Reactome | p-T211-NUAK1 [nucleoplasm]

p-T211-NUAK1 [nucleoplasm]

Stable Identifier

R-HSA-3222011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q93008 USP9X

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        NUAK1 phosphorylates TP53 (Homo sapiens)
        
        p-T211-NUAK1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60285 NUAK1

Gene Names

NUAK1, ARK5, KIAA0537, OMPHK1

Chain

chain:1-661

Reference Genes

BioGPS Gene:9891 NUAK1

COSMIC (genes):NUAK1 NUAK1

CTD Gene:9891 NUAK1

dbSNP Gene:9891 NUAK1

ENSEMBL:ENSG00000074590 NUAK1

HGNC:14311 NUAK1

KEGG:hsa:9891 NUAK1

Monarch:9891 NUAK1

NCBI Gene:9891 NUAK1

OMIM:608130 NUAK1

UCSC:O60285 NUAK1

Reference Transcript

RefSeq:NM_014840.3 NUAK1

Other Identifiers

11739971_at

11739972_at

11739973_s_at

16769569

204589_PM_at

204589_at

33787_at

3469598

3469599

3469600

3469601

3469602

3469603

3469606

3469607

3469615

3469616

3469617

3469618

3469620

3469633

3469649

7966026

9891

A_23_P348257

A_33_P3371889

GE62233

GO:0001650

GO:0002039

GO:0003824

GO:0004672

GO:0004674

GO:0004676

GO:0004677

GO:0004679

GO:0004694

GO:0004711

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005856

GO:0006325

GO:0006338

GO:0006468

GO:0006974

GO:0007155

GO:0015630

GO:0016740

GO:0030155

GO:0035175

GO:0035402

GO:0035403

GO:0035979

GO:0042127

GO:0043226

GO:0044022

GO:0044023

GO:0044024

GO:0044025

GO:0046872

GO:0072354

GO:0072371

GO:0072518

GO:0106310

GO:0140096

GO:0140823

GO:0140855

GO:0140857

GO:1901796

GO:1990244

GO:2000772

HMNXSV003027163

ILMN_1689318

ILMN_2079786

PH_hs_0032140

TC12001916.hg

g7662169_3p_at

Participates

as an output of

NUAK1 phosphorylates TP53 (Homo sapiens)

as a component of

TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NUAK1 [nucleoplasm]

Inferred To

phospho-Nuak1 [nucleoplasm] (Mus musculus)

phospho-Nuak1 [nucleoplasm] (Rattus norvegicus)

phospho-NUAK1 [nucleoplasm] (Bos taurus)

phospho-NUAK1 [nucleoplasm] (Canis familiaris)

phospho-NUAK1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-threonine at 211

Coordinate

211

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_055655.1

ZINC - World Drugs

NUAK1_HUMAN

Guide to Pharmacology - Targets

2129

ENSEMBL

ENSP00000261402, ENSG00000074590, ENST00000261402

OpenTargets

ENSG00000074590

ZINC - FDA approved

NUAK1_HUMAN

ZINC - Substances

NUAK1_HUMAN

ZINC - Biogenic

NUAK1_HUMAN

ZINC target

O60285

PRO

O60285

ZINC - Investigational

NUAK1_HUMAN

ZINC - Metabolites

NUAK1_HUMAN

GeneCards

NUAK1

HPA

ENSG00000074590-NUAK1

Pharos - Targets

O60285

ZINC - Predictions - Purchasable

NUAK1_HUMAN

HMDB Protein

HMDBP01269

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UKB1 FBXW11	2	FBXW11 [cytosol] (R-HSA-976035) FBXW11 [nucleoplasm] (R-HSA-9953055)	0.643	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.591	5
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.564	2
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.564	2
UniProt:P10644 PRKAR1A	4	PRKAR1A [cytosol] (R-HSA-57836) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476)	0.564	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.527	2