Reactome: A Curated Pathway Database

SMYD2 methylates TP53

Stable Identifier
R-HSA-3222237
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
lysine N-methyltransferase activity of SMYD2 [nucleoplasm] SMYD2 [nucleoplasm] lysine N-methyltransferase activity (0016278)
Orthologous Events