L3MBTL1 binds TP53 monomethylated on K382

Stable Identifier
R-HSA-3222116
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).

Literature References
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Orthologous Events
L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)
L3MBTL1 binds TP53 monomethylated on K382 (Danio rerio)
L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)
L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)
L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)
L3MBTL1 binds TP53 monomethylated on K382 (Xenopus tropicalis)