Reactome: A Curated Pathway Database

USP7 deubiquitinates TP53 and counteracts MDM2

Stable Identifier
R-HSA-3215310
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
thiol-dependent ubiquitin-specific protease activity of USP7 [nucleoplasm] USP7 [nucleoplasm] thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events