L3MBTL1 binds TP53 monomethylated on K382

Stable Identifier
R-HSA-3222116
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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L3MBTL1 binds TP53 monomethylated on K382
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The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).

Literature References
PubMed ID Title Journal Year
20870725 The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression

Hayashi, R, Kutateladze, TG, Roy, S, Appella, E, Lachmi-Weiner, K, Gozani, O, Shi, X, West, LE

J. Biol. Chem. 2010
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Orthologous Events
L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)
L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)
L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)
L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)
L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)
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