Reactome | Me-K382,p-S15,S20-TP53 [nucleoplasm]

NP_001263690.1, NP_001263626.1, NP_001119584.1, NP_001119587.1, NP_001263689.1, NP_001263624.1, NP_001119585.1, NP_001119588.1, NP_001263627.1, NP_000537.3, NP_001263625.1, NP_001119586.1, NP_001119589.1, NP_001263628.1, NP_001119590.1

OpenTargets

ENSG00000141510

GeneCards

P04637

HPA

ENSG00000141510-TP53

ZINC - Substances

P53_HUMAN

ZINC target

P04637

Ensembl

ENSG00000141510, ENSP00000482537, ENST00000504290, ENST00000269305, ENSP00000478499, ENST00000622645, ENSP00000269305, ENST00000420246, ENSP00000391127, ENSP00000478219, ENST00000445888, ENST00000610292, ENST00000620739, ENSP00000398846, ENSP00000484409, ENST00000619485, ENST00000610538, ENST00000510385, ENSP00000391478, ENST00000455263, ENST00000504937, ENSP00000481179, ENSP00000482222, ENSP00000480868, ENSP00000481638

PRO

P04637

Pharos - Targets

P04637

Orphanet

15644

ZINC - Predictions - Purchasable

P53_HUMAN

PDB

5O1C, 5LAP, 1YCQ, 6RM5, 8DC6, 5HPD, 5O1D, 2AC0, 6RL3, 5MF7, 1YCR, 1TSR, 2F1X, 5AOM, 7B4C, 6VR5, 2YBG, 2J1Y, 2H59, 2J20, 2WGX, 2ATA, 6SHZ, 4IBS, 3IGK, 2H1L, 6GGE, 6RWS, 4IBQ, 7B4F, 3DAB, 4X34, 4KVP, 3LW1, 5MCV, 6SIP, 7DHZ, 3D07, 2FOJ, 7B46, 6RKK, 1SAK, 2OCJ, 6RZ3, 5MCW, 2GS0, 2VUK, 2X0V, 1SAL, 1YCS, 4IBT, 1DT7, 1KZY, 2X0W, 2MWO, 4QO1, 7NMI, 6SI2, 2FOO, 2MEJ, 2J21, 6GGC, 1UOL, 3D08, 2J1Z, 5O1B, 3DAC, 1MA3, 7XZX, 1OLH, 4HFZ, 2H4H, 4RP6, 2BIP, 1SAF, 6VRM, 5O1H, 6SI0, 6RL4, 2BIN, 3D0A, 7B49, 3PDH, 6RWH, 2J1X, 7B4D, 1YC5, 7EAX, 5HP0, 6SIN, 4IBZ, 7B4N, 5AOL, 4IBY, 2BIQ, 2H4J, 4XR8, 3Q06, 6S3C, 6RKM, 6SIQ, 5MHC, 5O1G, 4LOF, 1HS5, 6XRE, 1H26, 7V97, 5A7B, 2BIM, 2J11, 6VQO, 5AOJ, 6ZNC, 3OQ5, 6GGA, 3Q01, 6RK8, 5O1A, 7YGI, 1PES, 6LHD, 1GZH, 7RM4, 1OLG, 8A92, 5HOU, 7XZZ, 6V4F, 5MOC, 1PET, 4RP7, 2PCX, 4AGQ, 5AOK, 2L14, 1JSP, 2BIO, 6RWU, 5XZC, 7B47, 3Q05, 4AGO, 4IBV, 8A32, 7B4A, 2YDR, 4ZZJ, 1TUP, 7BWN, 2J0Z, 2XWR, 4AGM, 2H4F, 5BUA, 8F2H, 1XQH, 6SIO, 2X0U, 6RKI, 5UN8, 4IJT, 1SAE, 6S40, 4IBW, 2J1W, 7B4G, 7EDS, 3SAK, 4AGP, 5MG7, 6GGF, 6SL6, 4HJE, 4AGN, 2Z5T, 3TG5, 6RM7, 3IGL, 2LY4, 8DC7, 2H2F, 6FF9, 3KZ8, 2K8F, 2RUK, 5G4N, 4MZI, 2Z5S, 5O1I, 5OL0, 1A1U, 5O1F, 4BUZ, 6SI3, 1C26, 6S9Q, 2ADY, 4MZR, 2MZD, 6RX2, 4IBU, 8DC4, 7B48, 5ABA, 7DVD, 2AHI, 5LGY, 6VRN, 5O1E, 7DHY, 8F2I, 6FJ5, 6RL6, 5MCT, 7EEU, 2J10, 3KMD, 6SLV, 6RWI, 7B4E, 5G4M, 1AIE, 6GGD, 3ZME, 5ECG, 4BV2, 6W51, 8A31, 3D05, 6T58, 6V4H, 7B4H, 4LOE, 6RJZ, 3D06, 5G4O, 2H2D, 6S39, 3TS8, 2MWY, 8DC8, 2B3G, 6SI1, 2FEJ, 4AGL, 7B4B, 7EL4, 4LO9, 5AOI, 6GGB, 5MCU, 2MWP, 5AB9, 6VR1, 3D09, 6R5L, 6SI4

Interactors (225)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.995	110
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.98	33
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.976	22
IntAct:EBI-4399559 UBIQ			0.973	21
UniProt:P03070 LT			0.97	25
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.969	23
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.964	19
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.96	15
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.96	17
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.957	18
IntAct:EBI-1550784 CDKN1A			0.929	22
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.922	11
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.903	9
UniProt:Q96PM5 RCHY1	2	RCHY1 [cytosol] (R-HSA-976013) RCHY1 [nucleoplasm] (R-HSA-5655134)	0.892	13
UniProt:Q07817-1 BCL2L1			0.881	26
UniProt:Q12888-1 TP53BP1			0.879	17
UniProt:Q8IWT3 CUL9	2	G76-NEDD8-K1881-CUL9 [cytosol] (R-HSA-8955921) CUL9 [cytosol] (R-HSA-8855018)	0.85	7
UniProt:P26447 S10A4			0.848	9
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.846	14
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.845	10
UniProt:P06463 VE6			0.84	5
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.84	12
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.832	8
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.829	6
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.817	10
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.815	12
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.811	6
UniProt:P03126 VE6			0.807	5
UniProt:Q9NRG4 SMYD2	1	SMYD2 [nucleoplasm] (R-HSA-3222233)	0.806	6
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.778	6
UniProt:Q05086 UBE3A	1	UBE3A [cytosol] (R-HSA-976028)	0.77	6
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.766	4
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.761	11
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.751	13
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.75	5
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221)	0.74	9
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.737	6
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.737	5
UniProt:P43356 MAGA2			0.729	7
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.729	9
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.728	11
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.722	3
UniProt:P32776	1	TFB1 [nucleoplasm] (R-SCE-65912)	0.719	7
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.719	12
UniProt:Q8NHY2 COP1	3	p-S387-RFWD2 [cytosol] (R-HSA-349439) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [nucleoplasm] (R-HSA-349450)	0.717	5
UniProt:Q96KB5 TOPK			0.715	7
UniProt:P13693 TCTP			0.715	7
UniProt:Q16666-2 IFI16			0.715	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.713	7
UniProt:Q9H2X6 HIPK2	3	HIPK2 [nucleoplasm] (R-HSA-3215222) p-HIPK2 [nucleoplasm] (R-HSA-6799375) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.713	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.71	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.709	19
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.7	4
UniProt:Q9BUJ2 HNRNPUL1	1	HNRNPUL1 [nucleoplasm] (R-HSA-72106)	0.697	12
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.691	5
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.69	5
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.69	5
UniProt:P02829	11	HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.678	8
UniProt:Q9NRR4 DROSHA	1	DROSHA [nucleoplasm] (R-HSA-1482510)	0.677	5
UniProt:P06703 S10A6			0.676	3
UniProt:P29034 S10A2			0.676	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.676	6
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.674	7
UniProt:Q96M61 MAGBI			0.668	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.667	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.666	4
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.665	3
UniProt:O60341-1 KDM1A			0.664	6
UniProt:P26663-PRO_0000037536			0.664	9
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.659	3
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.658	3
UniProt:P03120 VE2			0.658	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.656	6
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.655	7
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.65	4
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.65	7
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.647	5
UniProt:O96017 CHEK2	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.646	3
UniProt:Q9BV47 DUS26			0.645	9
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.645	7
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.645	4
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.645	5
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.644	5
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.643	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	5
IntAct:EBI-1550787 MDM2			0.643	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.643	4
UniProt:Q9UPR3 SMG5	1	SMG5 [cytosol] (R-HSA-927867)	0.643	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.643	7
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.639	7
UniProt:P30405 PPIF			0.639	4
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.632	8
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.632	5
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.632	8
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.628	3
UniProt:P04019 VE6			0.623	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.623	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.623	4
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.623	3
UniProt:Q6PCD5 RFWD3			0.623	5
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.623	3
UniProt:P35232 PHB1	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.619	6
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.619	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.61	5
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.609	2
UniProt:Q9BWC9 CC106			0.608	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.602	4
UniProt:P89055 P89055			0.602	6
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.602	8
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.602	4
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) PRKCD [cytosol] (R-HSA-58200)	0.602	4
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.597	7
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.593	6
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.591	3
UniProt:Q06945 SOX4	1	SOX4 [nucleoplasm] (R-HSA-5625832)	0.591	4
UniProt:Q9UBF1 MAGC2			0.591	3
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.591	5
UniProt:Q8TAQ5 ZNF420	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.591	4
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.59	4
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.589	2
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.589	5
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.589	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.589	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.589	6
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.581	6
UniProt:Q96GM8 TOE1			0.577	3
UniProt:P61289 PSME3	2	PSME3 [nucleoplasm] (R-HSA-174310) PSME3 [cytosol] (R-HSA-68816)	0.576	7
UniProt:O43847 NRDC			0.576	6
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.571	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.571	2
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.564	2
UniProt:P25208 NFYB	1	NFYB [nucleoplasm] (R-HSA-381067)	0.564	6
UniProt:P06748-1 NPM1			0.564	3
UniProt:Q9H7Z6 KAT8	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.564