Reactome | HSP90B1 [extracellular region]

HSP90B1 [extracellular region]

Stable Identifier

R-HSA-3221653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Endoplasmin, ENPL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14625 HSP90B1

Gene Names

HSP90B1, GPR94, GRP94, TRA1

Chain

signal peptide:1-21, chain:22-803

Reference Genes

BioGPS Gene:7184 HSP90B1

COSMIC (genes):HSP90B1 HSP90B1

CTD Gene:7184 HSP90B1

dbSNP Gene:7184 HSP90B1

ENSEMBL:ENSG00000166598 HSP90B1

HGNC:12028 HSP90B1

KEGG:hsa:7184 HSP90B1

Monarch:7184 HSP90B1

NCBI Gene:7184 HSP90B1

OMIM:191175 HSP90B1

UCSC:P14625 HSP90B1

Reference Transcript

RefSeq:NM_003299.2 HSP90B1

Other Identifiers

11741912_a_at

11741913_s_at

11752967_x_at

11753260_x_at

11754606_a_at

11754607_s_at

11754608_x_at

16756078

200598_PM_s_at

200598_s_at

200599_PM_s_at

200599_s_at

216449_3p_x_at

216449_PM_x_at

216449_x_at

2346499

2346503

239451_PM_at

239451_at

3429311

3429313

3429314

3429316

3429317

3429318

3429319

3429320

3429321

3429322

3429323

3429324

3429325

3429326

3429327

3429328

3429329

3429330

3429331

3429332

3429333

3429334

3429335

3429336

3429337

3429338

3429339

3429340

3429341

3429342

3429343

3429344

3429345

3429346

3429347

3429348

3429349

3429350

3429351

3429352

3429356

3429357

3429358

3429360

3611056

3611061

3611062

3611065

3611071

442_at

68624_at

7184

7958130

A_14_P120291

A_23_P2601

A_24_P150361

GE79080

GO:0001666

GO:0003723

GO:0003824

GO:0005509

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005783

GO:0005788

GO:0005789

GO:0005790

GO:0005829

GO:0005886

GO:0005925

GO:0006457

GO:0006886

GO:0015031

GO:0016020

GO:0016529

GO:0016787

GO:0016887

GO:0019903

GO:0030163

GO:0030312

GO:0030496

GO:0030970

GO:0031012

GO:0031247

GO:0031410

GO:0032991

GO:0033018

GO:0034663

GO:0034975

GO:0034976

GO:0036503

GO:0042470

GO:0043066

GO:0043226

GO:0043666

GO:0044183

GO:0048471

GO:0050750

GO:0051082

GO:0051208

GO:0062023

GO:0070062

GO:0071287

GO:0071318

GO:0071682

GO:0097524

GO:0140657

GO:0140662

HMNXSV003014483

HMNXSV003050728

Hs.192374.0.S1_3p_at

Hs.288528.0.S1_3p_s_at

Hs.82689.0.S1_3p_a_at

ILMN_2096116

PH_hs_0022928

TC12000803.hg

X15187_at

g4507676_3p_a_at

Participates

as a member of

Ligands of MSR1 [extracellular region] (Homo sapiens)

Other forms of this molecule

HSP90B1 [endocytic vesicle lumen]

p-HSP90B1 [endoplasmic reticulum lumen]

HSP90B1 [endoplasmic reticulum lumen]

Inferred To

HSP90B1 [extracellular region] (Canis familiaris)

HSP90B1 [extracellular region] (Gallus gallus)

HSP90B1 [extracellular region] (Mus musculus)

HSP90B1 [extracellular region] (Rattus norvegicus)

HSP90B1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_003290.1

Guide to Pharmacology - Targets

2904

ENSEMBL

ENST00000299767, ENSP00000299767

OpenTargets

ENSG00000166598

ZINC - Substances

ENPL_HUMAN

ZINC target

P14625

PRO

P14625

GlyGen

P14625

PDB

4NH9, 7ULL

ZINC - Investigational

ENPL_HUMAN

HPA

ENSG00000166598-HSP90B1

Pharos - Targets

P14625

ZINC - Predictions - Purchasable

ENPL_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.643	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.623	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:Q00597 FANCC	2	FANCC [cytosol] (R-HSA-420801) FANCC [nucleoplasm] (R-HSA-419530)	0.581	4
ChEBI:28304 HEPARIN			0.564	4
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.564	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2

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