Reactome | HYOU1 [endocytic vesicle lumen]

HYOU1 [endocytic vesicle lumen]

Stable Identifier

R-HSA-3221924

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle lumen

Synonyms

Hypoxia up-regulated protein 1, HYOU1_HUMAN, GRP170

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class F Receptors (Homo sapiens)
    - SCARF1:ligand is endocytosed (Homo sapiens)
      - SCARF1:Ligand [endocytic vesicle membrane] (Homo sapiens)
        
        Ligands of SCARF1 [endocytic vesicle lumen] (Homo sapiens)
        
        HYOU1 [endocytic vesicle lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y4L1 HYOU1

Gene Names

HYOU1, GRP170, ORP150

Chain

signal peptide:1-32, chain:33-999

Reference Genes

BioGPS Gene:10525 HYOU1

COSMIC (genes):HYOU1 HYOU1

CTD Gene:10525 HYOU1

dbSNP Gene:10525 HYOU1

ENSEMBL:ENSG00000149428 HYOU1

ENSEMBL:ENSG00000280682 HYOU1

HGNC:16931 HYOU1

KEGG Gene (Homo sapiens):10525 HYOU1

Monarch:10525 HYOU1

NCBI Gene:10525 HYOU1

OMIM:601746 HYOU1

UCSC:Q9Y4L1 HYOU1

Reference Transcript

Other Identifiers

0004730048

10525

11716005_a_at

11716006_a_at

11748624_a_at

11748625_x_at

11749688_a_at

11749689_x_at

11750616_a_at

11752033_x_at

11756961_a_at

16745186

200825_s_at

33863_at

3394124

3394125

3394126

3394127

3394128

3394129

3394130

3394131

3394132

3394133

3394135

3394138

3394140

3394142

3394143

3394144

3394145

3394146

3394147

3394149

3394150

3394151

3394152

3394153

3394154

3394155

3394159

3394160

3394161

3394162

3394164

3394165

3394167

3394168

3394169

3394172

3394173

3394174

7952145

A_23_P75647

GE59322

GO:0000166

GO:0000774

GO:0002931

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005790

GO:0005925

GO:0006810

GO:0006888

GO:0006898

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0016020

GO:0016192

GO:0030234

GO:0031410

GO:0032991

GO:0034663

GO:0034976

GO:0036498

GO:0043167

GO:0043226

GO:0050790

GO:0051082

GO:0051087

GO:0070062

GO:0071456

GO:0071682

GO:1903298

HMNXSV003013820

ILMN_1673649

ILMN_2141790

PH_hs_0014249

TC11002361.hg

U65785_at

g13699861_3p_a_at

Participates

as a member of

Ligands of SCARF1 [endocytic vesicle lumen] (Homo sapiens)

Other forms of this molecule

HYOU1 [endoplasmic reticulum lumen]

HYOU1 [extracellular region]

Cross References

RefSeq

XP_016872586.1, XP_016872585.1, NP_006380.1, NP_001124463.1

OpenTargets

ENSG00000149428

GeneCards

Q9Y4L1

HPA

ENSG00000149428-HYOU1

Ensembl

ENSG00000280682, ENSP00000486825, ENST00000630669, ENST00000617285, ENSP00000480150, ENSG00000149428

PRO

Q9Y4L1

Orphanet

28515

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11021 HSPA5	6	HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.564	2
UniProt:P02452 COL1A1	129	3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441) Dehydrolysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396169) Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396104) Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396303) Dehydrolysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396380) Dehydrolysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396242) Dehydrolysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396258) Dehydrolysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396112) Dehydrolysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396455) Dehydrolysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396214) Dehydrolysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396310) Hydroxylysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396396) Hydroxylysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396247) Hydroxylysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396452) Lysino-5-ketonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396297) Lysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396479) Lysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396336) 3x4Hyp-3Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228701) Alys-COL1A1 [extracellular region] (R-HSA-2228703) 3x4Hyp-Alys-COL1A1 [extracellular region] (R-HSA-2228686) Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228697) 3x4Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228712) 3x4Hyp-3Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228696) 3x4Hyp-5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228709) 3x4Hyp-3Hyp-Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228692) Alys-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2228695) 3x4Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228710) 5Hyl-Alys-COL1A1 [extracellular region] (R-HSA-2228706) 3x4Hyp-3Hyp-Alys-GalHyl-COL1A1 [extracellular region] (R-HSA-2228690) Dehydrohydroxylysinonorlysyl Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396090) Dehydrohydroxylysinonorlysyl 3,4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396138) Dehydrohydroxylysinonorlysyl 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396266) Dehydrohydroxylysinonorlysyl 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396072) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396344) Dehydrohydroxylysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396066) Dehydrohydroxylysinonorlysyl 5-hydroxylysl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396434) Dehydrohydroxylysinonorlysyl Collagen alpha-1(I) chain [extracellular region] (R-HSA-2396065) Dehydrohydroxylysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396369) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396023) Dehydrohydroxylysinonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396215) Dehydrohydroxylysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396278) Hydroxylysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396043) Hydroxylysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396302) Hydroxylysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396050) Hydroxylysino-5-ketonorlysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396211) Hydroxylysino-5-ketonorlysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396305) Hydroxylysino-5-ketonorlysyl 5-hydroxylysyl-collagen alpha-1(I) chain [extracellular region] (R-HSA-2396196) Hydroxyallysyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396424) Hydroxyallysyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396384) Hydroxyallysyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396309) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268636) GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268623) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268639) GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268649) 3x4Hyp-GalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268681) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268648) COL1A1(23-1464) [extracellular region] (R-HSA-2268635) 3x4Hyp-3Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268634) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268656) 5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268624) 3x4Hyp-5Hyl-COL1A1(23-1464) [extracellular region] (R-HSA-2268643) 3x4Hyp-COL1A1(23-1464) [extracellular region] (R-HSA-2268642) 3x4Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268813) 3x4Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268893) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268892) 3x4Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268815) 5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268895) GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268807) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268743) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268935) GalHyl-COL1A1(162-1464) [extracellular region] (R-HSA-2268742) 3x4Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268913) COL1A1(162-1464) [extracellular region] (R-HSA-2268848) 3x4Hyp-3Hyp-COL1A1(162-1464) [extracellular region] (R-HSA-2268739) 3x4Hyp-3Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467162) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467131) GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467128) COL1A1(954-1218) [extracellular region] (R-HSA-2467160) 3x4Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467129) 3x4Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467134) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467167) 3x4Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467165) 3x4Hyp-3Hyp-GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467154) 3x4Hyp-GlcGalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467155) 3x4Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467153) 3x4Hyp-3Hyp-5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467159) 3x4Hyp-3Hyp-GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467157) GalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467178) 3x4Hyp-3Hyp-5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467179) 5Hyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467144) 3x4Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467151) 3x4Hyp-GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467180) GalHyl-COL1A1(162-953) [extracellular region] (R-HSA-2467149) GlcGalHyl-COL1A1(954-1218) [extracellular region] (R-HSA-2467168) COL1A1(162-953) [extracellular region] (R-HSA-2467136) 3x4Hyp-COL1A1(954-1218) [extracellular region] (R-HSA-2467137) 3x4Hyp-3Hyp-COL1A1(162-953) [extracellular region] (R-HSA-2467174) 5Hyl-COL1A1(162-953) [extracellular region] (R-HSA-2467172) 3x4Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089968) GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089969) 3x4Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089985) GalHyl-COL1A1 [extracellular region] (R-HSA-2089982) 3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region] (R-HSA-2089980) 3x4Hyp-3Hyp-GlcGalHyl-COL1A1 [extracellular region] (R-HSA-2089979) COL1A1 [extracellular region] (R-HSA-51125) 3x4Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089992) 5Hyl-COL1A1 [extracellular region] (R-HSA-2089974) 3x4Hyp-3Hyp-COL1A1 [extracellular region] (R-HSA-2089989) 3x4Hyp-COL1A1 [extracellular region] (R-HSA-2089988) 3x4Hyp-3Hyp-5Hyl-COL1A1 [extracellular region] (R-HSA-2089986)	0.558	3
UniProt:P0DTC8 NS8			0.527	2

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