Reactome | L3MBTL1 [nucleoplasm]

L3MBTL1 [nucleoplasm]

Stable Identifier

R-HSA-3222110

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Lethal(3)malignant brain tumor-like protein 1, L(3)mbt protein homolog, L3MBT, L3MBTL, KIAA0681

Locations in the PathwayBrowser for interactor UniProt:P62805%20H4C1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)
        
        L3MBTL1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y468 L3MBTL1

Gene Names

L3MBTL1, KIAA0681, L3MBT, L3MBTL

Chain

chain:1-840

Reference Genes

BioGPS Gene:26013 L3MBTL1

COSMIC (genes):L3MBTL1 L3MBTL1

CTD Gene:26013 L3MBTL1

dbSNP Gene:26013 L3MBTL1

ENSEMBL:ENSG00000185513 L3MBTL1

ENSEMBL_homo_sapiens_GENE:ENSG00000185513.18 L3MBTL1

HGNC:15905 L3MBTL1

KEGG Gene (Homo sapiens):26013 L3MBTL1

Monarch:26013 L3MBTL1

NCBI Gene:26013 L3MBTL1

OMIM:608802 L3MBTL1

UCSC:Q9Y468 L3MBTL1

Reference Transcript

Other Identifiers

11733566_a_at

11733567_a_at

16913869

206822_PM_s_at

206822_s_at

210306_PM_at

210306_at

213837_PM_at

213837_at

216077_PM_s_at

216077_s_at

26013

34242_at

34243_i_at

34244_r_at

3886046

3886073

3886076

3886077

3886078

3886079

3886080

3886081

3886082

3886083

3886084

3886085

3886090

3886091

3886093

3886094

3886095

3886097

3886101

3886102

3886103

3886104

3886105

3886107

3886111

3886112

3886113

3886114

3886116

3886118

3886119

3886121

3886122

3886123

3886124

3886125

3886126

3886127

3886128

8062705

ADDON000593.hg

ADDON002083.hg

A_19_P00316105

A_19_P00316107

A_23_P210445

A_23_P501961

GE53388

GE538295

GO:0000278

GO:0000785

GO:0000793

GO:0002376

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006351

GO:0006355

GO:0007088

GO:0008270

GO:0030097

GO:0030154

GO:0031491

GO:0031507

GO:0032093

GO:0035064

GO:0042393

GO:0042802

GO:0043226

GO:0045652

GO:0045892

GO:0046872

GO:0048856

GO:0051726

GO:0061793

GO:0140014

HMNXSV003053488

HMNXSV003057550

Hs.278516.1.S1_3p_at

Hs.300863.1.S1_3p_a_at

ILMN_1658277

ILMN_1774258

ILMN_2400940

PH_hs_0015489

PH_hs_0038647

TC20001723.hg

g3811110_3p_at

g7661701_3p_s_at

Participates

as a component of

L3MBTL1:Me-K382,p-S-15,S20-TP53 [nucleoplasm] (Homo sapiens)

as an input of

L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)

Inferred To

L3MBTL1 [nucleoplasm] (Bos taurus)

L3MBTL1 [nucleoplasm] (Canis familiaris)

L3MBTL1 [nucleoplasm] (Gallus gallus)

L3MBTL1 [nucleoplasm] (Mus musculus)

L3MBTL1 [nucleoplasm] (Rattus norvegicus)

L3MBTL1 [nucleoplasm] (Sus scrofa)

l(3)mbt [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_115479.4, NP_056293.4

OpenTargets

ENSG00000185513

HPA

ENSG00000185513-L3MBTL1

ZINC - Substances

LMBL1_HUMAN

GeneCards

Q9Y468

ZINC target

Q9Y468

Ensembl

ENST00000427442, ENSG00000185513, ENSP00000362227, ENST00000373135, ENST00000422861, ENSP00000402107, ENSP00000410139

PRO

Q9Y468

Pharos - Targets

Q9Y468

ZINC - Predictions - Purchasable

LMBL1_HUMAN

PDB

2RJD, 3UWN, 2RJE, 2RI5, 2RHY, 2RHI, 1OYX, 2RHX, 3OQ5, 6BYB, 2RI2, 1OZ2, 2RJC, 2RHU, 2RI3, 2RJF, 2PQW, 3P8H, 2RHZ, 1OZ3

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.667	4
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.591	7
IntAct:EBI-15671479 H4K20			0.558	2
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.558	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	2
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.527	2
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.499	2
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.499	2

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