Expression of MINK1/TNIK is positively regulated by ROS

Stable Identifier
R-HSA-3225867
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Expression of MINK1/TNIK is positively regulated by ROS
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Reactive oxygen species (ROS) generated as a consequence of oncogenic RAS signaling induce expression and activation of Ste20 family kinases MINK1 (MINK), TNIK and, possibly, MAP4K4, which contributes to growth arrest and cellular senescence (Nicke et al. 2005).
Literature References
PubMed ID Title Journal Year
16337592 Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

Peters, G, Cowling, V, Nicke, B, Downward, J, Berns, K, Bernards, R, Cook, SJ, Khanna, SJ, Delpuech, O, Hancock, DC, Beijersbergen, RL, Warne, PH, Schulze, A, Ganesan, TS, Bastien, J, Mullenders, J

Mol. Cell 2005
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
ROS [cytosol]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-25)
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