

HMNXSV003020883

Hs.129663.0.A1_3p_at

Hs.78683.0.S2_3p_at

ILMN_1729319

PH_hs_0024406

PH_hs_0038530

TC16000852.hg

Z72499_at

g4507856_3p_a_at

Participates

as a component of

as an output of

USP7 deubiquitinates MDM2 (Homo sapiens)

as an input of

DAXX binds Ub-MDM2 and USP7 (Homo sapiens)

Other forms of this molecule

USP7 [cytosol]

Inferred To

Usp7 [nucleoplasm] (Drosophila melanogaster)

Usp7 [nucleoplasm] (Mus musculus)

Usp7 [nucleoplasm] (Rattus norvegicus)

Homologues of USP7 [nucleoplasm] (Dictyostelium discoideum)

Homologues of USP7 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of USP7 [nucleoplasm] (Schizosaccharomyces pombe)

ubp5 [nucleoplasm] (Schizosaccharomyces pombe)

UBP2 [nucleoplasm] (Saccharomyces cerevisiae)

UBP15 [nucleoplasm] (Saccharomyces cerevisiae)

USP7 [nucleoplasm] (Bos taurus)

USP7 [nucleoplasm] (Canis familiaris)

USP7 [nucleoplasm] (Dictyostelium discoideum)

USP7 [nucleoplasm] (Gallus gallus)

USP7 [nucleoplasm] (Sus scrofa)

math-33 [nucleoplasm] (Caenorhabditis elegans)

usp7 [nucleoplasm] (Danio rerio)

usp7 [nucleoplasm] (Xenopus tropicalis)

ubp21 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001273386.1, NP_003461.2, NP_001308787.1

OpenTargets

ENSG00000187555

ZINC - Substances

UBP7_HUMAN

ZINC target

Q93009

PRO

Q93009

PDB

5UQV, 5KYE, 6VN6, 5N9T, 4PYZ, 5KYF, 5UQX, 1NBF, 5VSB, 4M5W, 7CM2, 2YLM, 5VSK, 6VN2, 3MQR, 3MQS, 1YZE, 6VN3, 5KYB, 6P5L, 2F1X, 6VN4, 5JTV, 4JJQ, 2F1Y, 5KYD, 4Z96, 4WPI, 1NB8, 5C6D, 2F1Z, 5KYC, 5N9R, 5JTJ, 4KG9, 5FWI, 5J7T, 5GG4, 6F5H, 5C56, 6VN5, 4M5X, 2F1W, 6M1K, 4YOC, 2FOJ, 1YY6, 4WPH, 2KVR, 4YSI, 2FOO, 4Z97, 5WHC, 5NGE, 2FOP, 5NGF, 5VS6, 2XXN

IntEnz

3.4.19.12

HPA

ENSG00000187555-USP7

GeneCards

Q93009

Ensembl

ENSG00000187555, ENST00000344836, ENST00000381886, ENSP00000343535, ENSP00000371310

Pharos - Targets

Q93009

ZINC - Predictions - Purchasable

UBP7_HUMAN

Orphanet

25027

HMDB Protein

HMDBP10124

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.968	22
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.965	35
UniProt:P03211 EBNA1			0.811	7
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.799	14
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.785	16
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.739	8
UniProt:P08393 ICP0			0.734	4
IntAct:EBI-4399559 UBIQ			0.73	3
UniProt:F5H9D8 F5H9D8			0.702	13
UniProt:Q53GL0 PKHO1			0.693	3
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.688	5
UniProt:Q9UQR0 SCML2			0.669	3
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.669	3
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.669	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.656	5
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.642	3
UniProt:O35618	5	Mdm4 [nucleoplasm] (R-MMU-6782502) phospho-Mdm4 [nucleoplasm] (R-MMU-6804938) phospho-Mdm4 [nucleoplasm] (R-MMU-349441) phospho-Mdm4 [nucleoplasm] (R-MMU-349461) Mdm4 [nucleoplasm] (R-MMU-349430)	0.641	4
UniProt:P02545 LMNA	3	LMNA(1-664) [nucleoplasm] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.629	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.623	7
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.609	3
UniProt:P52948 NUP98			0.609	2
UniProt:P49750 YLPM1			0.609	2
UniProt:P60484-1 PTEN			0.602	5
UniProt:Q9HCI5 MAGE1			0.592	3
UniProt:Q12816 TROP			0.592	2
UniProt:Q9ULU4 PKCB1			0.592	2
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.591	5
UniProt:Q86VY4 TSYL5			0.591	4
UniProt:O15014 ZN609			0.59	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.59	2
UniProt:Q15007 WTAP	1	WTAP [nucleoplasm] (R-HSA-6789461)	0.59	2
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs25* [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.59	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.59	3
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.59	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.573	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.571	8
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [cytosol] (R-HSA-975983)	0.564	2
UniProt:Q15170 TCAL1			0.564	2
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.564	2
UniProt:Q6PIJ6 FBX38			0.564	2
UniProt:Q96EI5 TCAL4			0.564	3
UniProt:O15355 PPM1G			0.564	2
UniProt:P49915 GMPS	1	GMPS [cytosol] (R-HSA-56085)	0.564	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.564	2
UniProt:P36508 ZNF76			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:Q6W2J9 BCOR			0.547	3
UniProt:Q86SQ0 PHLB2			0.547	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.547	2
UniProt:P42166 TMPO			0.547	2
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.543	3
UniProt:P21145 MAL			0.543	3
UniProt:Q9BSM1 PCGF1			0.527	2
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.524	3
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.508	2
UniProt:Q77UV9 Q77UV9			0.499	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.462	3

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