L3MBTL1 binds TP53 monomethylated on K382

Stable Identifier
R-HSA-3222116
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).

Literature References
PubMed ID Title Journal Year
20870725 The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression

West, LE, Roy, S, Lachmi-Weiner, K, Hayashi, R, Shi, X, Appella, E, Kutateladze, TG, Gozani, O

J. Biol. Chem. 2010
Participants
Participant Of
Orthologous Events
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