USP7 deubiquitinates TP53 and counteracts MDM2

Stable Identifier
R-HSA-3215310
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).

Literature References
PubMed ID Title Journal Year
11923872 Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Li, M, Chen, D, Shiloh, A, Luo, J, Nikolaev, AY, Qin, J, Gu, W

Nature 2002
16402859 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway

Hu, M, Gu, L, Li, M, Jeffrey, PD, Gu, W, Shi, Y

PLoS Biol. 2006
16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP

Sheng, Y, Saridakis, V, Sarkari, F, Duan, S, Wu, T, Arrowsmith, CH, Frappier, L

Nat. Struct. Mol. Biol. 2006
15053880 A dynamic role of HAUSP in the p53-Mdm2 pathway

Li, M, Brooks, CL, Kon, N, Gu, W

Mol. Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP7 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed