Reactome | BRD7 [nucleoplasm]

BRD7 [nucleoplasm]

Stable Identifier

R-HSA-3222092

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bromodomain-containing protein 7, 75 kDa bromodomain protein, Protein CELTIX-1, BP75, CELTIX1

Locations in the PathwayBrowser for interactor UniProt:Q12824

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        BRD7 binds TP53 and EP300 (Homo sapiens)
        
        BRD7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPI1 BRD7

Gene Names

BRD7, BP75, CELTIX1

Chain

chain:1-651

Reference Genes

BioGPS Gene:29117 BRD7

COSMIC (genes):BRD7 BRD7

CTD Gene:29117 BRD7

dbSNP Gene:29117 BRD7

ENSEMBL:ENSG00000166164 BRD7

ENSEMBL_homo_sapiens_GENE:ENSG00000166164.17 BRD7

HGNC:14310 BRD7

KEGG Gene (Homo sapiens):29117 BRD7

Monarch:29117 BRD7

NCBI Gene:29117 BRD7

OMIM:618489 BRD7

UCSC:Q9NPI1 BRD7

Reference Transcript

Other Identifiers

11756939_s_at

16826414

221776_PM_s_at

221776_s_at

222737_PM_s_at

222737_s_at

228289_PM_at

228289_at

238545_PM_at

238545_at

2650116

2650117

2650120

2650121

2650122

2650123

2650125

2650127

2650129

2650133

2650135

2650137

2650139

29117

2921558

2921564

2921566

2921572

3521107

3521108

3521112

3521114

3691072

3691073

3691074

3691075

3691076

3691077

3691078

3691079

3691080

3691081

3691082

3691084

3691085

3691086

3691087

3691088

3691089

3691090

3691091

3691092

3691093

3691096

3691099

3691100

3691101

3691105

3691108

3691112

3691113

3691116

3691117

3691118

3691119

48361_at

63521_at

8001350

91003_at

GE81811

GO:0000278

GO:0000776

GO:0000785

GO:0000976

GO:0002039

GO:0002376

GO:0003677

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006281

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007049

GO:0007059

GO:0007155

GO:0007346

GO:0016055

GO:0016363

GO:0016586

GO:0023052

GO:0030071

GO:0030154

GO:0042393

GO:0043226

GO:0045582

GO:0045597

GO:0045663

GO:0045815

GO:0045892

GO:0045893

GO:0048856

GO:0070316

GO:0070577

GO:0140110

GO:2000045

GO:2000134

GO:2000781

GO:2000819

HMNXSV003048495

Hs.172199.1.A1_3p_at

Hs.172199.1.A1_3p_s_at

Hs.279762.0.A1_3p_a_at

Hs.279762.1.S1_3p_a_at

Hs.92888.0.A1_3p_at

ILMN_1696420

ILMN_2082810

PH_hs_0025644

TC16001104.hg

Participates

as an input of

BRD7 binds TP53 and EP300 (Homo sapiens)

as a component of

Inferred To

Brd7 [nucleoplasm] (Mus musculus)

Brd7 [nucleoplasm] (Rattus norvegicus)

brd7 [nucleoplasm] (Xenopus tropicalis)

Brd7-9 [nucleoplasm] (Drosophila melanogaster)

BRD7 [nucleoplasm] (Bos taurus)

BRD7 [nucleoplasm] (Canis familiaris)

BRD7 [nucleoplasm] (Dictyostelium discoideum)

BRD7 [nucleoplasm] (Gallus gallus)

BRD7 [nucleoplasm] (Plasmodium falciparum)

BRD7 [nucleoplasm] (Sus scrofa)

swsn-9 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001167455.1, NP_037395.2

Guide to Pharmacology - Targets

2726

OpenTargets

ENSG00000166164

ZINC - Substances

BRD7_HUMAN

HPA

ENSG00000166164-BRD7

GeneCards

Q9NPI1

ZINC target

Q9NPI1

Ensembl

ENSP00000378181, ENSP00000378180, ENSG00000166164, ENST00000394689, ENST00000394688

PRO

Q9NPI1

Pharos - Targets

Q9NPI1

PDB

6V0Q, 6V1E, 6V17, 7VDV, 7Y8R, 6V1H, 5MQ1, 6V16, 6V1F, 6PPA, 2I7K

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.745	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.729	9
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.616	5
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.591	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.536	2

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