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APOE [endocytic vesicle lumen]
Stable Identifier
R-HSA-3221641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endocytic vesicle lumen
Synonyms
apoE, apolipoprotein E
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class A Receptors (Homo sapiens)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)
MSR1:Ligand [endocytic vesicle membrane] (Homo sapiens)
Ligands of MSR1 [endocytic vesicle lumen] (Homo sapiens)
APOE [endocytic vesicle lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02649 APOE
Gene Names
APOE
Chain
signal peptide:1-18, chain:19-317
Reference Genes
COSMIC (genes):APOE APOE
dbSNP Gene:348 APOE
ENSEMBL:ENSG00000130203 APOE
Participates
as a member of
Ligands of MSR1 [endocytic vesicle lumen] (Homo sapiens)
Other forms of this molecule
APOE [endoplasmic reticulum lumen]
p-APOE [endoplasmic reticulum lumen]
APOE [extracellular region]
APOE-4 [extracellular region]
APOE [plasma membrane]
APOE [clathrin-coated endocytic vesicle membrane]
APOE [endosome membrane]
APOE [endosome lumen]
APOE [early endosome]
Inferred To
APOE [endocytic vesicle lumen]
(Canis familiaris)
APOE [endocytic vesicle lumen]
(Mus musculus)
APOE [endocytic vesicle lumen]
(Rattus norvegicus)
APOE [endocytic vesicle lumen]
(Sus scrofa)
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.809
11
UniProt:Q07954 LRP1
2
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
LRP1 [plasma membrane]
(R-HSA-1454844)
0.784
23
UniProt:P05067-PRO_0000000093 APP
0.75
4
ChEBI:28304 HEPARIN
0.733
8
UniProt:P01130 LDLR
4
LDLR [plasma membrane]
(R-HSA-171053)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
0.71
4
UniProt:P00738 HP
7
HP [specific granule lumen]
(R-HSA-6799622)
HP [extracellular region]
(R-HSA-6799677)
HP [tertiary granule lumen]
(R-HSA-6800879)
7xHC-HP(19-160) [extracellular region]
(R-HSA-2168848)
5xHC-HP(162-406) [extracellular region]
(R-HSA-2168875)
7xHC-HP(19-160) [endocytic vesicle lumen]
(R-HSA-2230994)
5xHC-HP(162-406) [endocytic vesicle lumen]
(R-HSA-2230973)
0.675
7
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.672
8
UniProt:P02649 APOE
10
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [extracellular region]
(R-HSA-174646)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [plasma membrane]
(R-HSA-174615)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [endosome membrane]
(R-HSA-174766)
APOE [endosome lumen]
(R-HSA-174804)
APOE [early endosome]
(R-HSA-2429687)
0.641
9
UniProt:Q9NZC2 TREM2
1
TREM2 [plasma membrane]
(R-HSA-197664)
0.602
4
UniProt:O75069 TMCC2
0.593
5
ChEBI:241349 DIMYRISTOYLPHOSPHATIDYL CHOLINE
0.59
3
UniProt:P21796 VDAC1
7
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
0.589
2
UniProt:P02748 C9
1
C9(22-559) [extracellular region]
(R-HSA-173717)
0.564
2
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.556
3
UniProt:Q9HBG4 ATP6V0A4
2
ATP6V0A4 [phagocytic vesicle membrane]
(R-HSA-1222302)
ATP6V0A4 [endosome membrane]
(R-HSA-912605)
0.556
3
UniProt:P11137-4 MAP2
0.556
3
UniProt:Q06481-5 APLP2
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q9NUB4 CT141
0.556
3
UniProt:Q6PID6 TTC33
0.556
3
UniProt:P10636-6 MAPT
0.556
3
UniProt:Q9Y3D2 MSRB2
1
MSRB2 [cytosol]
(R-HSA-5676906)
0.556
3
UniProt:Q8IUW6 Q8IUW6
0.556
3
IntAct:EBI-25832170 ORF
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:Q14114-3 Q141143
0.556
3
UniProt:Q9NS23-4 RASSF1
0.556
3
UniProt:Q6ZNA4-2 Q6ZNA42
0.556
3
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P02795 MT2A
1
MT2A [cytosol]
(R-HSA-1031707)
0.556
3
UniProt:Q9UIJ7 AK3
1
AK3 [mitochondrial matrix]
(R-HSA-1008241)
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:Q8WTV0-2 SCARB1
2
SCARB1-2 [endocytic vesicle membrane]
(R-HSA-2512788)
SCARB1-2 [plasma membrane]
(R-HSA-349415)
0.556
3
UniProt:Q9H816 DCLRE1B
1
DCLRE1B [nucleoplasm]
(R-HSA-6785735)
0.556
3
UniProt:O75409 HYPM
0.556
3
UniProt:Q8IY40 Q8IY40
0.556
3
IntAct:EBI-25832355 CCSB
0.556
3
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.556
3
UniProt:P17028 ZNF24
0.556
3
UniProt:Q9H6J7-2 CSTPP1
0.556
3
UniProt:Q9NYH9 UTP6
1
UTP6 [nucleoplasm]
(R-HSA-6790674)
0.556
3
UniProt:Q9Y6C2-2 EMILIN1
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:P27958-PRO_0000037570
0.537
4
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.527
7
UniProt:P09238 MMP10
2
MMP10(18-476) [extracellular region]
(R-HSA-1604748)
MMP10 [extracellular region]
(R-HSA-1442488)
0.527
2
UniProt:Q9H8J5 MANS1
0.527
2
UniProt:Q13201 MMRN1
2
MMRN1(20-1228) [extracellular region]
(R-HSA-114635)
MMRN1(20-1228) [platelet alpha granule lumen]
(R-HSA-114634)
0.527
2
UniProt:P20036 HLA-DPA1
9
HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]
(R-HSA-197586)
HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]
(R-HSA-2130639)
HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130435)
HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130485)
HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]
(R-HSA-2130648)
HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130337)
HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]
(R-HSA-2214387)
HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130739)
HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130667)
0.527
2
UniProt:P02655 APOC2
3
APOC2 [early endosome]
(R-HSA-2429686)
APOC2 [cytosol]
(R-HSA-2404145)
APOC2 [extracellular region]
(R-HSA-174699)
0.527
2
UniProt:P08254 MMP3
6
MMP3(100-477) [extracellular region]
(R-HSA-1430778)
MMP3 [extracellular region]
(R-HSA-8943665)
MMP3(18-477) [extracellular region]
(R-HSA-1604707)
MMP3(55-477) [extracellular region]
(R-HSA-1604735)
MMP3(18-54) [extracellular region]
(R-HSA-1604705)
MMP3(55-99) [extracellular region]
(R-HSA-1604687)
0.527
2
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.524
4
UniProt:Q9UBD9 CLCF1
1
CLCF1 [extracellular region]
(R-HSA-5693175)
0.524
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.482
3
UniProt:P50502 ST13
1
ST13 [cytosol]
(R-HSA-5255410)
0.482
3
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.482
3
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