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NOC2L [nucleoplasm]
Stable Identifier
R-HSA-3222129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nucleolar complex protein 2 homolog, Novel INHAT repressor, NIR
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
AURKB binds TP53 (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
AURKB phosphorylates TP53 (Homo sapiens)
AURKB:NOC2L:p-S15,S20,S269,T284-TP53 [nucleoplasm] (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
NOC2L binds TP53 (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
NOC2L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3T9 NOC2L
Gene Names
NOC2L, NIR
Chain
chain:1-749
Reference Genes
BioGPS Gene:26155 NOC2L
COSMIC (genes):NOC2L NOC2L
CTD Gene:26155 NOC2L
dbSNP Gene:26155 NOC2L
ENSEMBL:ENSG00000188976 NOC2L
ENSEMBL_homo_sapiens_GENE:ENSG00000188976.11 NOC2L
HGNC:24517 NOC2L
KEGG Gene (Homo sapiens):26155 NOC2L
Monarch:26155 NOC2L
NCBI Gene:26155 NOC2L
OMIM:610770 NOC2L
UCSC:Q9Y3T9 NOC2L
Reference Transcript
RefSeq:NM_015658.3 NOC2L
Other Identifiers
11746519_x_at
11757561_s_at
202115_PM_s_at
202115_s_at
2505421
2505422
2505426
2505427
2505430
2505432
2505433
2505434
2505437
2505438
2505439
2505441
2505442
2576530
2576532
2576533
2576534
2576536
2576538
2576542
2576544
26155
4054638
4054640
4054641
4054642
4054643
4054645
4054647
4054648
4054649
4054652
4054653
4054658
4054659
4054660
4054661
4054663
4054664
4054667
4054668
4054669
4054670
4054672
4054673
4054674
41861_at
63975_s_at
7911359
A_23_P138058
GE56228
GO:0000122
GO:0002903
GO:0003682
GO:0003714
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006915
GO:0012501
GO:0023052
GO:0030690
GO:0030691
GO:0031491
GO:0034644
GO:0042254
GO:0042273
GO:0042393
GO:0043226
GO:0045815
GO:0140110
GO:0140297
GO:2001243
HMNXSV003036570
ILMN_1792820
TC01002078.hg
g7661605_3p_a_at
Participates
as a component of
AURKB:NOC2L:p-S15,S20,S269,T284-TP53 [nucleoplasm] (Homo sapiens)
NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
as an input of
NOC2L binds TP53 (Homo sapiens)
Inferred To
Noc2 [nucleoplasm]
(Drosophila melanogaster)
Noc2l [nucleoplasm]
(Mus musculus)
Noc2l [nucleoplasm]
(Rattus norvegicus)
noc2l [nucleoplasm]
(Xenopus tropicalis)
NOC2L [nucleoplasm]
(Bos taurus)
NOC2L [nucleoplasm]
(Canis familiaris)
NOC2L [nucleoplasm]
(Dictyostelium discoideum)
NOC2L [nucleoplasm]
(Gallus gallus)
NOC2L [nucleoplasm]
(Plasmodium falciparum)
NOC2L [nucleoplasm]
(Schizosaccharomyces pombe)
NOC2L [nucleoplasm]
(Sus scrofa)
NOC2 [nucleoplasm]
(Saccharomyces cerevisiae)
pro-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_056473.2
OpenTargets
ENSG00000188976
GeneCards
Q9Y3T9
HPA
ENSG00000188976-NOC2L
Ensembl
ENST00000327044
,
ENSP00000317992
,
ENSG00000188976
PRO
Q9Y3T9
Pharos - Targets
Q9Y3T9
PDB
8FKV
,
8FKY
,
8FKX
,
8FKW
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.632
8
UniProt:P11487 FGF3
1
FGF3 [extracellular region]
(R-HSA-189886)
0.527
2
UniProt:P42696 RBM34
0.527
2
UniProt:P51608 MECP2
0.527
3
UniProt:Q02543 RPL18A
1
RPL18A [cytosol]
(R-HSA-72422)
0.527
2
UniProt:Q9NY72 SCN3B
1
SCN3B [plasma membrane]
(R-HSA-197921)
0.527
2
UniProt:Q9BXY0 MAK16
0.527
3
UniProt:Q53GL0 PKHO1
0.527
2
UniProt:Q96FN4 CPNE2
0.527
2
UniProt:Q96LZ2 MAGBA
0.527
2
UniProt:Q07020 RPL18
1
RPL18 [cytosol]
(R-HSA-72420)
0.527
3
UniProt:Q96ME7 ZN512
0.527
2
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.527
2
UniProt:P01127 PDGFB
8
PDGFB (82-190) [extracellular region]
(R-HSA-184201)
PDGFB(82-241) [extracellular region]
(R-HSA-381904)
PDGFB(1-241) [endoplasmic reticulum lumen]
(R-HSA-381903)
PDGFB(1-241) [Golgi membrane]
(R-HSA-380740)
PDGFB(1-81) [Golgi lumen]
(R-HSA-389058)
PDGFB(191-241) [Golgi lumen]
(R-HSA-396945)
PDGFB(21-81) [platelet alpha granule lumen]
(R-HSA-184200)
PDGFB(82-241) [platelet alpha granule lumen]
(R-HSA-387075)
0.527
2
UniProt:P62263 RPS14
2
RPS14 [nucleoplasm]
(R-HSA-6790669)
RPS14 [cytosol]
(R-HSA-72333)
0.527
2
UniProt:O43159 RRP8
1
RRP8 [nucleoplasm]
(R-HSA-427524)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [cytosol]
(R-HSA-201591)
ATXN7 [nucleoplasm]
(R-HSA-8869458)
0.508
2
UniProt:Q8WYQ5 DGCR8
1
DGCR8 [nucleoplasm]
(R-HSA-1482509)
0.483
2
UniProt:P62753 RPS6
4
RPS6 [nucleoplasm]
(R-HSA-6790606)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
RPS6 [cytosol]
(R-HSA-72381)
0.483
2
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