Reactome: A Curated Pathway Database

DAXX binds Ub-MDM2 and USP7

Stable Identifier
R-HSA-3222072
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DAXX paired amphipathic helix domain 2 (PAH2) binds MDM2, while DAXX PAH1 domain and acid rich region simultaneously bind USP7 (HAUSP) (Tang et al. 2006), forming a tripartite complex.

Literature References
PubMed ID Title Journal Year
16845383 Critical role for Daxx in regulating Mdm2 Nat. Cell Biol. 2006
Participants
Participant Of
Orthologous Events