NUAK1 phosphorylates TP53

Stable Identifier
R-HSA-3222020
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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NUAK1 phosphorylates TP53
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NUAK1, activated by STK11 (LKB1)-mediated phosphorylation on threonine residue T211, phosphorylates TP53 (p53) on serine residues S15 and S392, contributing to TP53-mediated transcriptional activation of the CDKN1A (p21) gene (Zeng and Berger 2006, Hou et al. 2011).

Literature References
PubMed ID Title Journal Year
21317932 A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation

Hou, X, Liu, JE, Liu, W, Liu, CY, Liu, ZY, Sun, ZY

Oncogene 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
Physical Entity
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
NUAK1 phosphorylates TP53 (Bos taurus)
NUAK1 phosphorylates TP53 (Mus musculus)
NUAK1 phosphorylates TP53 (Rattus norvegicus)
NUAK1 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)
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