PHF20 binds TP53 dimethylated on K370 and K382

Stable Identifier
R-HSA-3222259
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PHF20 binds TP53 (p53) dimethylated at lysine residues K370 and K382 by unidentified protein lysine methyltransferase(s). PHF20 binding interferes with MDM2 binding to TP53, thus resulting in TP53 stabilization (Cui et al. 2012).

Literature References
PubMed ID Title Journal Year
22864287 PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 Nat. Struct. Mol. Biol. 2012
Participants
Participant Of
Orthologous Events