The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).
West, LE, Roy, S, Lachmi-Weiner, K, Hayashi, R, Shi, X, Appella, E, Kutateladze, TG, Gozani, O
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