Reactome | SMYD2 [nucleoplasm]

SMYD2 [nucleoplasm]

Stable Identifier

R-HSA-3222233

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2, KMT3C

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SMYD2 methylates TP53 (Homo sapiens)
        
        SMYD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRG4 SMYD2

Gene Names

SMYD2, KMT3C

Chain

chain:1-433

Reference Genes

BioGPS Gene:56950 SMYD2

COSMIC (genes):SMYD2 SMYD2

CTD Gene:56950 SMYD2

dbSNP Gene:56950 SMYD2

ENSEMBL:ENSG00000143499 SMYD2

HGNC:20982 SMYD2

KEGG:hsa:56950 SMYD2

Monarch:56950 SMYD2

NCBI Gene:56950 SMYD2

OMIM:610663 SMYD2

UCSC:Q9NRG4 SMYD2

Reference Transcript

Other Identifiers

11754789_a_at

16677407

212922_PM_s_at

212922_s_at

2379761

2379762

2379763

2379764

2379778

2379779

2379780

2379781

2379787

2379790

2379791

2379792

2379793

2379794

2379795

2379796

2379797

2379798

2379799

2379800

2379804

2379805

2379806

243288_PM_at

243288_at

56950

69860_r_at

7909689

A_14_P108715

A_14_P126738

A_23_P170587

GE501333

GE79557

GO:0000122

GO:0000993

GO:0002039

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006355

GO:0007507

GO:0008168

GO:0008270

GO:0008285

GO:0016278

GO:0016279

GO:0016740

GO:0018026

GO:0018027

GO:0032259

GO:0042054

GO:0043516

GO:0046872

GO:0046975

GO:0048856

GO:0140096

GO:0140938

GO:0140999

GO:1901796

HMNXSV003038187

Hs.201767.0.A1_3p_at

Hs.66170.1.A1_3p_a_at

ILMN_1721605

PH_hs_0004043

TC01001790.hg

Participates

as a member of

WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)

Inferred To

Smyd2 [nucleoplasm] (Mus musculus)

Smyd2 [nucleoplasm] (Rattus norvegicus)

set-30 [nucleoplasm] (Caenorhabditis elegans)

set-14 [nucleoplasm] (Caenorhabditis elegans)

smyd2a [nucleoplasm] (Danio rerio)

set-18 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SMYD2 [nucleoplasm] (Caenorhabditis elegans)

Smyd3 [nucleoplasm] (Drosophila melanogaster)

set-10 [nucleoplasm] (Caenorhabditis elegans)

SMYD2 [nucleoplasm] (Bos taurus)

SMYD2 [nucleoplasm] (Canis familiaris)

SMYD2 [nucleoplasm] (Plasmodium falciparum)

SMYD2 [nucleoplasm] (Sus scrofa)

smyd2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_047281658.1, NP_064582.2

ZINC - World Drugs

SMYD2_HUMAN

Guide to Pharmacology - Targets

2714

OpenTargets

ENSG00000143499

ENSEMBL

ENST00000366957, ENSG00000143499, ENSP00000355924

ZINC - Substances

SMYD2_HUMAN

ZINC - Biogenic

SMYD2_HUMAN

ZINC target

Q9NRG4

PRO

Q9NRG4

GlyGen

Q9NRG4

PDB

4YND, 3TG4, 6N3G, 4WUY, 9CKC, 3RIB, 9CKG, 9CKF, 5KJM, 5KJL, 3S7F, 3TG5, 3S7D, 3S7J, 5WCG, 4O6F, 5KJN, 6MON, 5KJK, 5V3H, 6CBY, 3S7B, 6CBX, 5ARG, 5ARF

ZINC - Metabolites

SMYD2_HUMAN

IntEnz

2.1.1.354

HPA

ENSG00000143499-SMYD2

GeneCards

SMYD2

Pharos - Targets

Q9NRG4

ZINC - Predictions - Purchasable

SMYD2_HUMAN

HMDB Protein

HMDBP11961

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.806	6
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.669	3
UniProt:Q9UPZ9 CILK1			0.657	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	2
UniProt:Q96K17 BT3L4			0.556	3
UniProt:Q9Y5W9 SNX11			0.556	3
UniProt:P20290-2 BTF3			0.556	3
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.527	2
UniProt:P01160 NPPA	5	NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:Q9UNI1 CELA1			0.527	2
UniProt:O60293 ZFC3H1	1	ZFC3H1 [nucleoplasm] (R-HSA-9930046)	0.527	2

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