Reactome | USP7 [nucleoplasm]

USP7 [nucleoplasm]

Stable Identifier

R-HSA-3215278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q93009 USP7

Gene Names

USP7, HAUSP

Chain

chain:1-1102

Reference Genes

BioGPS Gene:7874 USP7

COSMIC (genes):USP7 USP7

CTD Gene:7874 USP7

dbSNP Gene:7874 USP7

ENSEMBL:ENSG00000187555 USP7

ENSEMBL_homo_sapiens_GENE:ENSG00000187555 USP7

HGNC:12630 USP7

KEGG Gene (Homo sapiens):7874 USP7

Monarch:7874 USP7

NCBI Gene:7874 USP7

OMIM:602519 USP7

UCSC:Q93009 USP7

Reference Transcript

Other Identifiers

0006180292

11725060_s_at

11725061_a_at

11725062_at

11748350_a_at

11752485_a_at

15641

16823756

1NB8

1NBF

1YY6

1YZE

201498_at

201499_s_at

222032_s_at

2823081

2823087

2823100

2823102

2F1W

2F1X

2F1Y

2F1Z

2FOJ

2FOO

2FOP

2KVR

2XXN

2YLM

3679565

3679566

3679567

3679568

3679569

3679570

3679572

3679573

3679574

3679575

3679578

3679580

3679582

3679584

3679586

3679589

3679590

3679591

3679594

3679596

3679597

3679598

3679599

3679600

3679601

3679603

3679606

3679607

3679608

3679609

3679610

3679611

3679612

3679614

3679615

3679620

3679622

3679626

3679627

37672_at

3MQR

3MQS

4JJQ

4KG9

4M5W

4M5X

4PYZ

4WPH

4WPI

4YOC

4YSI

4Z96

4Z97

5C56

5C6D

5FWI

5GG4

5J7T

5JTJ

5JTV

5KYB

5KYC

5KYD

5KYE

5KYF

5N9R

5N9T

5NGE

5NGF

5UQV

5UQX

5VS6

5VSB

5VSK

5WHC

6F5H

7874

7999326

8108

88975_at

A_23_P49481

A_24_P245108

AC022167

AK302771

BAH13801

CAA96580

CAB008108

CCDS32385

CCDS66941

CH471112

EAW85194

ENSG00000187555

ENSP00000343535

ENSP00000371310

ENST00000344836

ENST00000344836.8

ENST00000381886

ENST00000381886.8

EntrezGene:7874

F5H2X1

g4507856_3p_a_at

GE60431

GE86510

GO:0002039

GO:0003674

GO:0004197

GO:0004843

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006283

GO:0006464

GO:0006508

GO:0006511

GO:0006950

GO:0006974

GO:0007275

GO:0008022

GO:0008134

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0010216

GO:0016032

GO:0016567

GO:0016579

GO:0016604

GO:0016605

GO:0016787

GO:0019899

GO:0031625

GO:0031647

GO:0032088

GO:0032435

GO:0032991

GO:0034641

GO:0035520

GO:0035616

GO:0036459

GO:0042752

GO:0043226

GO:0044403

GO:0048856

GO:0050821

GO:0051090

GO:0071108

GO:0101005

GO:1901537

GO:1904353

GO:1990380

H3BMF6

H3BND8

H3BQD1

H3BRA2

H3BRI4

H3BTM1

H3BUV0

HGNC:12630

HPA015641

Hs.129663.0.A1_3p_at

Hs.78683.0.S2_3p_at

I3L2D8

ILMN_1729319

IPR001394

IPR002083

IPR008974

IPR018200

IPR024729

IPR028889

IPR029346

IPR038765

MIM:602519

NM_001286457

NM_001286458

NM_001321858

NM_003470

NP_001273386

NP_001273387

NP_001308787

NP_003461

NR_135826

PF00443

PF00917

PF12436

PF14533

PH_hs_0024406

PH_hs_0038530

SM00061

TC16000852.hg

UPI000013F0BE

UPI000059D30E

USP7

USP7-201

USP7-202

XM_017023652

XM_017023653

XP_016879141

XP_016879142

Z72499

Z72499_at

Participant Of

hasComponent

output

USP7 deubiquitinates MDM2

input

DAXX binds Ub-MDM2 and USP7

Other forms of this molecule

USP7 [cytosol]

Inferred To

Ghost homologue of USP7 [nucleoplasm] (Plasmodium falciparum)

USP7 [nucleoplasm] (Bos taurus)

USP7 [nucleoplasm] (Caenorhabditis elegans)

USP7 [nucleoplasm] (Canis familiaris)

USP7 [nucleoplasm] (Danio rerio)

USP7 [nucleoplasm] (Dictyostelium discoideum)

USP7 [nucleoplasm] (Drosophila melanogaster)

USP7 [nucleoplasm] (Gallus gallus)

USP7 [nucleoplasm] (Mus musculus)

USP7 [nucleoplasm] (Rattus norvegicus)

USP7 [nucleoplasm] (Saccharomyces cerevisiae)

USP7 [nucleoplasm] (Schizosaccharomyces pombe)

USP7 [nucleoplasm] (Sus scrofa)

USP7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001308787.1, NP_003461.2

OpenTargets

ENSG00000187555

ZINC - Substances

UBP7_HUMAN

GeneCards

Q93009

ZINC target

Q93009

PRO

Q93009

ZINC - Predictions - Purchasable

UBP7_HUMAN

Orphanet

25027

HMDB Protein

HMDBP10124

PDB

5JTV, 4YSI, 4YOC, 5GG4, 1NBF, 5J7T, 1YY6, 4JJQ, 2F1Z, 5NGE, 5JTJ, 2F1Y, 5NGF, 4PYZ, 5N9R, 3MQR, 5KYE, 5N9T, 4Z97, 2FOO, 5KYF, 2FOP, 4WPI, 4Z96, 4WPH, 2FOJ, 6F5H, 5VSK, 4M5W, 5FWI, 1YZE, 5C56, 5KYC, 2YLM, 5KYD, 3MQS, 5VS6, 5C6D, 2F1X, 5WHC, 2F1W, 5VSB, 2XXN, 5UQV, 1NB8, 5KYB, 5UQX, 4M5X, 4KG9, 2KVR

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.968	22
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.959	27
UniProt:P03211 EBNA1			0.811	7
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.742	13
UniProt:P08393 ICP0			0.734	4
IntAct:EBI-4399559 UBIQ			0.73	3
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.711	15
UniProt:F5H9D8 F5H9D8			0.702	13
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.688	5
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.669	3
UniProt:Q9UQR0 SCML2			0.669	3
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) SUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.669	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.656	5
UniProt:P35226 BMI1	3	p-S-BMI1 [nucleoplasm] (R-HSA-3229116) BMI1 [nucleoplasm] (R-HSA-389121) SUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.646	7
UniProt:O35618	5	phospho-PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-MMU-6804938) PolyUb-MDM4 [nucleoplasm] (R-MMU-6782502) phospho-p-S346,S367,S403-MDM4 [nucleoplasm] (R-MMU-349441) phospho-p-S403-MDM4 [nucleoplasm] (R-MMU-349461) MDM4 [nucleoplasm] (R-MMU-349430)	0.641	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.623	7
UniProt:P60484-1 PTEN			0.602	5
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.591	5
UniProt:Q86VY4 TSYL5			0.591	4
UniProt:P84022 SMAD3	12	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 S425F [cytosol] (R-HSA-8944158) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 S425C [cytosol] (R-HSA-3308499)	0.573	2
UniProt:P06400 RB1	3	p-RB1 [nucleoplasm] (R-HSA-188389) p-S795-RB1 [nucleoplasm] (R-HSA-69226) RB1 [nucleoplasm] (R-HSA-68642)	0.571	8
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [cytosol] (R-HSA-975983)	0.564	2
UniProt:Q6PIJ6 FBX38			0.564	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.564	2
UniProt:Q96EI5 TCAL4			0.564	3
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.564	2
UniProt:P49915 GMPS	1	GMPS [cytosol] (R-HSA-56085)	0.564	2
UniProt:Q6W2J9 BCOR			0.547	3
UniProt:Q86SQ0 PHLB2			0.547	2
UniProt:P42166 TMPO			0.547	2
UniProt:Q99836 MYD88	9	MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-193946) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.543	3
UniProt:P21145 MAL			0.543	3
UniProt:Q9BSM1 PCGF1			0.527	2
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.524	3
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.508	2
UniProt:Q77UV9 Q77UV9			0.499	2
UniProt:Q49AR9 Q49AR9			0.488	2
UniProt:P36508 ZNF76			0.488	2
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [nucleoplasm] (R-HSA-157939) NICD1 [cytosol] (R-HSA-157634)	0.462	2
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537) LMNA(1-664) [nucleoplasm] (R-HSA-535479)	0.462	3