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USP7 deubiquitinates TP53 and counteracts MDM2

Stable Identifier
R-HSA-3215310
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP7 [nucleoplasm]
Physical Entity
Activity
Orthologous Events